公开(公告)号：US6048875A

公开(公告)日：2000-04-11

申请号：US299271

申请日：1999-04-26

申请人： Guillaume De Manteuil ,  Christine Lila ,  Tony Verbeuren ,  Alain Rupin

发明人： Guillaume De Manteuil ,  Christine Lila ,  Tony Verbeuren ,  Alain Rupin

IPC分类号： C07D333/58 ,  A61K31/00 ,  A61K31/38 ,  A61K31/381 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/505 ,  A61K31/506 ,  A61P7/00 ,  A61P7/02 ,  A61P43/00 ,  C07D333/60 ,  C07D333/64 ,  C07D401/06 ,  C07D405/06 ,  C07D405/14 ,  C07D409/06 ,  C07D409/14 ,  C07D495/04 ,  C07D521/00

CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D333/64 ,  C07D401/06 ,  C07D409/06 ,  C07D409/14

摘要： A compound of formula (I): ##STR1## wherein: X represents oxygen, sulphur, or NR.sub.3 wherein R.sub.3 is as defined in the description,Y represents oxygen, sulphur, NR.sub.3, or may a single bond when X represents NR.sub.3,Z represents nitrogen, carbon, or CH,A represents a single bond, alkylene (optionally substituted), arylene, cycloalkylene, heterocycle, or --SO.sub.2 --R.sub.4 -- wherein R.sub.4 is as defined in the description,W represents hydroxy, alkoxy, aryloxy, arylalkoxy, cycloalkyloxy, heterocycle bonded to oxygen, amino, or hydroxyamino,Ra, Rb, Rc, Rd, which may be the same or different, each independently of the others are as defined in the description,R.sub.1 represents aryl substituted by one to five identical or different substituents, each independently of the others,R.sub.2 represents hydrogen, alkyl, aryl, arylalkyl, cycloalkyl, heterocycle, heterocycloalkyl, or another group as defined in the description,isomers and addition salts thereof with a pharmaceutically-acceptable acid or base, and medicinal products containing the same which are useful in the treatment of thrombosis, pathologies for which the origin is thrombosis, or pathologies causing an increase in risk of thrombosis.

摘要翻译： 式（I）的化合物：其中：X表示氧，硫或NR 3，其中R3如说明书中所定义，Y表示氧，硫，NR 3，或当X表示NR 3时可以是单键，Z表示氮，碳 或CH，A表示单键，亚烷基（任选取代的），亚芳基，亚环烷基，杂环或-SO 2 -R 4 - ，其中R 4如说明书中所定义，W表示羟基，烷氧基，芳氧基，芳基烷氧基，环烷氧基，杂环 与氧，氨基或羟基氨基键合的R a，R b，R c，R d各自独立地相同或不同，如说明书中所定义，R 1表示被1至5个相同或不同取代基取代的芳基， R 2代表氢，烷基，芳基，芳基烷基，环烷基，杂环，杂环烷基或说明书中定义的另一基团，其与药学上可接受的酸或碱的异构体和加成盐，以及药用产品 可用于治疗血栓形成，起源于血栓形成的病理学，或导致血栓形成风险增加的病理学。