公开(公告)号：US11827719B2

公开(公告)日：2023-11-28

申请号：US16841527

申请日：2020-04-06

Applicant: HUBIT GENOMIX, INC. ,  NATIONAL CENTER FOR CHILD HEALTH AND DEVELOPMENT ,  Yutaka Ishizaka

Inventor： Hirohisa Saito ,  Kenji Matsumoto ,  Hideaki Morita ,  Go Ichien ,  Yasuhiko Koezuka ,  Kimishige Ishizaka

IPC: A61P37/08 ,  C07K16/42

CPC classification number: C07K16/4291 ,  A61P37/08

Abstract: The disclosure provides a pharmaceutical composition containing an anti-IgE antibody that suppresses the production of allergen-specific IgE antibodies and methods of use thereof.

公开(公告)号：US20200231705A1

公开(公告)日：2020-07-23

申请号：US16841527

申请日：2020-04-06

Applicant: Yutaka Ishizaka ,  HUBIT GENOMIX, INC. ,  NATIONAL CENTER FOR CHILD HEALTH AND DEVELOPMENT

Inventor： Hirohisa Saito ,  Kenji Matsumoto ,  Hideaki Morita ,  Go Ichien ,  Yasuhiko Koezuka ,  Kimishige Ishizaka

IPC: C07K16/42 ,  A61P37/08

Abstract: The disclosure provides a pharmaceutical composition containing an anti-IgE antibody that suppresses the production of allergen-specific IgE antibodies and methods of use thereof

公开(公告)号：US20240103014A1

公开(公告)日：2024-03-28

申请号：US17950632

申请日：2022-09-22

Applicant: HuBit genomix, Inc. ,  Fuso Pharmaceutical Industries, Ltd.

Inventor： Toshio Doi ,  Tatsuya Tominaga ,  Go Ichien ,  Keiichi Yamamoto

IPC: G01N33/68

CPC classification number: G01N33/6875 ,  G01N33/6854 ,  G01N2800/347

Abstract: The present disclosure provides a method of detecting IgG4 and Smad1 in a biological sample from a subject with onset or a risk of onset of diabetic nephropathy.

公开(公告)号：US20240101711A1

公开(公告)日：2024-03-28

申请号：US18516082

申请日：2023-11-21

Applicant: HUBIT GENOMIX, INC. ,  NATIONAL CENTER FOR CHILD HEALTH AND DEVELOPMENT

Inventor： Hirohisa SAITO ,  Kenji MATSUMOTO ,  Hideaki MORITA ,  Go ICHIEN ,  Yasuhiko KOEZUKA ,  Kimishige ISHIZAKA

IPC: C07K16/42 ,  A61P37/08

CPC classification number: C07K16/4291 ,  A61P37/08

Abstract: The disclosure provides a pharmaceutical composition containing an anti-IgE antibody that suppresses the production of allergen-specific IgE antibodies and methods of use thereof.

公开(公告)号：US20210285963A1

公开(公告)日：2021-09-16

申请号：US16338729

申请日：2017-09-26

Applicant: HuBit genomix, Inc. ,  Fuso Pharmaceutical Industries, Ltd.

Inventor： Toshio Doi ,  Tatsuya Tominaga ,  Go Ichien ,  Keiichi Yamamoto

IPC: G01N33/68 ,  G01N33/577

Abstract: The present invention provides a test method which enables specific diagnosis of early-stage pathology of diabetic nephropathy. There is provided a method of detecting onset or a risk of onset of diabetic nephropathy, comprising measuring IgG4 in a biological sample derived from a subject. This method may further comprise measuring Smad1 in the biological sample derived from the subject. Preferably, both IgG4 and Smad1 are measured.

公开(公告)号：US20190314339A1

公开(公告)日：2019-10-17

申请号：US16372571

申请日：2019-04-02

Applicant: HuBit Genomix, Inc. ,  Fuso Pharmaceutical Industries, Ltd.

Inventor： Toshio Doi ,  Tatsuya Tominaga ,  Yui Fujita

IPC: A61K31/415 ,  A61P13/12 ,  A61K9/00 ,  A61K31/167 ,  A61K31/192

Abstract: The present invention provides a drug capable of preventing or treating diabetic nephropathy.The present invention relates to a prophylactic and/or therapeutic drug for diabetic nephropathy, comprising a RARγ agonist as an active ingredient. The present invention also provides a prophylactic and/or therapeutic drug for renal anemia; a drug inhibiting the expression of type IV collagen in mesangial cells; a drug inhibiting the expression of BMP4 in mesangial cells; and a drug inhibiting fibrosis in the renal tubulointerstitium.

公开(公告)号：US20250163185A1

公开(公告)日：2025-05-22

申请号：US18516127

申请日：2023-11-21

Applicant: HUBIT GENOMIX, INC. ,  NATIONAL CENTER FOR CHILD HEALTH AND DEVELOPMENT

Inventor： Hirohisa SAITO ,  Kenji MATSUMOTO ,  Hideaki MORITA ,  Go ICHIEN ,  Yasuhiko KOEZUKA ,  Kimishige ISHIZAKA

IPC: C07K16/42 ,  A61P37/08

Abstract: The disclosure provides a pharmaceutical composition containing an anti-IgE antibody that suppresses the production of allergen-specific IgE antibodies and methods of use thereof

公开(公告)号：US10828279B2

公开(公告)日：2020-11-10

申请号：US16372571

申请日：2019-04-02

Applicant: HuBit genomix, Inc. ,  Fuso Pharmaceutical Industries, Ltd.

Inventor： Toshio Doi ,  Tatsuya Tominaga ,  Yui Fujita

IPC: A61K31/415 ,  A61P13/12 ,  A61K31/192 ,  A61K31/167 ,  A61K9/00

Abstract: The present invention provides a drug capable of preventing or treating diabetic nephropathy.The present invention relates to a prophylactic and/or therapeutic drug for diabetic nephropathy, comprising a RARγ agonist as an active ingredient. The present invention also provides a prophylactic and/or therapeutic drug for renal anemia; a drug inhibiting the expression of type IV collagen in mesangial cells; a drug inhibiting the expression of BMP4 in mesangial cells; and a drug inhibiting fibrosis in the renal tubulointerstitium.

公开(公告)号：US20160333412A1

公开(公告)日：2016-11-17

申请号：US15146515

申请日：2016-05-04

Applicant: Toshio Doi ,  HUBIT GENOMIX INC.

Inventor： Toshio Doi ,  Hideharu ABE

IPC: C12Q1/68 ,  C07K16/28 ,  G01N33/68

CPC classification number: C12Q1/6883 ,  A61K45/06 ,  C07K16/2863 ,  C07K2317/76 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/6893 ,  G01N2333/4703 ,  G01N2333/4706 ,  G01N2333/51 ,  G01N2333/71

Abstract: A method of detecting proliferative diseases causing sclerosis, comprising measuring the expression of at least one substance selected from the group consisting of STAT3, phosphorylated STAT3, Smad1, phosphorylated Smad1, activin receptor-like kinase 1, activin receptor-like kinase 3 and bone morphogenetic proteins in a biological sample. A kit therefor. A prophylactic and/or therapeutic agent for proliferative diseases causing sclerosis, comprising as an active ingredient a substance having an inhibitory effect on the expression of at least one substance selected from the group consisting of STAT3, phosphorylated STAT3, Smad1 and phosphorylated Smad1. A method of identifying substances effective in preventing and/or treating proliferative diseases causing sclerosis, comprising judging whether or not a test substance inhibits the expression of at least one substance selected from the group consisting of STAT3, phosphorylated STAT3, Smad1 and phosphorylated Smad1. A kit therefor.

Abstract translation: 一种检测引起硬化的增殖性疾病的方法，包括测量选自STAT3，磷酸化STAT3，Smad1，磷酸化Smad1，激活素受体样激酶1，激活素受体样激酶3和骨形态发生的至少一种物质的表达 生物样品中的蛋白质。 一个套件。 一种引起硬化的增殖性疾病的预防和/或治疗剂，其包含作为活性成分的对STAT3，磷酸化STAT3，Smad1和磷酸化Smad1中选择的至少一种物质的表达具有抑制作用的物质。 鉴定有效预防和/或治疗引起硬化的增殖性疾病的物质的方法，包括判断测试物质是否抑制至少一种选自STAT3，磷酸化STAT3，Smad1和磷酸化Smad1的物质的表达。 一个套件。