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    Vitamin d upregulated protein 1 (vdup-) methods and uses thereof
    3.
    发明申请
    Vitamin d upregulated protein 1 (vdup-) methods and uses thereof 审中-公开
    维生素d上调蛋白1（vdup-）方法及其用途

    公开(公告)号：US20050143357A1

    公开(公告)日：2005-06-30

    申请号：US10505665

    申请日：2003-02-25

    申请人： Ake Pousette ,  Gunnar Norstedt ,  Jacob Pang

    发明人： Ake Pousette ,  Gunnar Norstedt ,  Jacob Pang

    IPC分类号： A61K31/59 ,  A61K38/17 ,  A61K45/06 ,  A61P13/08 ,  G01N33/50 ,  G01N33/574 ,  C12Q1/68 ,  C07H21/04 ,  C07K14/72

    CPC分类号： G01N33/57434 ,  A61K31/59 ,  A61K38/1709 ,  A61K45/06 ,  G01N33/5011 ,  A61K2300/00

    摘要： A method for selecting a compound or a composition of matter for treatment of hyperproliferative disorders of the prostate in a mammal by administering the compound or the composition to a mammal (in vivo) or to a prostate cell culture (in vitro) and assessing the effect of the compound or the composition on the content of the transcription and/or translation product of a gene under the influence of at least one regulatory region of Vitamin D upregulated protein 1 (VDUP-1) gene and optionally assessing the effect of the compound or the composition on the content of apoptosis signalling kinase (ASK-1) and/or thioredoxin, in the prostate cells of said mammal or in the cells of the prostate cell culture. A substance for use in the treatment of hyperproliferative disorders of the prostate selected by the above method, a pharmaceutical composition comprising said substance, a method of treatment by of a hyperproliferative disorder of the prostate. A gene encoding VDUP-1 or a functional equivalent thereof for use as a medicament and a vector capable of expressing VDUP-1. A method of diagnosis of a hyperproliferative disorder of the prostate in a mammal by assessing the content of the transcription and/or translation products of at least one of the genes encoding ezrin, thioredoxin, peroxiredoxin 5, cyclin-dependent kinase 4, growth response protein CL6, defender against cell death 1, CD24, osteoactivin, vitamin D-upregulated protein 1, placental growth factor gene 1+2, Gata-4, duffy blood antigen, interferon-inducible 17-kDa membrane protein, 14-3-3 protein, CD9 antigen (p24), Ste-20 related kinase, ephrin type A receptor 5 precursor, programmed cell death factor 4 and DNA-methyltransferase 3a, in cells obtained from the prostate of said mammal. A kit for use in a method of diagnosis of a hyperproliferative disorder of the prostate in a mammal.

    摘要翻译： 一种用于通过将哺乳动物（体内）或前列腺细胞培养物（体外）施用该化合物或组合物或在体外给予前列腺细胞培养物（体外）来选择用于治疗哺乳动物过度增生性疾病的物质的化合物或组合物的方法， 的化合物或组合物在维生素D上调蛋白1（VDUP-1）基因的至少一个调节区域的影响下的基因的转录和/或翻译产物的含量，并任选地评估化合物的作用或 在所述哺乳动物的前列腺细胞或前列腺细胞培养物的细胞中的凋亡信号激酶（ASK-1）和/或硫氧还蛋白的含量的组成。 用于治疗通过上述方法选择的前列腺增生性疾病的物质，包含所述物质的药物组合物，通过前列腺过度增生性病症治疗的方法。 编码VDUP-1或其功能等同物的基因用作药物和能够表达VDUP-1的载体。 通过评估编码ezrin，硫氧还蛋白，过氧氧化还原酶5，细胞周期蛋白依赖性激酶4，生长反应蛋白质的至少一种基因的转录和/或翻译产物的含量来诊断哺乳动物中前列腺过度增生性疾病的方法 CL6，抗细胞死亡防御1，CD24，骨诱导因子，维生素D上调蛋白1，胎盘生长因子基因1 + 2，Gata-4，duffy血液抗原，干扰素诱导型17-kDa膜蛋白，14-3-3蛋白 ，CD9抗原（p24），Ste-20相关激酶，ephrin A型受体5前体，程序性细胞死亡因子4和DNA-甲基转移酶3a在从所述哺乳动物前列腺获得的细胞中。 用于诊断哺乳动物前列腺过度增生性疾病的方法的试剂盒。