公开(公告)号：US20120178684A1

公开(公告)日：2012-07-12

申请号：US13004560

申请日：2011-01-11

Applicant: SUNG-TSUEN LIU ,  SUNG-CHING CHEN ,  HUI-CHUN LAI ,  KEHSIN CHIEN

Inventor： SUNG-TSUEN LIU ,  SUNG-CHING CHEN ,  HUI-CHUN LAI ,  KEHSIN CHIEN

IPC: A61K38/18 ,  A61K47/02 ,  A61P19/08 ,  C04B12/02

CPC classification number: A61L24/0084 ,  A61L24/0015 ,  A61L24/0042 ,  A61L24/0089

Abstract: The present invention discloses a surgical cement and a manufacturing method thereof. The surgical cement comprises a cementing component selected form the group of a basic calcium phosphate consisting of tetracalcium phosphate, alpha-tricalcium phosphate, decomposed hydroxyapatite, or a combination thereof; a setting reagent selected form the group of an acidic calcium citrate consisting of monocalcium citrate, dicalcium citrate, or a combination thereof; and water; wherein a weight ratio of the cementing component and the setting reagent ranges from about 1:1 to about 8:1. The surgical cement is bioresorbable and bioactive and is useful in orthopedic, maxillofacial and dental applications. In addition, the surgical cement of this invention has a good flow character and a relatively short setting time.

Abstract translation: 本发明公开了一种外科手术水泥及其制造方法。 手术水泥包括选自由磷酸四钙，磷酸α-磷酸三钙，分解的羟基磷灰石或其组合组成的碱性磷酸钙组的粘合组分; 选自柠檬酸一柠檬酸钙，柠檬酸二钙或其组合的酸性柠檬酸钙组的凝固试剂; 和水; 其中所述粘合组分和凝固剂的重量比范围为约1:1至约8:1。 手术水泥是生物可再吸收和生物活性的，可用于矫形，颌面和牙科应用。 此外，本发明的外科手术水泥具有良好的流动特性和较短的凝固时间。

公开(公告)号：US08962037B2

公开(公告)日：2015-02-24

申请号：US13023318

申请日：2011-02-08

Applicant: Sung-Tsuen Liu ,  Sung-Ching Chen ,  Hui-Chun Lai ,  Wan-Ting Huang

Inventor： Sung-Tsuen Liu ,  Sung-Ching Chen ,  Hui-Chun Lai ,  Wan-Ting Huang

IPC: A01N59/24 ,  A61K6/083 ,  C01B15/16 ,  C04B35/447 ,  A61L27/12 ,  A61L27/56 ,  C01B25/32 ,  C04B38/04 ,  C04B111/00

CPC classification number: C04B35/447 ,  A61L27/12 ,  A61L27/56 ,  A61L2430/02 ,  A61L2430/12 ,  C01B25/32 ,  C04B38/04 ,  C04B2111/00836 ,  C04B2235/3212 ,  C04B2235/5427 ,  C04B2235/606

Abstract: The present invention discloses a method of manufacturing pure dicalcium phosphate ceramics or dicalcium phosphate/hydroxyapaite (HA) biphasic ceramics for medical applications in hard tissue areas to be used as implant materials. These ceramic implant materials are in granular form or in block form, and are prepared by using an acidic phosphate compound, a basic calcium phosphate compound comprising HA, and water. The dicalcium phosphate ceramic comprises either dicalcium phosphate dihydrate (CaHPO4.2H2O, DCPD) or dicalcium anhydrous (CaHPO4, DCPA). Wherein, when the acidic phosphate compound is provided in an amount stoichiometrically equal to or in excess relative to the basic calcium phosphate compound, a reaction product is the DCPD or DCPA ceramic; when the acidic phosphate compound is provided in the amount stoichiometrically less than the basic calcium phosphate compound, the reaction product is the DCPD/HA or DCPA/HA biphasic ceramic.

Abstract translation: 本发明公开了一种制造纯磷酸二钙陶瓷或磷酸二钙/羟基磷灰石（HA）双相陶瓷的方法，用于在硬组织区域中用作植入材料的医疗应用。 这些陶瓷植入材料为颗粒形式或块状，并且通过使用酸性磷酸盐化合物，包含HA的碱式磷酸钙化合物和水来制备。 磷酸二钙陶瓷包括磷酸二钙二水合物（CaHPO 4·2H 2 O，DCPD）或无水二钙（CaHPO 4，DCPA）。 其中，当酸性磷酸盐化合物以相对于碱式磷酸钙化合物的化学计量等于或过量的量提供时，反应产物是DCPD或DCPA陶瓷; 当酸化磷酸盐化合物以化学计量比碱性磷酸钙化合物的量提供时，反应产物是DCPD / HA或DCPA / HA双相陶瓷。

公开(公告)号：US20120201870A1

公开(公告)日：2012-08-09

申请号：US13023318

申请日：2011-02-08

Applicant: SUNG-TSUEN LIU ,  SUNG-CHING CHEN ,  HUI-CHUN LAI ,  WAN-TING HUANG

Inventor： SUNG-TSUEN LIU ,  SUNG-CHING CHEN ,  HUI-CHUN LAI ,  WAN-TING HUANG

IPC: A61K33/42 ,  A61K9/00 ,  A61P19/00 ,  C01B25/32

CPC classification number: C04B35/447 ,  A61L27/12 ,  A61L27/56 ,  A61L2430/02 ,  A61L2430/12 ,  C01B25/32 ,  C04B38/04 ,  C04B2111/00836 ,  C04B2235/3212 ,  C04B2235/5427 ,  C04B2235/606

Abstract: The present invention discloses a method of manufacturing pure dicalcium phosphate ceramics or dicalcium phosphate/hydroxyapaite (HA) biphasic ceramics for medical applications in hard tissue areas to be used as implant materials. These ceramic implant materials are in granular form or in block form, and are prepared by using an acidic phosphate compound, a basic calcium phosphate compound comprising HA, and water. The dicalcium phosphate ceramic comprises either dicalcium phosphate dihydrate (CaHPO4.2H2O, DCPD) or dicalcium anhydrous (CaHPO4, DCPA). Wherein, when the acidic phosphate compound is provided in an amount stoichiometrically equal to or in excess relative to the basic calcium phosphate compound, a reaction product is the DCPD or DCPA ceramic; when the acidic phosphate compound is provided in the amount stoichiometrically less than the basic calcium phosphate compound, the reaction product is the DCPD/HA or DCPA/HA biphasic ceramic.

Abstract translation: 本发明公开了一种制造纯磷酸二钙陶瓷或磷酸二钙/羟基磷灰石（HA）双相陶瓷的方法，用于在硬组织区域中用作植入材料的医疗应用。 这些陶瓷植入材料为颗粒形式或块状，并且通过使用酸性磷酸盐化合物，包含HA的碱式磷酸钙化合物和水来制备。 磷酸二钙陶瓷包括磷酸二钙二水合物（CaHPO 4·2H 2 O，DCPD）或无水二钙（CaHPO 4，DCPA）。 其中，当酸性磷酸盐化合物以相对于碱式磷酸钙化合物的化学计量等于或过量的量提供时，反应产物是DCPD或DCPA陶瓷; 当酸化磷酸盐化合物以化学计量比碱性磷酸钙化合物的量提供时，反应产物是DCPD / HA或DCPA / HA双相陶瓷。

公开(公告)号：US08414930B2

公开(公告)日：2013-04-09

申请号：US13004560

申请日：2011-01-11

Applicant: Sung-Tsuen Liu ,  Sung-Ching Chen ,  Hui-Chun Lai ,  Kehsin Chien

Inventor： Sung-Tsuen Liu ,  Sung-Ching Chen ,  Hui-Chun Lai ,  Kehsin Chien

IPC: C04B35/00

CPC classification number: A61L24/0084 ,  A61L24/0015 ,  A61L24/0042 ,  A61L24/0089

Abstract: The present invention discloses a surgical cement and a manufacturing method thereof. The surgical cement comprises a cementing component selected form the group of a basic calcium phosphate consisting of tetracalcium phosphate, alpha-tricalcium phosphate, decomposed hydroxyapatite, or a combination thereof; a setting reagent selected form the group of an acidic calcium citrate consisting of monocalcium citrate, dicalcium citrate, or a combination thereof; and water; wherein a weight ratio of the cementing component and the setting reagent ranges from about 1:1 to about 8:1. The surgical cement is bioresorbable and bioactive and is useful in orthopedic, maxillofacial and dental applications. In addition, the surgical cement of this invention has a good flow character and a relatively short setting time.

Abstract translation: 本发明公开了一种外科手术水泥及其制造方法。 手术水泥包括选自由磷酸四钙，磷酸α-磷酸三钙，分解羟基磷灰石或其组合组成的碱性磷酸钙组的粘合组分; 选自柠檬酸一柠檬酸钙，柠檬酸二钙或其组合的酸性柠檬酸钙组的凝固试剂; 和水; 其中所述粘合组分和凝固剂的重量比范围为约1:1至约8:1。 手术水泥是生物可再吸收和生物活性的，可用于矫形，颌面和牙科应用。 此外，本发明的外科手术水泥具有良好的流动特性和较短的凝固时间。