公开(公告)号：US20090136452A1

公开(公告)日：2009-05-28

申请号：US12065455

申请日：2006-08-30

申请人： Guoying Zhou ,  Bernard Roizman

发明人： Guoying Zhou ,  Bernard Roizman

IPC分类号： A61K35/76 ,  C12N7/00 ,  C12Q1/70 ,  C12N15/87

CPC分类号： C07K16/18 ,  A61K35/00 ,  A61K38/2086 ,  A61K47/642 ,  A61K47/6801 ,  A61K47/69 ,  A61K47/6901 ,  C07K14/5437 ,  C12N15/86 ,  C12N15/8695 ,  C12N2710/16632 ,  C12N2710/16643 ,  C12N2710/16645 ,  C12N2799/028 ,  C12N2810/50 ,  C12N2810/852 ,  C12Q1/705

摘要： The invention relates to engineered Herpes simplex virus (HSV) particles that are targeted to one or more specific binding pair members, such as receptors. Also, recombinant vectors for producing such HSV particles are provided. By reducing the affinity of HSV for its natural receptor(s) and increasing the affinity for a selected receptor, the HSV particles of the invention are useful for targeting cells that express the selected receptor, which itself may be a product of genetic engineering. The ability to selectively target cells render the HSV particles. particularly useful in selectively diagnosing, treating, and imaging cells bearing the selected binding pair member, such as a receptor. The invention also provides for polynucleotide-based therapy to cells bearing the selected binding pair member such as a receptor.

摘要翻译： 本发明涉及靶向一种或多种特异性结合对成员（例如受体）的工程化单纯疱疹病毒（HSV）颗粒。 此外，提供了用于生产这种HSV颗粒的重组载体。 通过降低HSV对其天然受体的亲合力并增加对所选受体的亲和力，本发明的HSV颗粒可用于靶向表达所选受体的细胞，其本身可能是遗传工程的产物。 选择性靶向细胞的能力使HSV颗粒。 特别可用于选择性地诊断，治疗和成像携带所选择的结合对成员例如受体的细胞。 本发明还提供了携带选定结合对成员例如受体的细胞的基于多核苷酸的治疗。

公开(公告)号：US08927251B2

公开(公告)日：2015-01-06

申请号：US12065455

申请日：2006-08-30

申请人： Guoying Zhou ,  Bernard Roizman

发明人： Guoying Zhou ,  Bernard Roizman

IPC分类号： C12N7/01 ,  C12N15/869 ,  A61K39/245 ,  A61K49/00 ,  A61K47/48 ,  A61K38/20 ,  C12Q1/70

CPC分类号： C07K16/18 ,  A61K35/00 ,  A61K38/2086 ,  A61K47/642 ,  A61K47/6801 ,  A61K47/69 ,  A61K47/6901 ,  C07K14/5437 ,  C12N15/86 ,  C12N15/8695 ,  C12N2710/16632 ,  C12N2710/16643 ,  C12N2710/16645 ,  C12N2799/028 ,  C12N2810/50 ,  C12N2810/852 ,  C12Q1/705

摘要： The invention relates to engineered Herpes simplex virus (HSV) particles that are targeted to one or more specific binding pair members, such as receptors. Also, recombinant vectors for producing such HSV particles are provided. By reducing the affinity of HSV for its natural receptor(s) and increasing the affinity for a selected receptor, the HSV particles of the invention are useful for targeting cells that express the selected receptor, which itself may be a product of genetic engineering. The ability to selectively target cells render the HSV particles. particularly useful in selectively diagnosing, treating, and imaging cells bearing the selected binding pair member, such as a receptor. The invention also provides for polynucleotide-based therapy to cells bearing the selected binding pair member such as a receptor.

摘要翻译： 本发明涉及靶向一种或多种特异性结合对成员（例如受体）的工程化单纯疱疹病毒（HSV）颗粒。 此外，提供了用于生产这种HSV颗粒的重组载体。 通过降低HSV对其天然受体的亲合力并增加对选定受体的亲和力，本发明的HSV颗粒可用于靶向表达所选受体的细胞，其本身可能是遗传工程的产物。 选择性靶向细胞的能力使HSV颗粒。 特别可用于选择性地诊断，治疗和成像携带所选择的结合对成员例如受体的细胞。 本发明还提供了携带选定结合对成员例如受体的细胞的基于多核苷酸的治疗。

公开(公告)号：US07550148B2

公开(公告)日：2009-06-23

申请号：US11215636

申请日：2005-08-30

申请人： Guoying Zhou ,  Bernard Roizman

发明人： Guoying Zhou ,  Bernard Roizman

IPC分类号： A01N63/00 ,  A61K48/00 ,  A61K39/245 ,  C12N7/01

CPC分类号： C12N15/86 ,  A61K47/642 ,  A61K47/6901 ,  A61K48/00 ,  C07K2319/74 ,  C12N2710/16643 ,  C12N2710/16645 ,  C12N2810/852

摘要： The invention relates to engineered Herpes simplex virus (HSV) particles that are targeted to one or more specific binding pair members, such as receptors. Also, recombinant vectors for producing such HSV particles are provided. By reducing the affinity of HSV for its natural receptor(s) and increasing the affinity for a selected receptor, the HSV particles of the invention are useful for targeting cells that express the selected receptor, which itself may be a product of genetic engineering. The ability to selectively target cells renders the HSV particles particularly useful in selectively diagnosing, treating, and imaging cells bearing the selected binding pair member, such as a receptor. The invention also provides for polynucleotide-based therapy to cells bearing the selected binding pair member such as a receptor.

摘要翻译： 本发明涉及靶向一种或多种特异性结合对成员（例如受体）的工程化单纯疱疹病毒（HSV）颗粒。 此外，提供了用于生产这种HSV颗粒的重组载体。 通过降低HSV对其天然受体的亲合力并增加对选定受体的亲和力，本发明的HSV颗粒可用于靶向表达所选受体的细胞，其本身可能是遗传工程的产物。 选择性靶向细胞的能力使得HSV颗粒特别可用于选择性地诊断，治疗和成像携带所选择的结合对成员例如受体的细胞。 本发明还提供了携带选定结合对成员例如受体的细胞的基于多核苷酸的治疗。

公开(公告)号：US20070243170A1

公开(公告)日：2007-10-18

申请号：US11677026

申请日：2007-02-20

申请人： Bernard Roizman ,  Guoying Zhou

发明人： Bernard Roizman ,  Guoying Zhou

IPC分类号： A61K35/76 ,  C12N7/00

CPC分类号： A61K48/0008 ,  C07K14/005 ,  C07K14/5437 ,  C07K2319/01 ,  C12N7/00 ,  C12N9/6462 ,  C12N15/86 ,  C12N2710/16622 ,  C12N2710/16643 ,  C12N2810/852 ,  C12N2810/857 ,  C12Y304/21073

摘要： The invention relates to engineered herpes simplex virus (HSV) particles that are targeted to one or more specific binding pair members, such as receptors. Also, recombinant vectors for producing such HSV particles are provided. By reducing the affinity of HSV for its natural receptor(s) and increasing the affinity for a selected receptor, the HSV particles of the invention are useful for targeting cells that express the selected receptor, which itself may be a product of genetic engineering. The ability to selectively target cells renders the HSV particles particularly useful in selectively diagnosing, treating, and imaging cells bearing the selected binding pair member, such as a receptor. The invention also provides for polynucleotide-based therapy to cells bearing the selected binding pair member such as a receptor.

摘要翻译： 本发明涉及靶向一种或多种特异性结合对成员（例如受体）的工程化单纯疱疹病毒（HSV）颗粒。 此外，提供了用于生产这种HSV颗粒的重组载体。 通过降低HSV对其天然受体的亲合力并增加对所选受体的亲和力，本发明的HSV颗粒可用于靶向表达所选受体的细胞，其本身可能是遗传工程的产物。 选择性靶向细胞的能力使得HSV颗粒特别可用于选择性地诊断，治疗和成像携带所选择的结合对成员例如受体的细胞。 本发明还提供了携带选定结合对成员例如受体的细胞的基于多核苷酸的治疗。

公开(公告)号：US20070190027A1

公开(公告)日：2007-08-16

申请号：US11215636

申请日：2005-08-30

申请人： Guoying Zhou ,  Bernard Roizman

发明人： Guoying Zhou ,  Bernard Roizman

IPC分类号： A61K48/00 ,  C12N15/86 ,  C12Q1/70

CPC分类号： C12N15/86 ,  A61K47/642 ,  A61K47/6901 ,  A61K48/00 ,  C07K2319/74 ,  C12N2710/16643 ,  C12N2710/16645 ,  C12N2810/852

摘要： The invention relates to engineered Herpes simplex virus (HSV) particles that are targeted to one or more specific binding pair members, such as receptors. Also, recombinant vectors for producing such HSV particles are provided. By reducing the affinity of HSV for its natural receptor(s) and increasing the affinity for a selected receptor, the HSV particles of the invention are useful for targeting cells that express the selected receptor, which itself may be a product of genetic engineering. The ability to selectively target cells renders the HSV particles particularly useful in selectively diagnosing, treating, and imaging cells bearing the selected binding pair member, such as a receptor. The invention also provides for polynucleotide-based therapy to cells bearing the selected binding pair member such as a receptor.

摘要翻译： 本发明涉及靶向一种或多种特异性结合对成员（例如受体）的工程化单纯疱疹病毒（HSV）颗粒。 此外，提供了用于生产这种HSV颗粒的重组载体。 通过降低HSV对其天然受体的亲合力并增加对所选受体的亲和力，本发明的HSV颗粒可用于靶向表达所选受体的细胞，其本身可能是遗传工程的产物。 选择性靶向细胞的能力使得HSV颗粒特别可用于选择性地诊断，治疗和成像携带所选择的结合对成员（例如受体）的细胞。 本发明还提供了携带选定结合对成员例如受体的细胞的基于多核苷酸的治疗。