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1.发明授权Dicalcium phosphate ceramics, dicalcium phosphate/hydroxyapatite biphasic ceramics and method of manufacturing the same 有权磷酸二钙陶瓷，磷酸二钙/羟基磷灰石双相陶瓷及其制造方法公开(公告)号：US08962037B2
公开(公告)日：2015-02-24
申请号：US13023318
申请日：2011-02-08
Applicant: Sung-Tsuen Liu , Sung-Ching Chen , Hui-Chun Lai , Wan-Ting Huang
Inventor： Sung-Tsuen Liu , Sung-Ching Chen , Hui-Chun Lai , Wan-Ting Huang
IPC: A01N59/24 , A61K6/083 , C01B15/16 , C04B35/447 , A61L27/12 , A61L27/56 , C01B25/32 , C04B38/04 , C04B111/00
CPC classification number: C04B35/447 , A61L27/12 , A61L27/56 , A61L2430/02 , A61L2430/12 , C01B25/32 , C04B38/04 , C04B2111/00836 , C04B2235/3212 , C04B2235/5427 , C04B2235/606
Abstract: The present invention discloses a method of manufacturing pure dicalcium phosphate ceramics or dicalcium phosphate/hydroxyapaite (HA) biphasic ceramics for medical applications in hard tissue areas to be used as implant materials. These ceramic implant materials are in granular form or in block form, and are prepared by using an acidic phosphate compound, a basic calcium phosphate compound comprising HA, and water. The dicalcium phosphate ceramic comprises either dicalcium phosphate dihydrate (CaHPO4.2H2O, DCPD) or dicalcium anhydrous (CaHPO4, DCPA). Wherein, when the acidic phosphate compound is provided in an amount stoichiometrically equal to or in excess relative to the basic calcium phosphate compound, a reaction product is the DCPD or DCPA ceramic; when the acidic phosphate compound is provided in the amount stoichiometrically less than the basic calcium phosphate compound, the reaction product is the DCPD/HA or DCPA/HA biphasic ceramic.
Abstract translation: 本发明公开了一种制造纯磷酸二钙陶瓷或磷酸二钙/羟基磷灰石（HA）双相陶瓷的方法，用于在硬组织区域中用作植入材料的医疗应用。 这些陶瓷植入材料为颗粒形式或块状，并且通过使用酸性磷酸盐化合物，包含HA的碱式磷酸钙化合物和水来制备。 磷酸二钙陶瓷包括磷酸二钙二水合物（CaHPO 4·2H 2 O，DCPD）或无水二钙（CaHPO 4，DCPA）。 其中，当酸性磷酸盐化合物以相对于碱式磷酸钙化合物的化学计量等于或过量的量提供时，反应产物是DCPD或DCPA陶瓷; 当酸化磷酸盐化合物以化学计量比碱性磷酸钙化合物的量提供时，反应产物是DCPD / HA或DCPA / HA双相陶瓷。
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公开(公告)号：US08603092B2
公开(公告)日：2013-12-10
申请号：US12830536
申请日：2010-07-06
Applicant: Chun-Jen Liao , Ching-Chuan Jiang , Sung-Ching Chen , Pei-Chi Hsu , Shih-Jui Han
Inventor： Chun-Jen Liao , Ching-Chuan Jiang , Sung-Ching Chen , Pei-Chi Hsu , Shih-Jui Han
CPC classification number: A61F2/3859 , A61B17/1637 , A61B17/1668 , A61B17/742 , A61B2017/00969 , A61F2/28 , A61F2/30721 , A61F2/30756 , A61F2/3094 , A61F2/4644 , A61F2002/2828 , A61F2002/2832 , A61F2002/30059 , A61F2002/30062 , A61F2002/30766
Abstract: A bone repairing kit including a drilling device, a pushing device, a clamping member and a hole saw is provided. An end of a tube body of the drilling device is a knife portion. When the tube body rotates with respect to a femur, a bone column is cut by the knife portion and located in the tube body. The pushing device includes a hollow tube and a push bar. The hollow tube is for receiving the tube body. The push bar is for touching and pushing the bone column in the tube body. The clamping member is for clamping the bone column. The hole saw includes a receiving body and cutting knives. The receiving body has a recess for receiving an end of the bone column. The cutting knives surrounding on an inner wall of the recess are for cutting an edge of the end of the bone column.
Abstract translation: 提供了包括钻孔装置，推动装置，夹紧构件和孔锯的骨修复工具。 钻孔装置的管体的端部是刀部。 当管体相对于股骨旋转时，骨柱由刀部分切割并位于管体中。 推动装置包括中空管和推杆。 中空管用于容纳管体。 推杆用于接触并推动管体中的骨柱。 夹紧构件用于夹紧骨柱。 孔锯包括接收体和切割刀。 接收体具有用于接收骨柱端部的凹部。 围绕凹槽内壁的切割刀片用于切割骨柱端部的边缘。
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Patent Agency Ranking
3.发明申请Mineralized Collagen/Bioceramic Composite and Manufacturing Method Thereof 审中-公开矿化胶原/生物陶瓷复合材料及其制造方法公开(公告)号：US20120207839A1
公开(公告)日：2012-08-16
申请号：US13026729
申请日：2011-02-14
Applicant: SUNG-TSUEN LIU , SUNG-CHING CHEN , WAN-CHING HSU
Inventor： SUNG-TSUEN LIU , SUNG-CHING CHEN , WAN-CHING HSU
CPC classification number: A61L27/46 , A61L2430/02 , C08L89/06
Abstract: The present invention discloses a mineralized collagen/bioceramic composite useful as a hard tissue replacement material or substitute material, comprising about 10% to 95% by weight of mineralized collagen and about 5% to 90% by weight of bioceramics, and a method of manufacturing the same. Wherein, the mineralized collagen is used as a binder for the bioceramics, such as calcium phosphate ceramics, calcium sulfate ceramics, calcium carbonate ceramics, and other biocompatible ceramics. The bioceramic used in the mineralized collagen/bioceramic composite can be either in powder form or in granular form.
Abstract translation: 本发明公开了一种矿化胶原/生物陶瓷复合材料，其用作硬组织替代材料或替代材料，其包含约10重量％至95重量％的矿化胶原和约5重量％至90重量％的生物陶瓷，以及制造方法 一样。 其中，矿化胶原用作生物陶瓷的粘合剂，如磷酸钙陶瓷，硫酸钙陶瓷，碳酸钙陶瓷和其他生物相容性陶瓷。 矿化胶原/生物陶瓷复合材料中使用的生物陶瓷可以是粉末状或颗粒状。
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4.发明授权Surgical calcium phosphate citrate-containing cement and method of manufacturing the same 有权手术中含磷酸钙的柠檬酸钙水泥及其制造方法相同公开(公告)号：US08414930B2
公开(公告)日：2013-04-09
申请号：US13004560
申请日：2011-01-11
Applicant: Sung-Tsuen Liu , Sung-Ching Chen , Hui-Chun Lai , Kehsin Chien
Inventor： Sung-Tsuen Liu , Sung-Ching Chen , Hui-Chun Lai , Kehsin Chien
IPC: C04B35/00
CPC classification number: A61L24/0084 , A61L24/0015 , A61L24/0042 , A61L24/0089
Abstract: The present invention discloses a surgical cement and a manufacturing method thereof. The surgical cement comprises a cementing component selected form the group of a basic calcium phosphate consisting of tetracalcium phosphate, alpha-tricalcium phosphate, decomposed hydroxyapatite, or a combination thereof; a setting reagent selected form the group of an acidic calcium citrate consisting of monocalcium citrate, dicalcium citrate, or a combination thereof; and water; wherein a weight ratio of the cementing component and the setting reagent ranges from about 1:1 to about 8:1. The surgical cement is bioresorbable and bioactive and is useful in orthopedic, maxillofacial and dental applications. In addition, the surgical cement of this invention has a good flow character and a relatively short setting time.
Abstract translation: 本发明公开了一种外科手术水泥及其制造方法。 手术水泥包括选自由磷酸四钙，磷酸α-磷酸三钙，分解羟基磷灰石或其组合组成的碱性磷酸钙组的粘合组分; 选自柠檬酸一柠檬酸钙，柠檬酸二钙或其组合的酸性柠檬酸钙组的凝固试剂; 和水; 其中所述粘合组分和凝固剂的重量比范围为约1:1至约8:1。 手术水泥是生物可再吸收和生物活性的，可用于矫形，颌面和牙科应用。 此外，本发明的外科手术水泥具有良好的流动特性和较短的凝固时间。
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5.发明申请公开(公告)号：US20120178684A1
公开(公告)日：2012-07-12
申请号：US13004560
申请日：2011-01-11
Applicant: SUNG-TSUEN LIU , SUNG-CHING CHEN , HUI-CHUN LAI , KEHSIN CHIEN
Inventor： SUNG-TSUEN LIU , SUNG-CHING CHEN , HUI-CHUN LAI , KEHSIN CHIEN
CPC classification number: A61L24/0084 , A61L24/0015 , A61L24/0042 , A61L24/0089
Abstract: The present invention discloses a surgical cement and a manufacturing method thereof. The surgical cement comprises a cementing component selected form the group of a basic calcium phosphate consisting of tetracalcium phosphate, alpha-tricalcium phosphate, decomposed hydroxyapatite, or a combination thereof; a setting reagent selected form the group of an acidic calcium citrate consisting of monocalcium citrate, dicalcium citrate, or a combination thereof; and water; wherein a weight ratio of the cementing component and the setting reagent ranges from about 1:1 to about 8:1. The surgical cement is bioresorbable and bioactive and is useful in orthopedic, maxillofacial and dental applications. In addition, the surgical cement of this invention has a good flow character and a relatively short setting time.
Abstract translation: 本发明公开了一种外科手术水泥及其制造方法。 手术水泥包括选自由磷酸四钙，磷酸α-磷酸三钙，分解的羟基磷灰石或其组合组成的碱性磷酸钙组的粘合组分; 选自柠檬酸一柠檬酸钙，柠檬酸二钙或其组合的酸性柠檬酸钙组的凝固试剂; 和水; 其中所述粘合组分和凝固剂的重量比范围为约1:1至约8:1。 手术水泥是生物可再吸收和生物活性的，可用于矫形，颌面和牙科应用。 此外，本发明的外科手术水泥具有良好的流动特性和较短的凝固时间。
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公开(公告)号：US20110160732A1
公开(公告)日：2011-06-30
申请号：US12830536
申请日：2010-07-06
Applicant: Chun-Jen Liao , Ching-Chuan Jiang , Sung-Ching Chen , Pei-Chi Hsu , Shih-Jui Han
Inventor： Chun-Jen Liao , Ching-Chuan Jiang , Sung-Ching Chen , Pei-Chi Hsu , Shih-Jui Han
CPC classification number: A61F2/3859 , A61B17/1637 , A61B17/1668 , A61B17/742 , A61B2017/00969 , A61F2/28 , A61F2/30721 , A61F2/30756 , A61F2/3094 , A61F2/4644 , A61F2002/2828 , A61F2002/2832 , A61F2002/30059 , A61F2002/30062 , A61F2002/30766
Abstract: A bone repairing kit including a drilling device, a pushing device, a clamping member and a hole saw is provided. An end of a tube body of the drilling device is a knife portion. When the tube body rotates with respect to a femur, a bone column is cut by the knife portion and located in the tube body. The pushing device includes a hollow tube and a push bar. The hollow tube is for receiving the tube body. The push bar is for touching and pushing the bone column in the tube body. The clamping member is for clamping the bone column. The hole saw includes a receiving body and cutting knives. The receiving body has a recess for receiving an end of the bone column. The cutting knives surrounding on an inner wall of the recess are for cutting an edge of the end of the bone column.
Abstract translation: 提供了包括钻孔装置，推动装置，夹紧构件和孔锯的骨修复工具。 钻孔装置的管体的端部是刀部。 当管体相对于股骨旋转时，骨柱由刀部分切割并位于管体中。 推动装置包括中空管和推杆。 中空管用于容纳管体。 推杆用于接触并推动管体中的骨柱。 夹紧构件用于夹紧骨柱。 孔锯包括接收体和切割刀。 接收体具有用于接收骨柱端部的凹部。 围绕凹槽内壁的切割刀片用于切割骨柱端部的边缘。
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7.发明申请Dicalcium Phosphate Ceramics, Dicalcium Phosphate/Hydroxyapatite Biphasic Ceramics and Method of Manufacturing the Same 有权磷酸二钙陶瓷，磷酸二钙/羟基磷灰石双相陶瓷及其制造方法公开(公告)号：US20120201870A1
公开(公告)日：2012-08-09
申请号：US13023318
申请日：2011-02-08
Applicant: SUNG-TSUEN LIU , SUNG-CHING CHEN , HUI-CHUN LAI , WAN-TING HUANG
Inventor： SUNG-TSUEN LIU , SUNG-CHING CHEN , HUI-CHUN LAI , WAN-TING HUANG
CPC classification number: C04B35/447 , A61L27/12 , A61L27/56 , A61L2430/02 , A61L2430/12 , C01B25/32 , C04B38/04 , C04B2111/00836 , C04B2235/3212 , C04B2235/5427 , C04B2235/606
Abstract: The present invention discloses a method of manufacturing pure dicalcium phosphate ceramics or dicalcium phosphate/hydroxyapaite (HA) biphasic ceramics for medical applications in hard tissue areas to be used as implant materials. These ceramic implant materials are in granular form or in block form, and are prepared by using an acidic phosphate compound, a basic calcium phosphate compound comprising HA, and water. The dicalcium phosphate ceramic comprises either dicalcium phosphate dihydrate (CaHPO4.2H2O, DCPD) or dicalcium anhydrous (CaHPO4, DCPA). Wherein, when the acidic phosphate compound is provided in an amount stoichiometrically equal to or in excess relative to the basic calcium phosphate compound, a reaction product is the DCPD or DCPA ceramic; when the acidic phosphate compound is provided in the amount stoichiometrically less than the basic calcium phosphate compound, the reaction product is the DCPD/HA or DCPA/HA biphasic ceramic.
Abstract translation: 本发明公开了一种制造纯磷酸二钙陶瓷或磷酸二钙/羟基磷灰石（HA）双相陶瓷的方法，用于在硬组织区域中用作植入材料的医疗应用。 这些陶瓷植入材料为颗粒形式或块状，并且通过使用酸性磷酸盐化合物，包含HA的碱式磷酸钙化合物和水来制备。 磷酸二钙陶瓷包括磷酸二钙二水合物（CaHPO 4·2H 2 O，DCPD）或无水二钙（CaHPO 4，DCPA）。 其中，当酸性磷酸盐化合物以相对于碱式磷酸钙化合物的化学计量等于或过量的量提供时，反应产物是DCPD或DCPA陶瓷; 当酸化磷酸盐化合物以化学计量比碱性磷酸钙化合物的量提供时，反应产物是DCPD / HA或DCPA / HA双相陶瓷。
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