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![Salts of (R)-7-[3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-trifluoromethyl-5,6,7,8-tetrahydroimidazo[1,5-a] pyrazine-1-carboxylic acid, preparation method and medical use thereof](/abs-image/US/2013/08/27/US08518946B2/abs.jpg.150x150.jpg)
1.发明授权Salts of (R)-7-[3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-trifluoromethyl-5,6,7,8-tetrahydroimidazo[1,5-a] pyrazine-1-carboxylic acid, preparation method and medical use thereof 有权（R）-7- [3-氨基-4-（2,4,5-三氟苯基）丁酰基] -3-三氟甲基-5,6,7,8-四氢咪唑并[1,5-a]吡嗪-1 - 羧酸，其制备方法和医疗用途公开(公告)号：US08518946B2
公开(公告)日：2013-08-27
申请号：US13225050
申请日：2011-09-02
申请人： Peng Cho Tang , Piaoyang Sun , Fanglong Yang , Jindong Liang , Guangyuan Shen , Yang Wang , Jiang Fan
发明人： Peng Cho Tang , Piaoyang Sun , Fanglong Yang , Jindong Liang , Guangyuan Shen , Yang Wang , Jiang Fan
IPC分类号： A61K31/495
CPC分类号： C07D487/04
摘要： Pharmaceutically acceptable salts of (R)-7-[3-amino-4-(2,4,5-trifluorophenyl)-butyryl]-3-trifluoromethyl-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1-formic acid, their preparation methods, compositions containing the said pharmaceutical salts and their use as medicaments, especially as dipeptidyl peptidase IV (DPP-IV) inhibitors are disclosed. Of the many acceptable salts, one example is the following.
摘要翻译： （R）-7- [3-氨基-4-（2,4,5-三氟苯基） - 丁酰基] -3-三氟甲基-5,6,7,8-四氢 - 咪唑并[1,5- a]吡嗪-1-甲酸，其制备方法，含有所述药物盐的组合物及其作为药物的用途，特别是作为二肽基肽酶IV（DPP-IV）抑制剂。 在许多可接受的盐中，一个例子如下。
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2.发明申请C-ARYL GLUCOSIDE DERIVATIVES, PREPARATION PROCESS AND PHARMACEUTICAL USE THEREOF 有权C-ARYL GLUCOSIDE衍生物，其制备方法及其药物用途公开(公告)号：US20130130997A1
公开(公告)日：2013-05-23
申请号：US13813045
申请日：2011-06-30
申请人： Fanglong Yang , Peng Cho Tang , Qing Dong , Wangyang Tu , Jiang Fan , Dongliang Guan , Guangyuan Shen , Yang Wang , Jijun Yuan , Limin Zhang
发明人： Fanglong Yang , Peng Cho Tang , Qing Dong , Wangyang Tu , Jiang Fan , Dongliang Guan , Guangyuan Shen , Yang Wang , Jijun Yuan , Limin Zhang
IPC分类号： C07H17/04
摘要： C-aryl glucoside derivatives, preparation processes and pharmaceutical uses thereof are disclosed. In particular, C-aryl glucoside derivatives represented by formula (I), with each substituent defined in the application, pharmaceutically acceptable salts or stereoisomers thereof, their preparation methods, and pharmaceutical compositions containing the derivatives as well as their uses as therapeutic agents, particularly as sodium-dependent glucose cotransporter (SGLT)-1 inhibitors, are disclosed.
摘要翻译： 公开了C-芳基葡糖苷衍生物，其制备方法及其药物用途。 特别地，式（I）表示的C芳基葡糖苷衍生物与本申请中定义的每个取代基，其药学上可接受的盐或立体异构体，其制备方法和含有衍生物的药物组合物及其用作治疗剂，特别是 作为钠依赖性葡萄糖转运蛋白（SGLT）-1抑制剂。
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3.发明授权Dicycloazaalkane derivatives, preparation processes and medical uses thereof 有权二环烷基烷烃衍生物，其制备方法和医疗用途公开(公告)号：US08415349B2
公开(公告)日：2013-04-09
申请号：US13619138
申请日：2012-09-14
申请人： Peng Cho Tang , Zhigang Lin , Hejun Lü , Fuqiang Zhao , Li Li , Fanglong Yang , Jianghong Fu , Lin Wang , Guangyuan Shen , Dongliang Guan
发明人： Peng Cho Tang , Zhigang Lin , Hejun Lü , Fuqiang Zhao , Li Li , Fanglong Yang , Jianghong Fu , Lin Wang , Guangyuan Shen , Dongliang Guan
IPC分类号： A61K31/5377 , A61K31/403 , A61K31/454 , C07D403/12 , C07D401/14 , C07D413/14
CPC分类号： C07D209/52 , C07D403/12
摘要： The invention provides derivatives of azabicyclo alkane having formula (ID), and the method for making them, wherein each substitute in formula (ID) is same as defined in the description.
摘要翻译： 本发明提供具有式（ID）的氮杂双环烷烃衍生物及其制备方法，其中式（ID）中的每个取代基与说明书中定义相同。
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4.发明申请DICYCLOAZAALKANE DERIVATES, PREPARATION PROCESSES AND MEDICAL USES THEREOF 有权DICYCLOAZAALKANE衍生物，其制备方法及其医疗用途公开(公告)号：US20100311747A1
公开(公告)日：2010-12-09
申请号：US12863964
申请日：2008-05-20
申请人： Peng Cho Tang , Zhigang Lin , Hejun Lu , Fuqiang Zhao , Li Li , Fanglong Yang , Jianghong Fu , Lin Wang , Guangyuan Shen , Dongliang Guan
发明人： Peng Cho Tang , Zhigang Lin , Hejun Lu , Fuqiang Zhao , Li Li , Fanglong Yang , Jianghong Fu , Lin Wang , Guangyuan Shen , Dongliang Guan
IPC分类号： A61K31/5377 , C07D403/12 , A61K31/403 , C07D401/14 , A61K31/454 , C07D413/14 , A61P3/10
CPC分类号： C07D209/52 , C07D403/12
摘要： Disclosed are new dicycloazaalkane derivates represented by general formula (I), preparation processes and pharmaceutical compositions containing them, and the uses for treatment especially for dipeptidyl peptidase inhibitor (DPP-IV), in which each substitute group of general formula (I) is as defined in specification.
摘要翻译： 公开了由通式（I）表示的新的二环唑烷衍生物，其制备方法和含有它们的药物组合物，以及特别用于二肽基肽酶抑制剂（DPP-IV）的用途，其中通式（I）的每个取代基为 在规范中定义。
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5.发明授权C-aryl glucoside derivatives, preparation process and pharmaceutical use thereof 有权C-芳基葡糖苷衍生物，其制备方法和药物用途公开(公告)号：US08609622B2
公开(公告)日：2013-12-17
申请号：US13813045
申请日：2011-06-30
申请人： Fanglong Yang , Peng Cho Tang , Qing Dong , Wangyang Tu , Jiang Fan , Dongliang Guan , Guangyuan Shen , Yang Wang , Jijun Yuan , Limin Zhang
发明人： Fanglong Yang , Peng Cho Tang , Qing Dong , Wangyang Tu , Jiang Fan , Dongliang Guan , Guangyuan Shen , Yang Wang , Jijun Yuan , Limin Zhang
摘要： C-aryl glucoside derivatives, preparation processes and pharmaceutical uses thereof are disclosed. In particular, C-aryl glucoside derivatives represented by formula (I), with each substituent defined in the application, pharmaceutically acceptable salts or stereoisomers thereof, their preparation methods, and pharmaceutical compositions containing the derivatives as well as their uses as therapeutic agents, particularly as sodium-dependent glucose cotransporter (SGLT)-1 inhibitors, are disclosed.
摘要翻译： 公开了C-芳基葡糖苷衍生物，其制备方法及其药物用途。 特别地，式（I）表示的C芳基葡糖苷衍生物与本申请中定义的每个取代基，其药学上可接受的盐或立体异构体，其制备方法和含有衍生物的药物组合物及其用作治疗剂，特别是 作为钠依赖性葡萄糖转运蛋白（SGLT）-1抑制剂。
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6.发明申请DICYCLOAZAALKANE DERIVATIVES, PREPARATION PROCESSES AND MEDICAL USES THEREOF 有权DICYCLOAZAALKANE衍生物，其制备方法及其医疗用途公开(公告)号：US20130012705A1
公开(公告)日：2013-01-10
申请号：US13619138
申请日：2012-09-14
申请人： Peng Cho Tang , Zhigang Lin , Hejun Lü , Fuqiang Zhao , Li Li , Fanglong Yang , Jianghong Fu , Lin Wang , Guangyuan Shen , Dongliang Guan
发明人： Peng Cho Tang , Zhigang Lin , Hejun Lü , Fuqiang Zhao , Li Li , Fanglong Yang , Jianghong Fu , Lin Wang , Guangyuan Shen , Dongliang Guan
IPC分类号： C07D209/52 , C07D413/06 , C07D403/06 , C07D401/06
CPC分类号： C07D209/52 , C07D403/12
摘要： Disclosed are new dicycloazaalkane derivates represented by general formula (I), preparation processes and pharmaceutical compositions containing them, and the uses for treatment especially for dipeptidyl peptidase inhibitor (DPP-IV), in which each substitute group of general formula (I) is as defined in specification.
摘要翻译： 公开了由通式（I）表示的新的二环唑烷衍生物，其制备方法和含有它们的药物组合物，以及特别用于二肽基肽酶抑制剂（DPP-IV）的用途，其中通式（I）的每个取代基为 在规范中定义。
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![TETRAHYDRO-IMIDAZO[1,5-a]PYRAZINE DERIVATIVES SALTS, PREPARATION METHODS AND MEDICINAL USE THEREOF](/abs-image/US/2012/03/15/US20120065209A1/abs.jpg.150x150.jpg)
7.发明申请TETRAHYDRO-IMIDAZO[1,5-a]PYRAZINE DERIVATIVES SALTS, PREPARATION METHODS AND MEDICINAL USE THEREOF 有权四氢咪唑并[1,5-a]吡嗪衍生物盐，其制备方法和药物用途公开(公告)号：US20120065209A1
公开(公告)日：2012-03-15
申请号：US13225050
申请日：2011-09-02
申请人： Peng Cho Tang , Piaoyang Sun , Fanglong Yang , Jindong Liang , Guangyuan Shen , Yang Wang , Jiang Fan
发明人： Peng Cho Tang , Piaoyang Sun , Fanglong Yang , Jindong Liang , Guangyuan Shen , Yang Wang , Jiang Fan
IPC分类号： A61K31/4985 , C12N9/99 , A61P3/10 , A61P3/04 , C07D487/04 , A61P5/50
CPC分类号： C07D487/04
摘要： Pharmaceutically acceptable salts of (R)-7-[3-amino-4-(2,4,5-trifluorophenyl)-butyryl]-3-trifluoromethyl-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1-formic acid, their preparation methods, compositions containing the said pharmaceutical salts and their use as medicaments, especially as dipeptidyl peptidase IV (DPP-IV) inhibitors are disclosed.
摘要翻译： （R）-7- [3-氨基-4-（2,4,5-三氟苯基） - 丁酰基] -3-三氟甲基-5,6,7,8-四氢 - 咪唑并[1,5- a]吡嗪-1-甲酸，其制备方法，含有所述药物盐的组合物及其作为药物的用途，特别是作为二肽基肽酶IV（DPP-IV）抑制剂。
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8.发明授权公开(公告)号：US08304411B2
公开(公告)日：2012-11-06
申请号：US12863964
申请日：2008-05-20
申请人： Peng Cho Tang , Zhigang Lin , Hejun Lu , Fuqiang Zhao , Li Li , Fanglong Yang , Jianghong Fu , Lin Wang , Guangyuan Shen , Dongliang Guan
发明人： Peng Cho Tang , Zhigang Lin , Hejun Lu , Fuqiang Zhao , Li Li , Fanglong Yang , Jianghong Fu , Lin Wang , Guangyuan Shen , Dongliang Guan
IPC分类号： A61K31/5377 , A61K31/403 , A61K31/454 , C07D403/12 , C07D401/14 , C07D413/14 , A61P3/10
CPC分类号： C07D209/52 , C07D403/12
摘要： Disclosed are new dicycloazaalkane derivates represented by general formula (I), preparation processes and pharmaceutical compositions containing them, and the uses for treatment especially for dipeptidyl peptidase inhibitor (DPP-IV), in which each substitute group of general formula (I) is as defined in specification.
摘要翻译： 公开了由通式（I）表示的新的二环扎烷烃衍生物，其制备方法和含有它们的药物组合物，以及特别用于二肽基肽酶抑制剂（DPP-IV）的用途，其中通式（I）的每个取代基为 在规范中定义。
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