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公开(公告)号：US20110152330A1
公开(公告)日：2011-06-23
申请号：US13035625
申请日：2011-02-25
申请人： Derek B. Lowe , Philip L. Wickens , Xin Ma , Mingbao Zhang , William H. Bullock , Philip D. G. Coish , Ingo A. Mugge , Andreas Stolle , Ming Wang , Yamin Wang , Chengzhi Zhang , Hai-Jun Zhang , Lei Zhu , Manami Tsutsumi , James N. Livingston
发明人： Derek B. Lowe , Philip L. Wickens , Xin Ma , Mingbao Zhang , William H. Bullock , Philip D. G. Coish , Ingo A. Mugge , Andreas Stolle , Ming Wang , Yamin Wang , Chengzhi Zhang , Hai-Jun Zhang , Lei Zhu , Manami Tsutsumi , James N. Livingston
IPC分类号： A61K31/421 , C07D263/32 , A61P3/04 , A61P3/10 , A61P9/00 , A61P9/12 , A61P3/06 , A61P17/00 , A61P35/00
CPC分类号： C07D277/32 , C07B2200/07 , C07C51/412 , C07C51/44 , C07C59/72 , C07C69/732 , C07C69/734 , C07C69/738 , C07C2602/08 , C07D263/32 , C07D277/24 , C07D277/40 , C07D413/04 , C07D413/10 , C07D413/12
摘要： This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.
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2.发明申请4-(3-AMINOPYRAZOLE) PYRIMIDINE DERIVATIVES FOR USE AS TYROSINE KINASE INHIBITORS IN THE TREATMENT OF CANCER 失效在治疗癌症中用作酪氨酸激酶抑制剂的4-（3-氨基吡唑）吡嗪衍生物公开(公告)号：US20100160325A1
公开(公告)日：2010-06-24
申请号：US12713695
申请日：2010-02-26
申请人： Xiaomei Feng , Huiping Guan , Stephanos Ioannidis , Bo Peng , Mei Su , Tao Wang , Hai-Jun Zhang , Ying Kan , Bin Wang
发明人： Xiaomei Feng , Huiping Guan , Stephanos Ioannidis , Bo Peng , Mei Su , Tao Wang , Hai-Jun Zhang , Ying Kan , Bin Wang
IPC分类号： A61K31/5377 , C07D403/14 , A61K31/506 , C07D413/14 , A61P35/00 , A61P35/02 , A61P35/04
CPC分类号： C07D403/14
摘要： This invention relates to novel compounds having the formula (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment for cancer.
摘要翻译： 本发明涉及具有式（I）的新化合物及其药物组合物及其使用方法。 这些新型化合物为癌症提供治疗。
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3.发明申请Indane Acetic Acid Derivatives and Their Use as Pharmaceutical Agents, Intermediates, and Method of Preparation 审中-公开吲哚乙酸衍生物及其作为药剂，中间体和制备方法的用途公开(公告)号：US20090047687A1
公开(公告)日：2009-02-19
申请号：US12059706
申请日：2008-03-31
申请人： Derek B. Lowe , Philip L. Wickens , Xin Ma , Mingbao Zhang , William H. Bullock , Philip D. G. Coish , Ingo A. Mugge , Andreas Stolle , Ming Wang , Yamin Wang , Chengzhi Zhang , Hai-Jun Zhang , Lei Zhu , Manami Tsutsumi , James N. Livingston
发明人： Derek B. Lowe , Philip L. Wickens , Xin Ma , Mingbao Zhang , William H. Bullock , Philip D. G. Coish , Ingo A. Mugge , Andreas Stolle , Ming Wang , Yamin Wang , Chengzhi Zhang , Hai-Jun Zhang , Lei Zhu , Manami Tsutsumi , James N. Livingston
IPC分类号： G01N33/53 , C07C69/76 , C07C63/00 , C07D263/30 , C07D277/20 , C07C229/00
CPC分类号： C07D277/32 , C07B2200/07 , C07C51/412 , C07C51/44 , C07C59/72 , C07C67/303 , C07C69/732 , C07C69/734 , C07C69/738 , C07C2602/08 , C07D263/32 , C07D277/24 , C07D277/40 , C07D413/04 , C07D413/10 , C07D413/12 , Y02P20/582
摘要： This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.
摘要翻译： 本发明涉及可用于治疗疾病如糖尿病，肥胖症，高脂血症和动脉粥样硬化疾病的新型茚满乙酸衍生物。 本发明还涉及可用于制备茚满乙酸衍生物的中间体及其制备方法。
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公开(公告)号：US08541618B2
公开(公告)日：2013-09-24
申请号：US13035625
申请日：2011-02-25
申请人： Derek B. Lowe , Philip L. Wickens , Xin Ma , Mingbao Zhang , William H. Bullock , Philip D. G. Coish , Ingo A. Mugge , Andreas Stolle , Ming Wang , Yamin Wang , Chengzhi Zhang , Hai-Jun Zhang , Lei Zhu , Manami Tsutsumi , James N. Livingston
发明人： Derek B. Lowe , Philip L. Wickens , Xin Ma , Mingbao Zhang , William H. Bullock , Philip D. G. Coish , Ingo A. Mugge , Andreas Stolle , Ming Wang , Yamin Wang , Chengzhi Zhang , Hai-Jun Zhang , Lei Zhu , Manami Tsutsumi , James N. Livingston
CPC分类号： C07D277/32 , C07B2200/07 , C07C51/412 , C07C51/44 , C07C59/72 , C07C69/732 , C07C69/734 , C07C69/738 , C07C2602/08 , C07D263/32 , C07D277/24 , C07D277/40 , C07D413/04 , C07D413/10 , C07D413/12
摘要： This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.
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![9-(pyrazol-3-yl)-9H-purine-2-amine and 3-(pyrazol-3-yl) -3H-imidazo[4,5-B] pyridin-5-amine derivatives and their use for the treatment of cancer](/abs-image/US/2013/07/16/US08486966B2/abs.jpg.150x150.jpg)
5.发明授权9-(pyrazol-3-yl)-9H-purine-2-amine and 3-(pyrazol-3-yl) -3H-imidazo[4,5-B] pyridin-5-amine derivatives and their use for the treatment of cancer 失效9-（吡唑-3-基）-9H-嘌呤-2-胺和3-（吡唑-3-基）-3H-咪唑并[4,5-B]吡啶-5-胺衍生物及其用于治疗 的癌症公开(公告)号：US08486966B2
公开(公告)日：2013-07-16
申请号：US12598473
申请日：2008-05-02
申请人： Audrey Davies , Stephanos Ioannidis , Michelle Lamb , Mei Su , Tao Wang , Hai-Jun Zhang
发明人： Audrey Davies , Stephanos Ioannidis , Michelle Lamb , Mei Su , Tao Wang , Hai-Jun Zhang
IPC分类号： A01N43/42 , A61K31/44 , C07D471/02 , C07D491/02 , C07D498/02
CPC分类号： C07D471/04 , C07D471/22 , C07D473/16 , C07D473/18 , C07D473/32 , C07D491/22 , C07D498/22
摘要： The present invention relates to compounds of Formula (I): and to their pharmaceutical compositions, and to their methods of use. These compounds provide a treatment for myeloproliferative disorders and cancer.
摘要翻译： 本发明涉及式（I）化合物及其药物组合物及其使用方法。 这些化合物提供骨髓增生性疾病和癌症的治疗。
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![9-(PYRAZOL-3-YL)-9H-PURINE-2-AMINE AND 3-(PYRAZOL-3-YL) -3H-IMIDAZO[4,5-B] PYRIDIN-5- AMINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CANCER](/abs-image/US/2010/12/23/US20100324040A1/abs.jpg.150x150.jpg)
6.发明申请9-(PYRAZOL-3-YL)-9H-PURINE-2-AMINE AND 3-(PYRAZOL-3-YL) -3H-IMIDAZO[4,5-B] PYRIDIN-5- AMINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CANCER 失效9-（吡唑-3-基）-9H-嘌呤-2-胺和3-（吡唑-3-基）-3H-咪唑并[4,5-B]吡啶-5-胺衍生物及其用于治疗的用途 癌症公开(公告)号：US20100324040A1
公开(公告)日：2010-12-23
申请号：US12598473
申请日：2008-05-02
申请人： Audrey Davies , Stephanos Ioannidis , Michelle Lamb , Mei Su , Tao Wang , Hai-Jun Zhang
发明人： Audrey Davies , Stephanos Ioannidis , Michelle Lamb , Mei Su , Tao Wang , Hai-Jun Zhang
IPC分类号： A61K31/5377 , C07D471/04 , C07D473/32 , A61K31/437 , A61K31/52 , A61K31/506 , A61P35/00
CPC分类号： C07D471/04 , C07D471/22 , C07D473/16 , C07D473/18 , C07D473/32 , C07D491/22 , C07D498/22
摘要： The present invention relates to compounds of Formula (I): and to their pharmaceutical compositions, and to their methods of use. These compounds provide a treatment for myeloproliferative disorders and cancer.
摘要翻译： 本发明涉及式（I）化合物及其药物组合物及其使用方法。 这些化合物提供骨髓增生性疾病和癌症的治疗。
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7.发明申请4-(3-Aminopyrazole) Pyrimidine Derivatives for Use as Tyrosine Kinase Inhibitors in the Treatment of Cancer 审中-公开用作酪氨酸激酶抑制剂治疗癌症的4-（3-氨基吡唑）嘧啶衍生物公开(公告)号：US20080287475A1
公开(公告)日：2008-11-20
申请号：US12091382
申请日：2006-10-26
申请人： Xiaomei Feng , Huiping Guan , Ying Kan , Stephanos Ioannidis , Bo Peng , Mei Su , Bin Wang , Tao Wang , Hai-Jun Zhang
发明人： Xiaomei Feng , Huiping Guan , Ying Kan , Stephanos Ioannidis , Bo Peng , Mei Su , Bin Wang , Tao Wang , Hai-Jun Zhang
IPC分类号： A61K31/506 , A61P35/00 , C07D403/14 , C07D413/14
CPC分类号： C07D403/14
摘要： This invention relates to novel compounds having the formula (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment for cancer.
摘要翻译： 本发明涉及具有式（I）的新化合物及其药物组合物及其使用方法。 这些新型化合物为癌症提供治疗。
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8.发明授权Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation 有权茚基乙酸衍生物及其作为药剂，中间体和制备方法的用途公开(公告)号：US07358386B2
公开(公告)日：2008-04-15
申请号：US11429136
申请日：2006-05-05
申请人： Derek B. Lowe , Philip L. Wickens , Xin Ma , Mingbao Zhang , William H. Bullock , Philip D. G. Coish , Ingo Mugge , Andreas Stolle , Ming Wang , Yamin Wang , Chengzhi Zhang , Hai-Jun Zhang , Lei Zhu , Manami Tsutsumi , James N. Livingston
发明人： Derek B. Lowe , Philip L. Wickens , Xin Ma , Mingbao Zhang , William H. Bullock , Philip D. G. Coish , Ingo Mugge , Andreas Stolle , Ming Wang , Yamin Wang , Chengzhi Zhang , Hai-Jun Zhang , Lei Zhu , Manami Tsutsumi , James N. Livingston
IPC分类号： C07C69/76 , C07C59/00 , C07D277/20 , C07D413/00
CPC分类号： C07D277/32 , C07B2200/07 , C07C51/412 , C07C51/44 , C07C59/72 , C07C67/303 , C07C69/732 , C07C69/734 , C07C69/738 , C07C2602/08 , C07D263/32 , C07D277/24 , C07D277/40 , C07D413/04 , C07D413/10 , C07D413/12 , Y02P20/582
摘要： This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.
摘要翻译： 本发明涉及可用于治疗疾病如糖尿病，肥胖症，高脂血症和动脉粥样硬化疾病的新型茚满乙酸衍生物。 本发明还涉及可用于制备茚满乙酸衍生物的中间体及其制备方法。
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9.发明授权Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation 有权茚基乙酸衍生物及其作为药剂，中间体和制备方法的用途公开(公告)号：US06828335B2
公开(公告)日：2004-12-07
申请号：US10205839
申请日：2002-07-25
申请人： Derek B. Lowe , Philip L. Wickens , Xin Ma , Mingbao Zhang , William H. Bullock , Philip D. G. Coish , Ingo A. Mugge , Andreas Stolle , Ming Wang , Yamin Wang , Chengzhi Zhang , Hai-Jun Zhang , Lei Zhu , Manami Tsutsumi , James N. Livingston
发明人： Derek B. Lowe , Philip L. Wickens , Xin Ma , Mingbao Zhang , William H. Bullock , Philip D. G. Coish , Ingo A. Mugge , Andreas Stolle , Ming Wang , Yamin Wang , Chengzhi Zhang , Hai-Jun Zhang , Lei Zhu , Manami Tsutsumi , James N. Livingston
IPC分类号： A61K31421
CPC分类号： C07D277/32 , C07B2200/07 , C07C51/412 , C07C51/44 , C07C59/72 , C07C67/303 , C07C69/732 , C07C69/734 , C07C69/738 , C07C2602/08 , C07D263/32 , C07D277/24 , C07D277/40 , C07D413/04 , C07D413/10 , C07D413/12 , Y02P20/582
摘要： This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.
摘要翻译： 本发明涉及可用于治疗疾病如糖尿病，肥胖症，高脂血症和动脉粥样硬化疾病的新型茚满乙酸衍生物。 本发明还涉及可用于制备茚满乙酸衍生物的中间体及其制备方法。
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公开(公告)号：US08552203B2
公开(公告)日：2013-10-08
申请号：US13035638
申请日：2011-02-25
申请人： Derek B. Lowe , Philip L. Wickens , Xin Ma , Mingbao Zhang , William H. Bullock , Philip D. G. Coish , Ingo A. Mugge , Andreas Stolle , Ming Wang , Yamin Wang , Chengzhi Zhang , Hai-Jun Zhang , Lei Zhu , Manami Tsutsumi , James N. Livingston
发明人： Derek B. Lowe , Philip L. Wickens , Xin Ma , Mingbao Zhang , William H. Bullock , Philip D. G. Coish , Ingo A. Mugge , Andreas Stolle , Ming Wang , Yamin Wang , Chengzhi Zhang , Hai-Jun Zhang , Lei Zhu , Manami Tsutsumi , James N. Livingston
IPC分类号： C07D277/22 , C07D263/30
CPC分类号： C07D277/32 , C07B2200/07 , C07C51/412 , C07C51/44 , C07C59/72 , C07C69/732 , C07C69/734 , C07C69/738 , C07C2602/08 , C07D263/32 , C07D277/24 , C07D277/40 , C07D413/04 , C07D413/10 , C07D413/12
摘要： This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.
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