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    Visual indication of rupture of drug reservoir
    2.
    发明授权
    Visual indication of rupture of drug reservoir 失效
    药库破裂的视觉指示

    公开(公告)号：US08657804B2

    公开(公告)日：2014-02-25

    申请号：US12910572

    申请日：2010-10-22

    申请人： Kenneth N. Horne ,  Gregory J. R. Spooner ,  John A. Scholl ,  John T. Santini, Jr.

    发明人： Kenneth N. Horne ,  Gregory J. R. Spooner ,  John A. Scholl ,  John T. Santini, Jr.

    IPC分类号： A61M31/00

    CPC分类号： A61F9/0017 ,  A61F2002/30714 ,  A61F2250/0068 ,  A61F2250/0089 ,  A61F2250/0097 ,  A61K9/0009 ,  A61K9/0051

    摘要： The present disclosure relates to methods for visualizing the opening of a drug reservoir of an implantable medical device. In particular, the present disclosure provides methods for observing the release or exposure of contents from a drug reservoir of a medical device placed within the vitreous of an eye of a subject. The methods include implanting a drug delivery device within an anatomy of a subject. The drug device includes a plurality of reservoirs, each loaded with a therapeutic agent and a marker. Furthermore, the drug delivery device comprises a plurality of barrier layers for separating the contents of one of the plurality of reservoirs from the anatomy. The method further includes irradiating at least one of the plurality of barrier layers such that at least one of the plurality of reservoirs is breached, thereby triggering release of the therapeutic agent and the marker from the device. By visually detecting release of the marker into the anatomy, release of the therapeutic agent into the anatomy is verified.

    摘要翻译： 本公开涉及用于可视化可植入医疗装置的药物储存器的开口的方法。 特别地，本公开提供了观察从放置在受试者的眼睛的玻璃体内的医疗装置的药物储存器释放或暴露内容物的方法。 所述方法包括将药物递送装置植入受试者的解剖结构内。 药物装置包括多个储存器，每个储存器装载有治疗剂和标记物。 此外，药物递送装置包括用于将多个储存器中的一个的内容物与解剖结构分离的多个阻挡层。 该方法还包括照射多个阻挡层中的至少一个，使得多个储存器中的至少一个被破坏，从而触发治疗剂和标记物从装置释放。 通过目视检测将标记物释放到解剖结构中，验证了治疗剂释放到解剖结构中。

    Low-permeability, laser-activated drug delivery device
    4.
    发明授权
    Low-permeability, laser-activated drug delivery device 有权
    低渗透性，激光激活药物输送装置

    公开(公告)号：US08911426B2

    公开(公告)日：2014-12-16

    申请号：US13023370

    申请日：2011-02-08

    申请人： Jonathan Robert Coppeta ,  Kenneth N. Horne ,  John T. Santini, Jr. ,  John A. Scholl ,  Gregory J. R. Spooner ,  Cynthia L. Stevenson ,  Naveed Shams ,  Andrew Poutiatine

    发明人： Jonathan Robert Coppeta ,  Kenneth N. Horne ,  John T. Santini, Jr. ,  John A. Scholl ,  Gregory J. R. Spooner ,  Cynthia L. Stevenson ,  Naveed Shams ,  Andrew Poutiatine

    IPC分类号： A61K9/22 ,  A61K9/00 ,  A61F9/00 ,  A61F9/008

    CPC分类号： A61F9/0017 ,  A61F9/008 ,  A61K9/0009 ,  A61K9/0051

    摘要： An implantable drug delivery device that uses multiple reservoir elements to contain and release doses of active pharmaceutical ingredients. The device includes a first shell element, which has a first enclosed cavity volume and forms a low-permeability barrier. The first shell element is configured to absorb light irradiation from a laser source, the laser irradiation causing a breach in the first shell element. A first active pharmaceutical ingredient is contained in the first enclosed cavity volume and is released when the first shell element is breached. The device also includes a second shell element, which has a second enclosed cavity volume and also forms a low-permeability barrier. A second active pharmaceutical ingredient is contained in the second enclosed cavity volume. The device also includes an envelope element containing the first and second shell elements.

    摘要翻译： 一种可植入药物递送装置，其使用多个储存元件来容纳和释放剂量的活性药物成分。 该装置包括第一壳单元，其具有第一封闭空腔体积并形成低渗透屏障。 第一壳元件被配置为吸收来自激光源的光照射，激光照射引起第一壳元件中的破裂。 第一活性药物成分包含在第一封闭空腔体积中，并且当第一壳元件被破坏时被释放。 该装置还包括第二壳单元，其具有第二封闭空腔体积并且还形成低渗透屏障。 第二活性药物成分包含在第二封闭空腔体积中。 该装置还包括包含第一和第二壳单元的包络元件。