公开(公告)号：US20220241555A1

公开(公告)日：2022-08-04

申请号：US17620705

申请日：2020-06-17

Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. ,  Hadasit Medical Research Service and Development Ltd.

Inventor： Mohammad GHOSHEH ,  Abed KHALAILEH ,  Yevgeni PLOTKIN ,  Yaakov NAHMIAS ,  Yoav MINTZ ,  Elchanan FRIED

IPC: A61M25/00 ,  A61B1/00 ,  A61B5/0538 ,  A61B5/00 ,  A61B5/06 ,  A61M25/01 ,  A61M25/06

Abstract: The present disclosure provides endoscopic retrograde cholangiopancreatography (ERCP) catheter systems having multiple ports and sensors configured to determine the location of the catheter's and/or guidewire's distal end as well as optional one or more magnetic bending aids, configured to aim a guidewire to the desired duct location. Further provided is a guidewire having a magnetic end and optional sensing elements. Also provided are methods of using the catheters and/or guidewires in ERCP procedures.

公开(公告)号：US20160017019A1

公开(公告)日：2016-01-21

申请号：US14773349

申请日：2014-03-06

Applicant: PROTALIX LTD. ,  HADASIT MEDICAL RESEARCH SERVICE AND DEVELOPMENT LTD.

Inventor： Yaron ILAN ,  Yoseph SHAALTIEL ,  Uri HANANIA ,  Tali KIZHNER ,  Tami ARIEL ,  Svetlana GINGIS-VELITSKI

IPC: C07K14/705 ,  A61K9/00 ,  A61K36/81 ,  C12N15/82 ,  C07K16/24

CPC classification number: C07K14/70578 ,  A61K9/0053 ,  A61K36/81 ,  A61K38/00 ,  C07K14/525 ,  C07K16/241 ,  C07K2317/14 ,  C07K2317/76 ,  C07K2319/30 ,  C07K2319/74 ,  C12N15/8257 ,  C12N15/8258

Abstract: A method of treating a TNF Alpha associated medical condition selected from the group consisting of obesity, metabolic syndrome, diabetes and a liver disease or disorder is provided. The method comprising enterally administering to a subject in need thereof a therapeutically effective amount of plant cells expressing a TNF Alpha polypeptide inhibitor, thereby treating the TNF Alpha associated medical condition.

Abstract translation: 提供了一种治疗选自肥胖症，代谢综合征，糖尿病和肝病或病症的TNFα相关医学病症的方法。 该方法包括向有需要的受试者肠道施用治疗有效量的表达TNFα多肽抑制剂的植物细胞，从而治疗TNFα相关的医学病症。