公开(公告)号：US20100297622A1

公开(公告)日：2010-11-25

申请号：US12469105

申请日：2009-05-20

申请人： Honghua Li ,  Guohong Hu ,  Qifeng Yang

发明人： Honghua Li ,  Guohong Hu ,  Qifeng Yang

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6844 ,  C12Q2565/501 ,  C12Q2549/119 ,  C12Q2537/143

摘要： The present invention embraces a method for high-throughput gene profiling with high specificity and sensitivity. With this system, >1000 mRNA species can be co-amplified using gene-specific primers from a single cell. The primers are designed to amplify sequences of desirable length, which are in different exons. The exons can be either adjacent and separated by a large intron or include more than two exons. The amplified sequences are then analyzed by microarray with probes hybridizing to neighboring exons.

摘要翻译： 本发明包括具有高特异性和灵敏度的高通量基因谱学方法。 使用该系统，可以使用来自单细胞的基因特异性引物共扩增> 1000个mRNA种类。 引物设计用于扩增所需长度的序列，其在不同的外显子中。 外显子可以相邻并由大的内含子分开或包含两个以上的外显子。 然后通过与相邻外显子杂交的探针的微阵列分析扩增的序列。

公开(公告)号：US20090324596A1

公开(公告)日：2009-12-31

申请号：US12215998

申请日：2008-06-30

申请人： Yibin Kang ,  Guohong Hu

发明人： Yibin Kang ,  Guohong Hu

IPC分类号： A61K39/395 ,  A61K31/7105 ,  C12Q1/68 ,  G06F19/00

CPC分类号： C12N15/1135 ,  A61K31/00 ,  A61K31/337 ,  A61K31/704 ,  A61K31/7105 ,  A61K31/713 ,  A61K45/06 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2320/30 ,  C12N2320/31 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/156

摘要： The present invention relates generally to methods for identifying cancer patients with a poor prognosis, and to therapeutic modalities for improving prognosis by combating metastasis and abrogating chemoresistance in cancer cells. Embodiments of the present invention provide an objective means of prognostication regarding the long-term outcome of an incident of cancer, breast cancer in particular. Therapeutic modalities include immunotherapy and anti-sense therapy. Prognosis is determined by measuring the number of copies of the metadherin gene in the patient's cells.

摘要翻译： 本发明一般涉及用于鉴定癌预后不良的癌症患者的方法，以及用于通过抵抗转移和消除癌细胞中的化学耐药性来改善预后的治疗方式。 本发明的实施例提供了关于癌症事件，特别是乳腺癌事件的长期结果的预测的客观手段。 治疗方式包括免疫治疗和反感疗法。 通过测量患者细胞中metadherin基因的拷贝数确定预后。

公开(公告)号：US20120205505A1

公开(公告)日：2012-08-16

申请号：US13503472

申请日：2009-12-18

申请人： Zbigniew Piech ,  Guohong Hu

发明人： Zbigniew Piech ,  Guohong Hu

IPC分类号： B66B13/30 ,  E05C19/16 ,  B23P11/00 ,  H01F7/02

CPC分类号： H01F7/04 ,  B66B13/12 ,  E05F15/60 ,  E05Y2900/104 ,  Y10T24/32 ,  Y10T29/49826 ,  Y10T292/11

摘要： An exemplary locking or coupling device includes a plurality of magnets each having a direction of magnetization. A plurality of pole shoe members are positioned between selected ones of the magnets. A moveable support supports some of the magnets and some of the pole shoe members. The moveable support is moveable to selectively change a relative orientation of the directions of magnetization. One relative orientation primarily directs a flow of magnetic flux between the magnets through the pole shoe members and the magnetic flux remains essentially in a plane containing the magnets and the pole shoe members. A second, different relative orientation primarily directs the flow of magnetic flux from the pole shoe members in a transverse direction away from the plane.

摘要翻译： 示例性的锁定或耦合装置包括各自具有磁化方向的多个磁体。 多个极靴构件位于选定的磁体之间。 可移动支撑件支撑一些磁体和一些极靴构件。 可移动支撑件可移动以选择性地改变磁化方向的相对取向。 一个相对取向主要通过极靴构件引导磁体之间的磁通量，并且磁通量基本上保持在包含磁体和极靴构件的平面内。 第二个不同的相对方向主要是指导从极靴构件的磁通量在远离平面的横向方向上的流动。

公开(公告)号：US09731941B2

公开(公告)日：2017-08-15

申请号：US13697046

申请日：2010-11-30

申请人： Jinkoo Lee ,  Jung Sam Kim ,  Byeong Sam Yoo ,  Hansoo Shim ,  Guohong Hu ,  Mark Steven Thompson

发明人： Jinkoo Lee ,  Jung Sam Kim ,  Byeong Sam Yoo ,  Hansoo Shim ,  Guohong Hu ,  Mark Steven Thompson

IPC分类号： B66B13/24 ,  E05F5/02 ,  E05F15/632 ,  E05F5/00 ,  B66B13/06

CPC分类号： B66B13/24 ,  B66B13/06 ,  B66B13/26 ,  E05F5/003 ,  E05F15/632

摘要： A device for inhibiting the closing of a door that controls entry of an enclosure includes a first magnet disposed on a driven portion of the device and a second magnet disposed on a fixed portion of the enclosure. The first magnet and the second magnet are configured to be in register with each other as the door moves toward a closed position such that if the first magnet and the second magnet are in register with each other, a pole of the first magnet is in close proximity of a pole of the second magnet such that the first magnet and the second magnet react to each other to inhibit motion of the door towards the closed position.

公开(公告)号：US09362037B2

公开(公告)日：2016-06-07

申请号：US13503472

申请日：2009-12-18

申请人： Zbigniew Piech ,  Guohong Hu

发明人： Zbigniew Piech ,  Guohong Hu

IPC分类号： E05C17/56 ,  H01F7/04 ,  B66B13/12 ,  E05F15/60 ,  E05C19/16

CPC分类号： H01F7/04 ,  B66B13/12 ,  E05F15/60 ,  E05Y2900/104 ,  Y10T24/32 ,  Y10T29/49826 ,  Y10T292/11

摘要： An exemplary locking or coupling device includes a plurality of magnets each having a direction of magnetization. A plurality of pole shoe members are positioned between selected ones of the magnets. A moveable support supports some of the magnets and some of the pole shoe members. The moveable support is moveable to selectively change a relative orientation of the directions of magnetization. One relative orientation primarily directs a flow of magnetic flux between the magnets through the pole shoe members and the magnetic flux remains essentially in a plane containing the magnets and the pole shoe members. A second, different relative orientation primarily directs the flow of magnetic flux from the pole shoe members in a transverse direction away from the plane.

摘要翻译： 示例性的锁定或耦合装置包括各自具有磁化方向的多个磁体。 多个极靴构件位于选定的磁体之间。 可移动支撑件支撑一些磁体和一些极靴构件。 可移动支撑件可移动以选择性地改变磁化方向的相对取向。 一个相对取向主要通过极靴构件引导磁体之间的磁通量，并且磁通量基本上保持在包含磁体和极靴构件的平面内。 第二个不同的相对方向主要是指导从极靴构件的磁通量在远离平面的横向方向上的流动。

公开(公告)号：US20130056306A1

公开(公告)日：2013-03-07

申请号：US13697046

申请日：2010-11-30

申请人： Jinkoo Lee ,  Jung Sam Kim ,  Byeong Sam Yoo ,  Hansoo Shim ,  Guohong Hu ,  Mark Steven Thompson

发明人： Jinkoo Lee ,  Jung Sam Kim ,  Byeong Sam Yoo ,  Hansoo Shim ,  Guohong Hu ,  Mark Steven Thompson

IPC分类号： B66B13/14

CPC分类号： B66B13/24 ,  B66B13/06 ,  B66B13/26 ,  E05F5/003 ,  E05F15/632

摘要： A device for inhibiting the closing of a door that controls entry of an enclosure includes a first magnet disposed on a driven portion of the device and a second magnet disposed on a fixed portion of the enclosure. The first magnet and the second magnet are configured to be in register with each other as the door moves toward a closed position such that if the first magnet and the second magnet are in register with each other, a pole of the first magnet is in close proximity of a pole of the second magnet such that the first magnet and the second magnet react to each other to inhibit motion of the door towards the closed position.

摘要翻译： 用于禁止关闭门的装置，其控制外壳的进入，包括设置在设备的被驱动部分上的第一磁体和设置在外壳的固定部分上的第二磁体。 第一磁体和第二磁体被配置为当门朝着关闭位置移动时彼此对准，使得如果第一磁体和第二磁体彼此对准，则第一磁体的磁极处于闭合状态 靠近第二磁体的磁极，使得第一磁体和第二磁体彼此反应，以阻止门朝向关闭位置的运动。