公开(公告)号：US20080045580A1

公开(公告)日：2008-02-21

申请号：US11577031

申请日：2005-10-11

申请人： Gurram Madhavan ,  Javed Iqbal ,  Debnath Bhuniya ,  Saibal Das ,  Sudhir Sharma ,  Ranjan Chakrabarti

发明人： Gurram Madhavan ,  Javed Iqbal ,  Debnath Bhuniya ,  Saibal Das ,  Sudhir Sharma ,  Ranjan Chakrabarti

IPC分类号： A61K31/42 ,  A61P29/00 ,  A61P3/10 ,  A61P9/00 ,  A61P9/12 ,  C07D261/08 ,  C07D413/12

CPC分类号： C07D275/02 ,  C07D261/08 ,  C07D413/12

摘要： The present invention relates to novel isoxazole compounds of formula (I) having (PPAR) agonist activity, pharmaceutical compositions containing such compounds and methods for their use.

摘要翻译： 本发明涉及具有（PPAR）激动剂活性的式（I）的异恶唑化合物，含有这些化合物的药物组合物及其用途。

公开(公告)号：US20050113368A1

公开(公告)日：2005-05-26

申请号：US10492454

申请日：2002-10-15

申请人： Debnath Bhuniya ,  Saibal Das ,  Gurram Madhavan ,  Javed Iqbal ,  Ranjan Chakrabarti

发明人： Debnath Bhuniya ,  Saibal Das ,  Gurram Madhavan ,  Javed Iqbal ,  Ranjan Chakrabarti

IPC分类号： A61K9/08 ,  A61K9/10 ,  A61K9/14 ,  A61K9/20 ,  A61K9/48 ,  A61K31/538 ,  A61K31/5415 ,  A61P1/04 ,  A61P1/14 ,  A61P1/18 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P9/10 ,  A61P9/12 ,  A61P13/12 ,  A61P15/00 ,  A61P17/06 ,  A61P19/10 ,  A61P21/04 ,  A61P25/28 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07B61/00 ,  C07C227/04 ,  C07C227/18 ,  C07C229/34 ,  C07C229/42 ,  C07D265/36 ,  C07D279/16

CPC分类号： C07C229/42 ,  C07C229/34 ,  C07D265/36 ,  C07D279/16

摘要： The present invention relates to novel antidiabetic, hypolipidemic, antiobesity and hypocholesterolemic compounds of formula (I) their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them, to a process for preparing such compounds. More particularly, the present invention relates to novel alkyl carboxylic acids of the general, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them, to a process for preparing such compounds. The present invention also relates to processes for the preparation of the compounds of formula (I), novel intermediates, processes for their preparation, their use in the preparation of the above said compounds and their use as antidiabetic, hypolipidemic, antiobesity and hypocholesterolemic compounds.

摘要翻译： 本发明涉及式（I）衍生物，其类似物，其互变异构形式，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂合物和含有它们的药学上可接受的组合物的新型抗糖尿病，降血脂，抗胆固醇和低胆固醇血症化合物 涉及制备这种化合物的方法。 更具体地说，本发明涉及通用的衍生物，其衍生物，它们的类似物，它们的互变异构形式，它们的立体异构体，它们的多晶型物，其药学上可接受的盐，其药学上可接受的溶剂化物和含有它们的药学上可接受的组合物的新型烷基羧酸， 制备此类化合物的方法。 本发明还涉及式（I）化合物的制备方法，新型中间体，其制备方法，它们在制备上述化合物中的用途及其作为抗糖尿病，降血脂症，抗肥胖症和低胆固醇血症化合物的用途。