公开(公告)号：US20060084169A1

公开(公告)日：2006-04-20

申请号：US11244890

申请日：2005-10-06

申请人： Gregor Boese ,  Wolfgang Albrecht ,  Guenther Malsch ,  Thomas Groth ,  Andreas Lendlein ,  Hans-Jurgen Stark ,  Norbert Fusenig

发明人： Gregor Boese ,  Wolfgang Albrecht ,  Guenther Malsch ,  Thomas Groth ,  Andreas Lendlein ,  Hans-Jurgen Stark ,  Norbert Fusenig

IPC分类号： C12N5/08

CPC分类号： B01D71/64 ,  B01D71/42 ,  C12N5/0068 ,  C12N2533/30

摘要： The invention relates to a polymer substrate for cultivating tissue cells. The substrate is provided in form of an oxygen-permeable flat membrane, preferably with ultra-filtration properties, and has an optimized amine content of at least 10 nmole amine function per cm2 membrane. The substrate can be used to treat burns and other tissue defects. The substrate can be rapidly populated with cells, in particular with keratinozytes, and supports reorientation of the cells after the populated membrane is transferred to a wound or a dermis equivalent. The substrate can also be later easily detached from the newly formed tissue structure.

摘要翻译： 本发明涉及一种培养组织细胞的聚合物底物。 基底以透氧的平膜的形式提供，优选具有超滤性质，并且具有每厘米膜至少10nmole胺功能的优化的胺含量。 该基质可用于治疗烧伤和其他组织缺陷。 底物可以用细胞，特别是用角蛋白酶快速填充，并且在将填充的膜转移到伤口或真皮等价物之后支持细胞的重新定向。 基底也可以随后从新形成的组织结构中容易地分离。

公开(公告)号：US20070093562A1

公开(公告)日：2007-04-26

申请号：US11566388

申请日：2006-12-04

申请人： Thomas Groth ,  Wolfgang Albrecht ,  Barbara Seifert ,  Gunter Malsch ,  James Courtney ,  John David Gaylor ,  Mary Grant

发明人： Thomas Groth ,  Wolfgang Albrecht ,  Barbara Seifert ,  Gunter Malsch ,  James Courtney ,  John David Gaylor ,  Mary Grant

IPC分类号： C08J5/20

CPC分类号： B01D71/76 ,  A61M1/3489 ,  B01D71/40 ,  B01D71/42 ,  C08F220/44 ,  C08L33/14 ,  C08L33/20

摘要： Polymeric composition, material produced thereof and their applications The invention relates to a novel polymer composition comprising at least one copolymer constituted of acrylic (AC) monomer units and of at least one water-soluble comonomer unit, which is preferably 2-acrylamido-2-methyl-propane sulfonic acid (AMPS). The composition is used to produce materials, such as membranes, film or suface coatings, that are suitable as highly tissue compatible supports for epithelial cells, such as hepatocytes. The materials are suitable to be used in a bioartificial liver, where they work as separating membrane and carrier for adhesion-dependent tissue cells. As an example it is described how selectively permeable membranes are formed by a phase inversion process from these acrylic copolymers with varying content of 2-acrylamido-2-methyl-propane sulfonic acid (AMPS) and how they interact with liver cells to construct a biohybrid organ for liver replacement.

摘要翻译： 聚合物组合物及其应用本发明涉及包含至少一种由丙烯酸（AC）单体单元和至少一种水溶性共聚单体单元构成的共聚物的新型聚合物组合物，其优选为2-丙烯酰胺基-2- 甲基丙烷磺酸（AMPS）。 该组合物用于生产诸如膜，膜或表面涂层的材料，其适合作为上皮细胞如肝细胞的高度组织相容的载体。 该材料适用于生物人造肝脏，其中它们作为分离膜和载体用于粘附依赖性组织细胞。 作为示例，描述了如何通过具有不同含量的2-丙烯酰氨基-2-甲基 - 丙磺酸（AMPS）的这些丙烯酸共聚物的相转化方法形成选择性渗透膜以及它们如何与肝细胞相互作用以构建生物混合物 肝脏置换器官

公开(公告)号：US20060058479A1

公开(公告)日：2006-03-16

申请号：US10527227

申请日：2003-09-05

申请人： Thomas Groth ,  Wolfgang Albrecht ,  Barbara Seifert ,  Guenter Malsch ,  James McNiven Courtney ,  John Gaylor ,  Mary Grant

发明人： Thomas Groth ,  Wolfgang Albrecht ,  Barbara Seifert ,  Guenter Malsch ,  James McNiven Courtney ,  John Gaylor ,  Mary Grant

IPC分类号： C08F2/00 ,  C08F4/00

CPC分类号： B01D71/76 ,  A61M1/3489 ,  B01D71/40 ,  B01D71/42 ,  C08F220/44 ,  C08L33/14 ,  C08L33/20

摘要： The invention relates to a novel polymer composition comprising at least one copolymer constituted of acrylic (AC) monomer units and of at least one water-soluble comonomer unit, which is preferably 2-acrylamido-2-methyl-propane sulfonic acid (AMPS). The composition is used to produce materials, such as membranes, film or suface coatings, that arc suitable as highly tissue compatible supports for epithelial cells, such as hepatocytes. The materials are suitable to be used in a bioartificial liver, where they work as separating membrane and carrier for adhesion-dependent tissue cells. As an example it is described how selectively permeable membranes are formed by a phase inversion process from these acrylic copolymers with varying content of 2-aclylanido-2-methylpropane sulfonic acid (AMPS) and how they interact with liver cells to construct a biohybrid organ for liver replacement.

摘要翻译： 本发明涉及包含至少一种由丙烯酸（AC）单体单元和至少一种水溶性共聚单体单元构成的共聚物的新型聚合物组合物，其优选为2-丙烯酰胺基-2-甲基 - 丙磺酸（AMPS）。 该组合物用于生产诸如膜，膜或表面涂层的材料，其适合作为上皮细胞如肝细胞的高度组织相容的载体。 该材料适用于生物人造肝脏，其中它们作为分离膜和载体用于粘附依赖性组织细胞。 作为示例，描述了通过具有不同含量的2-丙烯酰氨基-2-甲基丙磺酸（AMPS）的这些丙烯酸共聚物的相转化方法形成选择性渗透膜的方式，以及它们如何与肝细胞相互作用以构建生物混合器官 肝脏替代

公开(公告)号：US07485249B2

公开(公告)日：2009-02-03

申请号：US10762225

申请日：2004-01-16

申请人： Wolfgang Albrecht ,  Dieter Paul ,  Roland Hilke ,  Barbara Seifert ,  Thomas Weigel ,  Thomas Groth

发明人： Wolfgang Albrecht ,  Dieter Paul ,  Roland Hilke ,  Barbara Seifert ,  Thomas Weigel ,  Thomas Groth

IPC分类号： B01D69/12

CPC分类号： D01F8/08 ,  A61M1/3489 ,  B01D69/02 ,  B01D69/08 ,  B01D69/12 ,  B01D71/42 ,  D01D5/24

摘要： In a method of manufacturing a double-layer membrane of different polymers or polymer mixtures with opposite blood-compatible and tissue-compatible surfaces, a first polymer solution of a blood-compatible polymer and a second solution of a tissue-compatible polymer are extruded concurrently in layered form through a nozzle into a coagulation bath so as to form a double layer membrane.

摘要翻译： 在制备具有相反血液相容性和组织相容性表面的不同聚合物或聚合物混合物的双层膜的方法中，血液相容性聚合物的第一聚合物溶液和组织相容性聚合物的第二溶液同时挤出 以分层形式通过喷嘴进入凝固浴，以形成双层膜。

公开(公告)号：US09012464B2

公开(公告)日：2015-04-21

申请号：US13989603

申请日：2011-11-23

申请人： Ramesh Matioram Gidwani ,  Channaveerayya Hiremath ,  Manoj Dalsingar Yadav ,  Wolfgang Albrecht ,  Dirk Fischer

发明人： Ramesh Matioram Gidwani ,  Channaveerayya Hiremath ,  Manoj Dalsingar Yadav ,  Wolfgang Albrecht ,  Dirk Fischer

IPC分类号： C07D405/12

CPC分类号： C07D405/12

摘要： Afatinib salts and crystalline forms thereof are described in the present application and processes for their preparation. Crystalline forms of Afatinib are also described in the present application and processes for their preparation. The present invention also includes pharmaceutical compositions of such Afatinib salts and crystalline forms thereof or crystalline forms of Afatinib, methods of their preparation and the use thereof in the treatment of a patient in need thereof.

摘要翻译： 在本申请中描述了阿片碱及其结晶形式及其制备方法。 在本申请中还描述了阿片碱的结晶形式及其制备方法。 本发明还包括这样的阿拉非尼碱盐及其结晶形式或结晶形式的阿拉金滨的药物组合物，其制备方法及其在治疗有需要的患者中的用途。

公开(公告)号：US08947188B2

公开(公告)日：2015-02-03

申请号：US14000435

申请日：2012-03-02

申请人： Christian Hammer ,  Wolfgang Albrecht ,  Christian Pircher ,  Sebastian Rehkopf ,  Andreas Sachsenhauser ,  Konrad Raedlinger ,  Andreas Stelzer ,  Joerg Teichmann ,  Andreas Lawall ,  Sylvio Kosse ,  Werner Hartmann ,  Norbert Wenzel ,  Astrid Renz

发明人： Christian Hammer ,  Wolfgang Albrecht ,  Christian Pircher ,  Sebastian Rehkopf ,  Andreas Sachsenhauser ,  Konrad Raedlinger ,  Andreas Stelzer ,  Joerg Teichmann ,  Andreas Lawall ,  Roman Renz ,  Sylvio Kosse ,  Werner Hartmann ,  Norbert Wenzel

IPC分类号： H01H21/12 ,  H01H33/66 ,  G05F1/14 ,  H01F29/04 ,  H01H9/00 ,  H01H33/664 ,  H01H33/16 ,  H01H33/666

CPC分类号： H01F29/04 ,  H01H9/0038 ,  H01H33/16 ,  H01H33/6647 ,  H01H2033/6668

摘要： The invention relates to a tap changer for the interruption-free switchover between winding taps of a tap-changing transformer. Furthermore, the present invention relates to a novel vacuum interrupter which is particularly suitable for such a tap changer. The tap changer according to the invention is based on the general concept of combining in each case one main contact (V1) and one mechanical switching means (U1), connected in series therewith, of a first load branch and an additional resistive contact (V3) of a second load branch in only a single vacuum interrupter (1) with a common housing (5). The vacuum interrupter (1) according to the invention is furthermore based on the general inventive concept of replacing the functionalities of two required vacuum interrupters in accordance with the prior art and an additional mechanical switching means with a single vacuum interrupter (1) according to the invention by virtue of combining the design of a vacuum interrupter (1) with a plurality of moveable contact systems (I, II, III), which are arranged in separate vacuum interrupter chambers (2, 3, 4) which are sealed with respect to one another.

摘要翻译： 本发明涉及一种用于分接变换变压器的绕组抽头之间无中断切换的抽头变换器。 此外，本发明涉及一种特别适用于这种分接开关的新型真空断路器。 根据本发明的分接开关基于在每种情况下组合一个主触头（V1）和一个与其串联连接的一个机械开关装置（U1）的一般概念，第一负载支路和附加电阻触点（V3 ）仅在具有公共壳体（5）的单个真空断续器（1）中的第二负载分支。 此外，根据本发明的真空断续器（1）还基于根据现有技术替换两个所需真空断路器的功能的总体发明构思，以及根据本发明的具有单个真空断路器（1）的附加机械开关装置 通过将真空断路器（1）的设计与多个可移动接触系统（I，II，III）组合的发明，其布置在分开的真空断路器室（2,3,4）中，所述真空断路器相对于 另一个。

公开(公告)号：US08633312B2

公开(公告)日：2014-01-21

申请号：US13122883

申请日：2009-10-09

申请人： Stefan Laufer ,  Wolfgang Albrecht

发明人： Stefan Laufer ,  Wolfgang Albrecht

IPC分类号： C07D295/03 ,  A61K31/5375

CPC分类号： C07D295/088 ,  C07C49/747 ,  C07C49/755 ,  C07C205/45 ,  C07C205/58 ,  C07C205/59 ,  C07C225/22 ,  C07C229/12 ,  C07C229/34 ,  C07C271/54 ,  C07C309/65 ,  C07C2603/32 ,  C07D309/12 ,  C07D313/12 ,  C07D317/22 ,  C07D405/04

摘要： The present invention relates to compounds of the formula I wherein R1, R2, R3, R4, X and Y have the meanings given in the description. The compounds have an action which is immunomodulating and inhibits or regulates the release of IL-1β and/or TNF-α. They can therefore be used for treatment of diseases connected with a disturbance in the immune system.

摘要翻译： 本发明涉及式Ⅰ化合物，其中R1，R2，R3，R4，X和Y具有说明书中给出的含义。 该化合物具有免疫调节作用，并且抑制或调节IL-1β和/或TNF-α的释放。 因此，它们可用于治疗与免疫系统紊乱相关的疾病。

公开(公告)号：US08519155B2

公开(公告)日：2013-08-27

申请号：US13126216

申请日：2009-10-30

申请人： Wolfgang Albrecht ,  Hans-Günter Striegel ,  Stefan Laufer

发明人： Wolfgang Albrecht ,  Hans-Günter Striegel ,  Stefan Laufer

IPC分类号： C07D487/06 ,  A61K31/403

CPC分类号： C07D487/04

摘要： The present invention relates to the choline and tromethamine salt of Licofelone.

摘要翻译： 本发明涉及Licofelone的胆碱和氨基丁三醇盐。

公开(公告)号：US20110063064A1

公开(公告)日：2011-03-17

申请号：US12989668

申请日：2009-04-07

申请人： Wolfgang Albrecht ,  Dieter Dohnal ,  Rainer Frotscher ,  Klaus Schlepp

发明人： Wolfgang Albrecht ,  Dieter Dohnal ,  Rainer Frotscher ,  Klaus Schlepp

IPC分类号： H01F27/14 ,  H01F29/04

CPC分类号： H01F27/14 ,  H01F2027/404 ,  H01H9/0044

摘要： The abstract relates to an arrangement of an oil-filled power transformer having an oil-filled stepping switch, wherein only a single oil expansion vessel is provided, this oil expansion vessel being connected both to the oil volume of the stepping switch and also to the transformer tank, which is likewise oil-filled, via corresponding flanges.

摘要翻译： 本发明涉及具有充油步进开关的充油电力变压器的布置，其中仅设置单个油膨胀容器，该油膨胀容器连接到步进开关的油量，并且还连接到 变压器油箱，同样充满油，通过相应的法兰。

公开(公告)号：US4481442A

公开(公告)日：1984-11-06

申请号：US352720

申请日：1982-02-26

申请人： Wolfgang Albrecht ,  Dieter Hofmann ,  Lutz Klein ,  Ernst Panofski

发明人： Wolfgang Albrecht ,  Dieter Hofmann ,  Lutz Klein ,  Ernst Panofski

IPC分类号： H01J61/32 ,  C03B23/06 ,  C03B23/07 ,  H01J61/30 ,  H01J63/04 ,  H01J9/00

CPC分类号： C03B23/065 ,  C03B23/06 ,  C03B23/07 ,  H01J61/30

摘要： To reduce the operating temperature of a U-shaped or multiple U-bent fluocent lamp, the respective longitudinal and transverse sectional elements of the U-shaped lamp are so related that the outer generating line M.sub.Q of the individual transverse tube sections (4; 20, 21, 22) is substantially straight;the diameter D.sub.LQ in the tube bends (5, 6; 23, 24, 25, 26, 27, 28) at the transition between the longitudinal tube sections (2, 3; 16, 17, 18, 19) and the respective transverse tube sections (4; 20, 21, 22) is larger than the diameter D.sub.Q of the individual transverse tube sections in the middle thereof,and the diameter D.sub.Q of the transverse tube section is at least as large as the diameter D.sub.L of the longitudinal tube sections;a depression or dent can be formed at the center of the outer surface of the transverse tube section, and the corners of the transverse tube section can include additional heat dissipating material to further reduce the operating temperature.

摘要翻译： 为了降低U形或多个U形弯曲荧光灯的工作温度，U形灯的各个纵向和横向截面元件与各个横向管部分（4; 20）的外部发生线MQ相关 ，21,22）基本上是直的; 在纵管部分（2,3; 16,17,18,19）和相应的横管之间的过渡处，管中的直径DLQ弯曲（5,6; 23,24,25,26,27,28） 部分（4; 20,21,22）大于其中间的各个横管部分的直径DQ，并且横管部分的直径DQ至少与纵管部分的直径DL一样大 ; 可以在横管部分的外表面的中心处形成凹陷或凹陷，并且横管部分的角部可以包括另外的散热材料以进一步降低工作温度。