公开(公告)号：US20240358417A1

公开(公告)日：2024-10-31

申请号：US18770157

申请日：2024-07-11

Applicant: MediCarbone, Inc.

Inventor： Ravichandran Kollarigowda ,  Krishna Kolan ,  Neda Saadatmanesh ,  Hamid Saadatmanesh ,  Abiraman Srinivasan

IPC: A61B17/72 ,  A61B17/56 ,  A61B17/68 ,  A61B17/88 ,  A61L15/12 ,  A61L15/14 ,  A61L27/12 ,  A61L27/16

CPC classification number: A61B17/7258 ,  A61B17/68 ,  A61B17/8805 ,  A61B17/8836 ,  A61B17/8858 ,  A61L15/125 ,  A61L15/14 ,  A61L27/12 ,  A61L27/16 ,  A61B2017/564 ,  A61B2017/568 ,  A61L2400/06 ,  A61L2430/02

Abstract: A photocurable device injection system for creating in situ polymerization via light or free-radical to enable fractured bone fixation. The system comprises a photosensitive polymeric resin sensitive to light, temperature, oxygen, enzymes, or a combination thereof. The photosensitive polymeric resin may be configured to cure at room temperature or physiological temperature with a light source. The photosensitive polymeric resin may be configured to depolymerize with ultrasonication, sonication, or a combination thereof. The system further comprises an implantable 3-dimensional biocompatible pouch comprising an optical light guide. The system further comprises one or more micro-sized ultrasonication probes configured to contact a three-dimensional pouch by one or more openings. The one or more probes may be configured to enable polymer outflow.

公开(公告)号：US20240335219A1

公开(公告)日：2024-10-10

申请号：US18745396

申请日：2024-06-17

Applicant: Bone Solutions, Inc.

Inventor： Frankie Morris ,  Drew Diaz ,  Brandon Roller

IPC: A61B17/86 ,  A61F2/30 ,  A61F2/44 ,  A61L27/04 ,  A61L27/06 ,  A61L27/12 ,  A61L27/18 ,  A61L27/54 ,  A61L27/56

CPC classification number: A61B17/866 ,  A61F2/30771 ,  A61F2/3094 ,  A61F2/447 ,  A61L27/047 ,  A61L27/06 ,  A61L27/12 ,  A61L27/18 ,  A61L27/54 ,  A61L27/56 ,  A61F2002/30827 ,  A61F2002/30985 ,  A61F2310/00023 ,  A61F2310/00041 ,  A61F2310/00359 ,  A61L2300/102 ,  A61L2300/112 ,  A61L2300/412 ,  A61L2430/02 ,  A61L2430/24 ,  A61L2430/38

Abstract: The present disclosure provides a bone-implantable device and methods of use. The bone-implantable device comprises a body having an exterior surface, wherein a portion of the exterior surface includes a cured osteostimulative material comprising MgO.

公开(公告)号：US12076462B2

公开(公告)日：2024-09-03

申请号：US17018708

申请日：2020-09-11

Applicant: WARSAW ORTHOPEDIC, INC.

Inventor： Gretchen Selders ,  Ian Dunkley

IPC: A61L27/46 ,  A61L27/10 ,  A61L27/12 ,  A61L27/24 ,  A61L27/36 ,  A61L27/56

CPC classification number: A61L27/46 ,  A61L27/10 ,  A61L27/12 ,  A61L27/24 ,  A61L27/3608 ,  A61L27/362 ,  A61L27/365 ,  A61L27/56 ,  A61L2400/06 ,  A61L2430/02

Abstract: A uniformly hydrated composition is provided and methods of making the uniformly hydrated composition. The method comprises providing a plurality of lyophilized porous macroparticles in a chamber, the plurality of lyophilized porous macroparticles each having an average diameter from about 0.1 mm to about 10 mm and comprising ceramic material and polymer; and mixing each of the plurality of lyophilized porous macroparticles with a fluid in the chamber to uniformly hydrate each of the plurality of lyophilized porous macroparticles to form a uniformly hydrated composition. Hydratable compositions are also provided.

公开(公告)号：US20240277846A1

公开(公告)日：2024-08-22

申请号：US18409423

申请日：2024-01-10

Applicant: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION

Inventor： Heemin KANG ,  Woo-Young JANG

IPC: A61K41/00 ,  A61K33/26 ,  A61K47/54 ,  A61L27/04 ,  A61L27/12 ,  A61L27/54 ,  A61P19/00

CPC classification number: A61K41/00 ,  A61K33/26 ,  A61K47/549 ,  A61L27/042 ,  A61L27/12 ,  A61L27/54 ,  A61P19/00 ,  A61L2300/232 ,  A61L2300/412 ,  A61L2430/02

Abstract: A magnetic biomolecule-metal ion self-assembly complex for treatment includes an iron ion; and at least one ligand, wherein the ligand and the iron ion are reversibly self-assembled with each other or self-disassembled from each other, wherein the ligand and the iron ion are self-assembled with each other via a first bond to form a self-assembly, wherein the self-assembling is performed by at least one of the metal ion and the ligand, wherein the self-assembly includes a plural of self-assemblies, wherein the self-assemblies adjacent to each other self-bind to each other via a second bond to form the self-assembly complex. The magnetic biomolecule-metal ion self-assembly complex is effectively used for cancer treatment, osteoarthritis treatment, and bone defect treatment.

公开(公告)号：US20240226378A1

公开(公告)日：2024-07-11

申请号：US18543199

申请日：2023-12-18

Applicant: CARTIHEAL (2009) LTD.

Inventor： Nir ALTSCHULER

IPC: A61L27/36 ,  A61F2/28 ,  A61F2/30 ,  A61L27/12 ,  A61L27/20 ,  A61L27/38 ,  A61L27/40 ,  A61L27/50 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  C01B25/32 ,  C01F11/18 ,  G01N1/00

CPC classification number: A61L27/3608 ,  A61F2/28 ,  A61F2/30 ,  A61F2/30756 ,  A61L27/12 ,  A61L27/20 ,  A61L27/3604 ,  A61L27/3637 ,  A61L27/365 ,  A61L27/3654 ,  A61L27/3834 ,  A61L27/40 ,  A61L27/50 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  C01B25/32 ,  C01F11/18 ,  G01N1/00 ,  A61F2230/0006 ,  A61F2230/0065 ,  A61F2230/0067 ,  A61F2230/0069 ,  A61F2230/0071 ,  A61F2230/0086 ,  A61L2300/112 ,  A61L2300/41 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2300/426 ,  A61L2430/02 ,  A61L2430/06 ,  C01P2006/90

Abstract: This invention provides solid substrates for promoting cell or tissue growth or restored function, which solid substrate is characterized by a specific fluid uptake capacity value of at least 75%, which specific fluid uptake capacity value is determined by establishing a spontaneous fluid uptake value divided by a total fluid uptake value. This invention also provides solid substrates for promoting cell or tissue growth or restored function, which solid substrate is characterized by having a contact angle value of less than 60 degrees, when in contact with a fluid. This invention also provides solid substrates for promoting cell or tissue growth or restored function, which said substrate is characterized by a substantial surface roughness (Ra) as measured by scanning electron microscopy or atomic force microscopy. The invention also provides for processes for selection of an optimized coral-based solid substrate for promoting cell or tissue growth or restored function and applications of the same.

公开(公告)号：US20240207485A1

公开(公告)日：2024-06-27

申请号：US18397950

申请日：2023-12-27

Applicant: Acuitive Technologies, Inc.

Inventor： Minh-Tuan Richard Tran ,  Rui J. Ferreira ,  Michael P. McCarthy

IPC: A61L27/36 ,  A61L27/12 ,  A61L27/40 ,  A61L27/52 ,  A61L27/56

CPC classification number: A61L27/3654 ,  A61L27/12 ,  A61L27/40 ,  A61L27/52 ,  A61L27/56 ,  A61L2430/02

Abstract: The present disclosure provides citrate-based constructs for use in the repair of osteochondral defects. The constructs generally include: (i) a citrate component, (ii) a diol component, (iii) a polyol, and (iv) particulate inorganic material. The scaffold may take the form of a 50-90% porous scaffold and may form a polymer network. The scaffold may be soaked in a hyaluronic acid solution and may be freeze-dried to produce a porous construct within the pores of the scaffold. The scaffold may be biphasic, containing a porous section for subchondral bone regeneration and a citrate-based polymer hydrogel for cartilage regeneration. The scaffold may form an implant and the implant may include an inner porous core of a biphasic core-shell construct.

公开(公告)号：US11969349B2

公开(公告)日：2024-04-30

申请号：US17199920

申请日：2021-03-12

Applicant: Collagen Matrix, Inc.

Inventor： Shu-Tung Li ,  Hui-Chen Chen ,  Debbie Yuen

IPC: A61F2/28 ,  A61F2/30 ,  A61L27/12 ,  A61L27/24 ,  A61L27/38 ,  A61L27/54 ,  A61L27/58

CPC classification number: A61F2/28 ,  A61F2/30756 ,  A61L27/12 ,  A61L27/24 ,  A61L27/3847 ,  A61L27/3852 ,  A61L27/54 ,  A61L27/58 ,  A61F2002/2839 ,  A61F2002/30016 ,  A61F2002/30062 ,  A61F2002/30293 ,  A61F2002/3092 ,  A61F2310/00371 ,  A61L2430/02 ,  A61L2430/06

Abstract: An implant for the repair of bone and cartilage that includes a cell conductive zone that contains biopolymeric fibers and an osteoconductive zone that contains biopolymeric fibers and calcium-containing mineral particles. The biopolymeric fibers from one zone overlap with the fibers in the other zone forming a stable physical and mechanical integration of the two zones, thus conferring in vivo stability to the implant.

公开(公告)号：US20240091416A1

公开(公告)日：2024-03-21

申请号：US18460146

申请日：2023-09-01

Applicant: Heraeus Medical GmbH

Inventor： Sebastian VOGT ,  Thomas KLUGE

IPC: A61L27/54 ,  A61K31/7036 ,  A61K31/7056 ,  A61K38/14 ,  A61K47/02 ,  A61K47/34 ,  A61L27/04 ,  A61L27/12 ,  A61L27/18

CPC classification number: A61L27/54 ,  A61K31/7036 ,  A61K31/7056 ,  A61K38/14 ,  A61K47/02 ,  A61K47/34 ,  A61L27/047 ,  A61L27/12 ,  A61L27/18 ,  A61L2300/232 ,  A61L2300/25 ,  A61L2300/404 ,  A61L2430/02

Abstract: A composition for producing a bone replacement material, which composition reacts with water or an aqueous solution in a cementitious setting reaction and forms a solid body. Additionally disclosed is a method for producing a pharmaceutical excipient having the aforementioned composition, the pharmaceutical excipient produced in this way, and the use of such a composition or such a pharmaceutical excipient for the local release of at least one pharmaceutical active ingredient.

公开(公告)号：US20240024534A1

公开(公告)日：2024-01-25

申请号：US18377058

申请日：2023-10-05

Applicant: Advanced Biologics, LLC

Inventor： Amit Prakash Govil ,  Christian Gamboa

IPC: A61L27/20 ,  A61F2/46 ,  A61L27/12 ,  A61L27/54 ,  A61L27/50 ,  A61L27/36 ,  A61K35/32 ,  C08L5/08 ,  A61L27/38 ,  A61K35/28

CPC classification number: A61L27/20 ,  A61F2/4644 ,  A61L27/12 ,  A61L27/54 ,  A61L27/50 ,  A61L27/365 ,  A61L27/3608 ,  A61K35/32 ,  C08L5/08 ,  A61L27/3821 ,  A61L27/3834 ,  A61K35/28 ,  A61L27/3687 ,  A61L2400/16 ,  A61L2300/60 ,  A61F2002/4646 ,  A61L2430/02 ,  A61L2300/62 ,  A61L2300/45 ,  A61L2300/412 ,  A61L2300/404 ,  A61L2300/232 ,  A61L2300/406

Abstract: Disclosed are various bioactive and/or biocompatible materials and methods of making the same.

公开(公告)号：US20240009373A1

公开(公告)日：2024-01-11

申请号：US18372766

申请日：2023-09-26

Applicant: Marcus JAEGER

Inventor： Marcus JAEGER

IPC: A61M1/00 ,  A61L27/12

CPC classification number: A61M1/79 ,  A61L27/12 ,  A61B2217/005 ,  A61L27/3608

Abstract: A filter assembly for a surgical suction system. The filter assembly has a containment defining a filter chamber an intake fitting on an upstream end of the chamber, an output fitting on an opposite downstream end of the chamber, and a filter element in the filter chamber and made at least partially of a bioresorbable bone substitute so that autologous tissue components carried in a fluid flowing from the fitting through the filter element in the filter chamber are trapped by the filter element.