公开(公告)号：US20110245456A1

公开(公告)日：2011-10-06

申请号：US13158798

申请日：2011-06-13

申请人： Gun Poong Kim ,  Yong Hoon Lee ,  Kun Pil Lee

发明人： Gun Poong Kim ,  Yong Hoon Lee ,  Kun Pil Lee

IPC分类号： C08G63/06 ,  B29B9/12

CPC分类号： C08F6/00 ,  B29B9/12 ,  B29B2009/125 ,  C08G63/06 ,  C08J3/122 ,  C08J3/14 ,  C08J2367/04 ,  Y10T428/2989

摘要： The present invention relates to a preparation method for a biodegradable polymer microparticle and a microparticle prepared by the method. More particularly, the present invention relates to a method for preparing a polymer microparticle, wherein the method includes the steps of: dissolving a biodegradable polyester-based polymer in DMSO (Dimethyl Sulfoxide); spraying the solution in a low temperature hydrocarbon solution to provide a frozen DMSO microparticle; adding the microparticle in a low temperature salt aqueous solution to dissolve DMSO; and removing salt. The present invention provides a method for preparing a novel polymer microsphere which can be injected through a syringe due to excellent physical properties (such as biocompatibility, biodegradability, porosity, mechanical strength) and the microcarrier's size-adjustability, and can be easily mass-produced. The microparticle prepared by the method of the present invention may have variable sizes with biodegradability and biocompatibility, and thus can be used as a carrier for regeneration of a damaged cell or tissue by being injected into a body through a syringe.

摘要翻译： 本发明涉及通过该方法制备的生物可降解聚合物微粒和微粒的制备方法。 更具体地说，本发明涉及一种制备聚合物微粒的方法，其中该方法包括以下步骤：将可生物降解的聚酯类聚合物溶于DMSO（二甲基亚砜）中; 将溶液喷洒在低温烃溶液中以提供冷冻的DMSO微粒; 将微粒加入低温盐水溶液中以溶解DMSO; 并去除盐。 本发明提供一种制备新型聚合物微球体的方法，该方法由于物理性能（生物相容性，生物降解性，孔隙率，机械强度）和微载体尺寸可调性等优异的物理性能而能够通过注射器注射，并且可以容易地批量生产 。 通过本发明的方法制备的微粒可以具有可生物降解性和生物相容性的可变大小，因此可以通过注射器注入体内作为受损细胞或组织再生的载体。

公开(公告)号：US08329856B2

公开(公告)日：2012-12-11

申请号：US13158798

申请日：2011-06-13

申请人： Gun Poong Kim ,  Yong Hoon Lee ,  Kun Pil Lee

发明人： Gun Poong Kim ,  Yong Hoon Lee ,  Kun Pil Lee

IPC分类号： C08F6/00

CPC分类号： C08F6/00 ,  B29B9/12 ,  B29B2009/125 ,  C08G63/06 ,  C08J3/122 ,  C08J3/14 ,  C08J2367/04 ,  Y10T428/2989

摘要： The present invention relates to a preparation method for a biodegradable polymer microparticle and a microparticle prepared by the method. More particularly, the present invention relates to a method for preparing a polymer microparticle, wherein the method includes the steps of: dissolving a biodegradable polyester-based polymer in DMSO (Dimethyl Sulfoxide); spraying the solution in a low temperature hydrocarbon solution to provide a frozen DMSO microparticle; adding the microparticle in a low temperature salt aqueous solution to dissolve DMSO; and removing salt. The present invention provides a method for preparing a novel polymer microsphere which can be injected through a syringe due to excellent physical properties (such as biocompatibility, biodegradability, porosity, mechanical strength) and the microcarrier's size-adjustability, and can be easily mass-produced. The microparticle prepared by the method of the present invention may have variable sizes with biodegradability and biocompatibility, and thus can be used as a carrier for regeneration of a damaged cell or tissue by being injected into a body through a syringe.

摘要翻译： 本发明涉及通过该方法制备的生物可降解聚合物微粒和微粒的制备方法。 更具体地说，本发明涉及一种制备聚合物微粒的方法，其中该方法包括以下步骤：将可生物降解的聚酯类聚合物溶于DMSO（二甲基亚砜）中; 将溶液喷洒在低温烃溶液中以提供冷冻的DMSO微粒; 将微粒加入低温盐水溶液中以溶解DMSO; 并去除盐。 本发明提供一种制备新型聚合物微球体的方法，该方法由于物理性能（生物相容性，生物降解性，孔隙率，机械强度）和微载体尺寸可调性等优异的物理性能而能够通过注射器注射，并且可以容易地批量生产 。 通过本发明的方法制备的微粒可以具有可生物降解性和生物相容性的可变大小，因此可以通过注射器注入体内作为受损细胞或组织再生的载体。