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公开(公告)号：US11827719B2
公开(公告)日：2023-11-28
申请号：US16841527
申请日：2020-04-06
发明人： Hirohisa Saito , Kenji Matsumoto , Hideaki Morita , Go Ichien , Yasuhiko Koezuka , Kimishige Ishizaka
CPC分类号： C07K16/4291 , A61P37/08
摘要： The disclosure provides a pharmaceutical composition containing an anti-IgE antibody that suppresses the production of allergen-specific IgE antibodies and methods of use thereof.
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2.发明申请公开(公告)号：US20200231705A1
公开(公告)日：2020-07-23
申请号：US16841527
申请日：2020-04-06
发明人： Hirohisa Saito , Kenji Matsumoto , Hideaki Morita , Go Ichien , Yasuhiko Koezuka , Kimishige Ishizaka
摘要： The disclosure provides a pharmaceutical composition containing an anti-IgE antibody that suppresses the production of allergen-specific IgE antibodies and methods of use thereof
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3.发明申请公开(公告)号：US20160289663A1
公开(公告)日：2016-10-06
申请号：US15037907
申请日：2014-11-17
IPC分类号： C12N9/96 , C12N9/12 , G01N33/574 , A61K31/506 , C07K14/47
CPC分类号： C12N9/96 , A61K31/404 , A61K31/5025 , A61K31/506 , A61K45/06 , C07K14/4702 , C07K14/71 , C07K2319/00 , C12N9/12 , C12Y207/10001 , G01N33/502 , G01N33/57484 , G01N2500/00 , G01N2500/10 , A61K2300/00
摘要： To identify a mutation that can serve as an indicator for predicting the effectiveness of drug treatment in cancers such as leukemia; to provide a means for detecting said mutation; and to provide a means for identifying, based on said mutation, patients with cancer or subjects with a risk of cancer, in whom a drug targeting a gene having said mutation or a protein encoded by said gene shows a therapeutic effect.A method for detecting a gene fusion serving as a responsible mutation (driver mutation) for cancer, the method comprising the step of detecting an ATF7IP-PDGFRB fusion polynucleotide or a polypeptide encoded thereby, in an isolated sample from a subject.
摘要翻译： 一种用于检测用于癌症的负责突变（驱动突变）的基因融合体的方法，该方法包括在受试者的分离样品中检测ATF7IP-PDGFRB融合多核苷酸或由其编码的多肽的步骤。
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