公开(公告)号：US08765799B2

公开(公告)日：2014-07-01

申请号：US13056751

申请日：2009-07-16

申请人： Cosima Dufour-Schroif ,  Joachim Wink ,  Martin Gerlitz ,  Hélène Olivan ,  Michael Kurz

发明人： Cosima Dufour-Schroif ,  Joachim Wink ,  Martin Gerlitz ,  Hélène Olivan ,  Michael Kurz

IPC分类号： A61K31/407 ,  C07D491/107 ,  C07D498/10

CPC分类号： C07D498/10 ,  C07D491/107

摘要： The invention relates to streptospirole derivatives of the general formula (I), wherein R1, R2, R3, X1, X2, Y1 and Y2 are as defined herein, a process for the preparation of said compounds by fermenting the microorganism Streptomyces sp. ST 108140 (DSM 19369) and optionally derivatizing the compounds produced by said microorganism, a pharmaceutical composition comprising at least one compound of the formula (I), and the use of a compound of the formula (I) for the preparation of a medicament for the treatment and/or prophylaxis of bacterial infections.

摘要翻译： 本发明涉及通式（I）的链霉菌素衍生物，其中R1，R2，R3，X1，X2，Y1和Y2如本文所定义，通过发酵微生物Streptomyces sp。 ST108404（DSM19369），并任选地衍生由所述微生物产生的化合物，包含至少一种式（I）化合物的药物组合物和式（I）化合物在制备药物中的应用 治疗和/或预防细菌感染。