Anti-arrhythmic 5-endo-substituted oxy-N-(aminoloweralkyl)bicycle [2.2.2.]o
c
    4.
    发明授权
    Anti-arrhythmic 5-endo-substituted oxy-N-(aminoloweralkyl)bicycle [2.2.2.]o c 失效
    抗心律不齐的5-端取代的氧-N-(氨基低级烷基)自行车{8 2.2.2。{9辛烷-2,3-二 - 内 - 羧酸酰亚胺

    公开(公告)号:US3980667A

    公开(公告)日:1976-09-14

    申请号:US555651

    申请日:1975-03-05

    CPC分类号: C07D307/77 C07D209/76

    摘要: Series of 5-endo-benzoyloxy-N-[amino(lower)-alkyl]bicyclo[2.2.2]octane-2,3-di-endo-carboxylic acid imides, 5-endo-(3-indolecarbonyloxy)-N-[amino-(lower)alkyl]bicyclo[2.2.2]octane-2,3-di-endo-carboxylic acid imides, 5-endo-n-substituted-carbamoyloxy-N-[amino(lower)alkyl]bicyclo[2.2.2]octane-2,3-di-endo-carboxylic acid imides and 5-endo-(1-naphthoyloxy)-N-[amino(lower)alkyl]bicyclo[2.2.2]octane-2,3-di-endo-carboxylic acid imides have been found to possess unique prophylactic and therapeutic activity as anti-arrhythmia agents. An example of such a compound possessing activity is 5-endo-(3-indolecarbonyloxy)-N-(3-dimethylaminopropyl)bicyclo[2.2.2]octane-2,3-di-endo-carboxylic acid imide hydrochloride of the formula ##SPC1##

    摘要翻译: 5-内 - 苯甲酰氧基-N- [氨基(低级) - 烷基]双环[2.2.2]辛烷-2,3-二 - 羧酸酰亚胺系列,5-内 - (3-吲哚羰基氧基)-N - [氨基 - (低级)烷基]双环[2.2.2]辛-2-基-2,3-二 - 内 - 羧酸酰亚胺,5-内 - 取代 - 氨基甲酰氧基-N- [氨基(低级)烷基]双环 [2.2.2]烷-2,3-二 - 内 - 羧酸酰亚胺和5-内 - (1-萘氧基)-N- [氨基(低级)烷基]双环[2.2.2]辛烷-2,3 已经发现二 - 内 - 羧酸酰亚胺作为抗心律失常药具有独特的预防和治疗活性。 这种具有活性的化合物的实例是式(I)的5-内 - (3-吲哚羰基氧基)-N-(3-二甲基氨基丙基)双环[2.2.2]咔啉-2,3-二 - 内 - 羧酸酰亚胺盐酸盐