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公开(公告)号：US20240208952A1
公开(公告)日：2024-06-27
申请号：US18283465
申请日：2022-03-17
发明人： Wenqiang ZHAI , Zhimin ZHANG , Liubin GUO , Dongzhou LIU , Hao PAN
IPC分类号： C07D409/14 , A61K31/4375 , A61K31/4545 , A61K31/506 , C07D491/147
CPC分类号： C07D409/14 , A61K31/4375 , A61K31/4545 , A61K31/506 , C07D491/147
摘要： Provided are a series of thiophene GLP-I receptor agonist com-pounds, a preparation method therefor and the pharmaceutical use thereof. The compounds can be used for preparing drugs for treating or preventing GLP-1-mediated diseases and related diseases.
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公开(公告)号：US20240360110A1
公开(公告)日：2024-10-31
申请号：US18613714
申请日：2024-03-22
发明人： Wenqiang Zhai , Zhimin Zhang , Zhe Wang , Hao Pan , Liubin Guo , Qian Wang
IPC分类号： C07D405/14
CPC分类号： C07D405/14
摘要： Provided are a GLP-1 receptor agonist compound and a composition and use thereof. The compound can be used for treating or preventing GLP-1 receptor-mediated diseases or disorders and related diseases or disorders.
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3.发明公开公开(公告)号：US20240025864A1
公开(公告)日：2024-01-25
申请号：US18036108
申请日：2021-09-11
发明人： Junho ZHENG , Xuming HONG , Duqian ZHANG , Thomas E. ROGERS , Elena CACCHILLO
IPC分类号： C07D241/26 , C07D487/14
CPC分类号： C07D241/26 , C07D487/14
摘要： A method for preparing 3,6-diaminopyrazine-2,5-dicarboxylic acid and a synthetic intermediate thereof. The method comprises the step of preparing pyrimido[4,5-g]pteridine-2,4,7,9(1H,3H,6H,8H)-tetraone or a disalt (pteridine) thereof from 5-aminouracil or a single salt thereof.
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公开(公告)号：US20230138901A1
公开(公告)日：2023-05-04
申请号：US17788415
申请日：2020-12-24
发明人： Zhixiang PAN , Haiying HE , Zhigan JIANG , Jianhua XIA , Lei ZHANG , Chen ZHANG , Jian LI , Shuhui CHEN
IPC分类号： C07D495/04 , C07D403/04 , C07D513/04 , A61P3/08
摘要： A compound having a KHK inhibitory effect, or pharmaceutically acceptable salts thereof, and use thereof in the preparation of a medicament for treating a disease associated with KHK kinase abnormal expression. Provided is a compound as represented by formula (III) or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20240325549A1
公开(公告)日：2024-10-03
申请号：US18602255
申请日：2024-03-12
发明人： Nan ZHANG , Chunhua Jiang , Dongzhou Liu , Li Teng , Jiale Shen
IPC分类号： A61K47/64 , A61P3/04 , A61P3/10 , C07K14/605
CPC分类号： A61K47/64 , A61P3/04 , A61P3/10 , C07K14/605
摘要： The present invention relates to long-acting GLP-1/GIP dual agonist compounds having a dual agonistic effect on glucagon-like peptide-1 (GLP-1) receptor and human glucose-dependent insulinotropic polypeptide (GIP) receptor. The present invention also relates to the use of said compounds in the manufacture of medicaments for treating Type II diabetes mellitus.
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公开(公告)号：US20240043888A1
公开(公告)日：2024-02-08
申请号：US18264400
申请日：2021-12-24
发明人： Zhaobing CHENG , Guanghui KOU , Yiming XU , Weijie HU , Yuchen ZHANG
CPC分类号： C12P17/162 , C12N1/205 , C12N2500/34 , C12N2500/42 , C12N2500/35 , C12N2500/76 , C12N2500/16 , C12N2500/74 , C12N2500/22 , C12R2001/38
摘要： A fermentation method for mupirocin, the method comprising performing shake flask seed culture, seed tank culture, fermentation culture, feed culture. The fermentation method is not only suitable for industrial mass production, but also improves the fermentation potency of mupirocin, which can be stably maintained to be 8000 ug/ml or above.
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公开(公告)号：US20230312540A1
公开(公告)日：2023-10-05
申请号：US18022806
申请日：2021-08-11
发明人： Zhaobing CHENG , Guanghui KOU , Yiming XU , Kai ZHANG , Yuchen ZHANG
IPC分类号： C07D407/06 , B01D11/04 , B01D15/08
CPC分类号： C07D407/06 , B01D11/0492 , B01D15/08
摘要： A method for extracting mupirocin. The main steps thereof comprise: resin adsorption, desorption and concentration, multi-step extraction, and dehydration and decoloration, wherein the multi-step extraction comprises at least one ester solvent extraction and at least one alkaline water extraction. The method is suitable for industrialization, the extraction recovery rate of mupirocin is 80% or more, and the purity of the mupirocin is 80% or more.
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公开(公告)号：US20240239863A1
公开(公告)日：2024-07-18
申请号：US18586899
申请日：2024-02-26
发明人： Honghao LI , Wenchen LI , Haisong XIE , Yingchi ZHAO , Hongmei XU
IPC分类号： C07K14/645 , A61K9/00 , A61K38/00 , A61K47/54 , A61P3/10
CPC分类号： C07K14/645 , A61K9/0019 , A61K47/542 , A61P3/10 , A61K38/00
摘要： The present invention is in the field of biomedical technology, and discloses a peptide compound having agonistic activity at glucose-dependent insulinotropic polypeptide (GIP) receptors, and use the peptide compound. The compound provided by the present invention has an improved agonistic activity at GIP receptors and selectively activate the GIP receptors, and may be used in the manufacture of medicaments associated with type 2 diabetes and weight loss.
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公开(公告)号：US11981666B2
公开(公告)日：2024-05-14
申请号：US18367517
申请日：2023-09-13
发明人： Wenqiang Zhai , Zhimin Zhang , Zhe Wang , Hao Pan , Liubin Guo , Qian Wang
IPC分类号： C07D405/14
CPC分类号： C07D405/14
摘要： Provided are a GLP-1 receptor agonist compound and a composition and use thereof. The compound can be used for treating or preventing GLP-1 receptor-mediated diseases or disorders and related diseases or disorders.
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公开(公告)号：US20240116906A1
公开(公告)日：2024-04-11
申请号：US18367517
申请日：2023-09-13
发明人： Wenqiang ZHAI , Zhimin ZHANG , Zhe WANG , Hao PAN , Liubin GUO , Qian WANG
IPC分类号： C07D405/14
CPC分类号： C07D405/14
摘要： Provided are a GLP-1 receptor agonist compound and a composition and use thereof. The compound can be used for treating or preventing GLP-1 receptor-mediated diseases or disorders and related diseases or disorders.
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