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公开(公告)号：US08911426B2
公开(公告)日：2014-12-16
申请号：US13023370
申请日：2011-02-08
申请人： Jonathan Robert Coppeta , Kenneth N. Horne , John T. Santini, Jr. , John A. Scholl , Gregory J. R. Spooner , Cynthia L. Stevenson , Naveed Shams , Andrew Poutiatine
发明人： Jonathan Robert Coppeta , Kenneth N. Horne , John T. Santini, Jr. , John A. Scholl , Gregory J. R. Spooner , Cynthia L. Stevenson , Naveed Shams , Andrew Poutiatine
CPC分类号： A61F9/0017 , A61F9/008 , A61K9/0009 , A61K9/0051
摘要： An implantable drug delivery device that uses multiple reservoir elements to contain and release doses of active pharmaceutical ingredients. The device includes a first shell element, which has a first enclosed cavity volume and forms a low-permeability barrier. The first shell element is configured to absorb light irradiation from a laser source, the laser irradiation causing a breach in the first shell element. A first active pharmaceutical ingredient is contained in the first enclosed cavity volume and is released when the first shell element is breached. The device also includes a second shell element, which has a second enclosed cavity volume and also forms a low-permeability barrier. A second active pharmaceutical ingredient is contained in the second enclosed cavity volume. The device also includes an envelope element containing the first and second shell elements.
摘要翻译： 一种可植入药物递送装置，其使用多个储存元件来容纳和释放剂量的活性药物成分。 该装置包括第一壳单元，其具有第一封闭空腔体积并形成低渗透屏障。 第一壳元件被配置为吸收来自激光源的光照射，激光照射引起第一壳元件中的破裂。 第一活性药物成分包含在第一封闭空腔体积中，并且当第一壳元件被破坏时被释放。 该装置还包括第二壳单元，其具有第二封闭空腔体积并且还形成低渗透屏障。 第二活性药物成分包含在第二封闭空腔体积中。 该装置还包括包含第一和第二壳单元的包络元件。
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公开(公告)号：US20120035528A1
公开(公告)日：2012-02-09
申请号：US13023370
申请日：2011-02-08
申请人： Jonathan R. Coppeta , Kenneth N. Horne , John T. Santini, JR. , John A. Scholl , Gregory J.R. Spooner , Cynthia L. Stevenson , Naveed Shams , Andrew Poutiatine
发明人： Jonathan R. Coppeta , Kenneth N. Horne , John T. Santini, JR. , John A. Scholl , Gregory J.R. Spooner , Cynthia L. Stevenson , Naveed Shams , Andrew Poutiatine
CPC分类号： A61F9/0017 , A61F9/008 , A61K9/0009 , A61K9/0051
摘要： An implantable drug delivery device that uses multiple reservoir elements to contain and release doses of active pharmaceutical ingredients. The device includes a first shell element, which has a first enclosed cavity volume and forms a low-permeability barrier. The first shell element is configured to absorb light irradiation from a laser source, the laser irradiation causing a breach in the first shell element. A first active pharmaceutical ingredient is contained in the first enclosed cavity volume and is released when the first shell element is breached. The device also includes a second shell element, which has a second enclosed cavity volume and also forms a low-permeability barrier. A second active pharmaceutical ingredient is contained in the second enclosed cavity volume. The device also includes an envelope element containing the first and second shell elements.
摘要翻译： 一种可植入药物递送装置，其使用多个储存元件来容纳和释放剂量的活性药物成分。 该装置包括第一壳单元，其具有第一封闭空腔体积并形成低渗透屏障。 第一壳元件被配置为吸收来自激光源的光照射，激光照射引起第一壳元件中的破裂。 第一活性药物成分包含在第一封闭空腔体积中，并且当第一壳元件被破坏时被释放。 该装置还包括第二壳单元，其具有第二封闭空腔体积并且还形成低渗透屏障。 第二活性药物成分包含在第二封闭空腔体积中。 该装置还包括包含第一和第二壳单元的包络元件。
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公开(公告)号：US08657804B2
公开(公告)日：2014-02-25
申请号：US12910572
申请日：2010-10-22
IPC分类号： A61M31/00
CPC分类号： A61F9/0017 , A61F2002/30714 , A61F2250/0068 , A61F2250/0089 , A61F2250/0097 , A61K9/0009 , A61K9/0051
摘要： The present disclosure relates to methods for visualizing the opening of a drug reservoir of an implantable medical device. In particular, the present disclosure provides methods for observing the release or exposure of contents from a drug reservoir of a medical device placed within the vitreous of an eye of a subject. The methods include implanting a drug delivery device within an anatomy of a subject. The drug device includes a plurality of reservoirs, each loaded with a therapeutic agent and a marker. Furthermore, the drug delivery device comprises a plurality of barrier layers for separating the contents of one of the plurality of reservoirs from the anatomy. The method further includes irradiating at least one of the plurality of barrier layers such that at least one of the plurality of reservoirs is breached, thereby triggering release of the therapeutic agent and the marker from the device. By visually detecting release of the marker into the anatomy, release of the therapeutic agent into the anatomy is verified.
摘要翻译： 本公开涉及用于可视化可植入医疗装置的药物储存器的开口的方法。 特别地，本公开提供了观察从放置在受试者的眼睛的玻璃体内的医疗装置的药物储存器释放或暴露内容物的方法。 所述方法包括将药物递送装置植入受试者的解剖结构内。 药物装置包括多个储存器，每个储存器装载有治疗剂和标记物。 此外，药物递送装置包括用于将多个储存器中的一个的内容物与解剖结构分离的多个阻挡层。 该方法还包括照射多个阻挡层中的至少一个，使得多个储存器中的至少一个被破坏，从而触发治疗剂和标记物从装置释放。 通过目视检测将标记物释放到解剖结构中，验证了治疗剂释放到解剖结构中。
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公开(公告)号：US20130303480A1
公开(公告)日：2013-11-14
申请号：US13880502
申请日：2011-10-13
IPC分类号： A61L31/04
CPC分类号： A61F2/0059 , A61L15/28 , A61L15/60 , A61L17/04 , A61L17/06 , A61L27/20 , A61L27/52 , A61L31/042 , A61L31/145 , A61L2430/34 , C08L5/00
摘要： This disclosure relates generally to soft tissue augmentation threads, methods of making such threads and uses thereof, for example, in aesthetic applications (e.g., facial contouring, soft tissue augmentation products), surgery (e.g., sutures), drug delivery, negative pressure wound therapy, moist wound dressing, and the like.
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公开(公告)号：US6004395A
公开(公告)日：1999-12-21
申请号：US994138
申请日：1997-12-19
申请人： Mark H. Yim , Warren B. Jackson , James G. Chase , David K. Biegelsen , Patrick C. P. Cheung , Andrew A. Berlin , Kenneth N. Horne
发明人： Mark H. Yim , Warren B. Jackson , James G. Chase , David K. Biegelsen , Patrick C. P. Cheung , Andrew A. Berlin , Kenneth N. Horne
CPC分类号： B65H5/228 , Y10T137/87812
摘要： A valve array for supporting objects such as paper with controlled fluid flow is disclosed. Optional valve arrays can be used to controllably eject marking agents for marking or coating a paper or other suitable substrate. Each valve in the valve array has one or more flap elements positioned in a valve chamber. These flap elements are movable to alternatively block the fluid flow through valve chamber outlets with the aid of various catch mechanisms for controllably latching the flap elements. The catch mechanisms have a disabled state and an activated state for holding and allowing release of the flap elements. Once the catch mechanism are disabled, the flap elements are free to move to another position, provided they can overcome the mechanical fluid flow forces that tend to hold it in position. To counter and utilize such forces for moving the flap elements, an impulse mechanism kicks the flap element into the valve chamber, away from the catch mechanisms. Since the position of the flap elements is unstable, oscillations of the flap elements in the fluid flow will eventually bring the flap element into catchment range of another catch mechanism in an activated state.
摘要翻译： 公开了一种用于支撑诸如具有受控流体流动的纸张的物体的阀阵列。 可选的阀阵列可用于可控地排出用于标记或涂覆纸张或其它合适基底的标记剂。 阀阵列中的每个阀具有位于阀室中的一个或多个挡板元件。 这些翼片元件可移动以借助于用于可控制地闩锁翼片元件的各种捕捉机构交替地阻挡通过阀室出口的流体流动。 捕捉机构具有禁用状态和用于保持并允许释放襟翼元件的激活状态。 一旦锁定机构被禁用，则翼片元件可自由地移动到另一位置，只要它们能够克服倾向于将其保持在适当位置的机械流体流动力即可。 为了抵抗和利用这种力来移动翼片元件，脉冲机构将翼片元件踢向阀室，远离捕捉机构。 由于襟翼元件的位置不稳定，因此流体流中的襟翼元件的振荡将最终使襟翼元件进入处于活动状态的另一掣子机构的集水区。
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6.发明申请THREADS OF CROSS-LINKED HYALURONIC ACID AND METHODS OF PREPARATION AND USE THEREOF 审中-公开交联氢氯酸的螺旋线及其制备及使用方法公开(公告)号：US20130274222A1
公开(公告)日：2013-10-17
申请号：US13880515
申请日：2011-10-13
IPC分类号： A61K8/73
CPC分类号： A61K8/735 , A61K8/027 , A61L15/28 , A61L27/20 , A61L31/042 , A61Q19/08 , C08B37/0072 , D01D5/38 , D01F1/10 , D01F9/00 , C08L5/08
摘要： This disclosure relates generally to cross-linked hyaluronic acid compositions, threads made from such compositions, methods of making such threads and uses thereof, for example, in aesthetic applications (e.g., facial contouring, soft tissue augmentation products), surgery (e.g., sutures), drug delivery, negative pressure wound therapy, moist wound dressing, and the like.
摘要翻译： 本公开一般涉及交联的透明质酸组合物，由这种组合物制成的丝线，制造这种丝线的方法及其用途，例如在美学应用（例如，面部轮廓，软组织增强产品），手术（例如缝线 ），药物递送，负压伤口治疗，潮湿伤口敷料等。
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公开(公告)号：US20130142731A1
公开(公告)日：2013-06-06
申请号：US13581902
申请日：2011-01-26
CPC分类号： A61L27/20 , A61B17/06166 , A61B2017/00747 , A61B2017/00893 , A61K8/02 , A61K8/0208 , A61K8/735 , A61K31/728 , A61K47/36 , A61L26/0023 , A61Q19/08 , B29C55/005 , B29K2005/00 , B29K2105/24 , B29L2031/753
摘要： This invention relates generally to threads of hyaluronic acid, methods of making such threads and uses thereof, for example, in aesthetic applications (e.g., facial contouring, dermal fillers), surgery (e.g., sutures), drug delivery, negative pressure wound therapy, moist wound dressing, and the like.
摘要翻译： 本发明一般涉及透明质酸的丝线，制造这种丝线的方法及其用途，例如在美学应用（例如面部轮廓，皮肤填充剂），手术（例如缝线），药物递送，负压伤口治疗， 湿润伤口敷料等。
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公开(公告)号：US20100179617A1
公开(公告)日：2010-07-15
申请号：US12688524
申请日：2010-01-15
IPC分类号： A61N1/08
CPC分类号： A61N1/37247 , A61N1/36075 , A61N1/36128 , A61N1/36142 , A61N1/37241 , A61N1/37282 , G06F19/00 , G16H40/63
摘要： Methods and apparatus for delivering therapy from an implanted neurostimulator to a patient are provided. One feature is an external controller that acts as a gateway for therapy. The external controller can be a handheld controller that communicates wirelessly with the implanted neurostimulator. In some embodiments, the controller communicates with a database to determine a therapy approval status of the neurostimulator. Therapy can be approved by a physician prescription, or by prepayment, for example. In some embodiments, the neurostimulator is deactivated when no approved therapies remain.
摘要翻译： 提供了从植入的神经刺激器向患者递送治疗的方法和装置。 一个特点是外部控制器充当治疗的门户。 外部控制器可以是与植入的神经刺激器无线通信的手持控制器。 在一些实施例中，控制器与数据库通信以确定神经刺激器的治疗批准状态。 治疗可以由医生处方批准，或通过预付款来批准。 在一些实施例中，当没有批准的治疗保留时，神经刺激器被停用。
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公开(公告)号：US09615914B2
公开(公告)日：2017-04-11
申请号：US13277464
申请日：2011-10-20
申请人： Kenneth N. Horne , Michael H. Rosenthal , Geoffrey C. Gurtner , Christopher S. Jones , Sergio Salinas , Joseph Rimsa
发明人： Kenneth N. Horne , Michael H. Rosenthal , Geoffrey C. Gurtner , Christopher S. Jones , Sergio Salinas , Joseph Rimsa
CPC分类号： A61F2/12 , A61B17/00 , A61B2017/00792 , A61B2017/00796 , A61B2017/00876 , A61F2002/526 , A61F2210/009 , A61H2205/082 , A61J13/00
摘要： Apparatus and methods for nipple and breast formation are described where devices precondition or expand a target nipple tissue to reduce the pressure exerted by the skin on an eventual implant. Generally, the apparatus comprises a mold having a contact surface which is curved in conformance with a breast upon which the mold is positionable, the contact surface having an adhesive for securement upon the breast, and the mold defining a cavity along the contact surface which conforms to a size of a nipple to be formed upon the breast and where the cavity further comprises the adhesive for securement to the nipple. A breast enlargement device comprises a cup larger than the target breast and further defines an inner surface which adheres to the breast when contacted.
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公开(公告)号：US09320908B2
公开(公告)日：2016-04-26
申请号：US12688524
申请日：2010-01-15
CPC分类号： A61N1/37247 , A61N1/36075 , A61N1/36128 , A61N1/36142 , A61N1/37241 , A61N1/37282 , G06F19/00 , G16H40/63
摘要： Methods and apparatus for delivering therapy from an implanted neurostimulator to a patient are provided. One feature is an external controller that acts as a gateway for therapy. The external controller can be a handheld controller that communicates wirelessly with the implanted neurostimulator. In some embodiments, the controller communicates with a database to determine a therapy approval status of the neurostimulator. Therapy can be approved by a physician prescription, or by prepayment, for example. In some embodiments, the neurostimulator is deactivated when no approved therapies remain.
摘要翻译： 提供了从植入的神经刺激器向患者递送治疗的方法和装置。 一个特点是外部控制器充当治疗的门户。 外部控制器可以是与植入的神经刺激器无线通信的手持控制器。 在一些实施例中，控制器与数据库通信以确定神经刺激器的治疗批准状态。 治疗可以由医生处方批准，或通过预付款来批准。 在一些实施例中，当没有批准的治疗保留时，神经刺激器被停用。
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