公开(公告)号：US08101200B2

公开(公告)日：2012-01-24

申请号：US09834307

申请日：2001-04-12

Applicant: Richard J. Whitbourne ,  Daniel Hullihen ,  Michael R. Violante ,  Frank Guo-Bin Wang ,  Xianping Zhang

Inventor： Richard J. Whitbourne ,  Daniel Hullihen ,  Michael R. Violante ,  Frank Guo-Bin Wang ,  Xianping Zhang

IPC: A61F2/00

CPC classification number: A61K9/0024 ,  A61L27/34 ,  A61L27/54 ,  A61L2300/414 ,  A61L2300/416 ,  A61L2300/606

Abstract: Generally, the present invention provides devices and methods for delivering high, efficacious concentrations of therapeutic agents, i.e., medicaments such as drugs, antibiotics, etc., to specific sites in a patient's body, such as tumors and infected lesions. In one aspect of the present invention there are provided devices to accomplish the aforesaid delivery of therapeutic agents and methods to accomplish the delivery by positioning a device in the body using minimally invasive techniques such as, for example, catheterization or via trochar. The devices may contain a carrier substrate and a coating on the substrate. The carrier substrate provides structural integrity to the device and the coating thereon contains at least one layer of polymeric material containing one or more medicaments. Optionally, there may be a non-medicated binder coat between the carrier substrate and the medicated polymer layer. The medicated polymer layer may contain a hydrophilic/hydrophobic polymer composition.

Abstract translation: 通常，本发明提供了用于将高效，有效浓度的治疗剂（例如药物，抗生素等）的药物递送到患者体内的特定部位（例如肿瘤和感染的病变）的装置和方法。 在本发明的一个方面，提供了用于实现上述递送治疗剂的装置和通过使用微创技术（例如导管插入术或定位装置）将装置定位在体内来实现递送的方法。 所述装置可以包含载体基底和基底上的涂层。 载体基底为装置提供结构完整性，并且其上的涂层包含至少一层含有一种或多种药物的聚合材料层。 任选地，在载体基质和含药聚合物层之间可以存在非药物粘合剂涂层。 含药聚合物层可以含有亲水/疏水聚合物组合物。

公开(公告)号：US06358557B1

公开(公告)日：2002-03-19

申请号：US09394577

申请日：1999-09-10

Applicant: Guo-Bin Wang ,  Xianping Zhang

Inventor： Guo-Bin Wang ,  Xianping Zhang

IPC: B05D310

CPC classification number: B05D1/18 ,  A61L29/085

Abstract: The invention includes a method of coating a substrate, comprising exposing a substrate to an initiator capable of initiating a graft polymerization reaction on the substrate, to generate reactive radical sites on the surface of the substrate; contacting the substrate with a composition comprising one or more monomers in a medium which has different hydrophilicity compared to the substrate, and grafting monomer molecules onto the substrate by forming covalent bonds between monomer molecules and the substrate at reactive radical sites on the substrate surface. With the invention, novel coated articles can be obtained which are particularly usefull as medical products such as catheters.

Abstract translation: 本发明包括一种涂覆基质的方法，包括将底物暴露于能够在基底上引发接枝聚合反应的引发剂，以在基底表面产生反应性基团位点; 在与基材相比具有不同亲水性的介质中将基材与包含一种或多种单体的组合物接触，以及通过在基材表面上的反应性基团位置处在单体分子和基材之间形成共价键将单体分子接枝到基材上。 通过本发明，可以获得作为医疗产品如导管特别有用的新型涂层制品。

公开(公告)号：US20090192049A1

公开(公告)日：2009-07-30

申请号：US12414048

申请日：2009-03-30

Applicant: Cheryl L. Baird ,  Guo Bin Wang ,  Lance Laing ,  Gangadhar Jogikalmath ,  John Gerstenmaier

Inventor： Cheryl L. Baird ,  Guo Bin Wang ,  Lance Laing ,  Gangadhar Jogikalmath ,  John Gerstenmaier

IPC: C40B30/04 ,  G01N21/55 ,  G01N21/59 ,  G01N21/41

CPC classification number: G01N33/5432 ,  G01N33/54373 ,  G01N33/551 ,  G01N33/92

Abstract: The invention provides compositions and methods for detection of interaction of molecules.

Abstract translation: 本发明提供了用于检测分子相互作用的组合物和方法。