公开(公告)号：US5681979A

公开(公告)日：1997-10-28

申请号：US609374

申请日：1996-03-01

申请人： Hajime Hoshi ,  Satoru Kumazawa

发明人： Hajime Hoshi ,  Satoru Kumazawa

IPC分类号： C07C67/343 ,  C07B61/00 ,  C07C69/757 ,  C07C201/12 ,  C07C205/61 ,  C07C253/30 ,  C07C255/57 ,  C07D233/60 ,  C07D249/08 ,  C07C69/76

CPC分类号： C07C69/757

摘要： The present invention provides a process for producing alkylcyclopentanone derivatives of formula (1) by reacting alkyl cyclopentanone derivatives of formula (2) and alkyl halides of formula (3) in an organic solvent in the presence of molecular sieves and an alkaline metal hydroxide: ##STR1## wherein R.sup.1 is C.sub.1 -C.sub.4 alkyl group; R.sup.2 is hydrogen atom or C.sub.1 -C.sub.5 alkyl group; R.sup.3 is C.sub.1 -C.sub.5 alkyl group; Y is halogen atom, C.sub.1 -C.sub.5 alkyl group, C.sub.1 -C.sub.5 haloalkyl group, phenyl group, cyano group or nitro group; n is an integer from 0 to 5; when n is 2 or greater, Y's may be identical or different; R.sup.3 in formula (3) is the same as R.sup.3 in formula (1); and a process for preparing alkylcyclopentanone derivatives of formula (5) by reacting cyclopentanone derivatives of formula (4) and alkyl halides of formula (6) in an organic solvent in the presence of molecular sieves and an alkaline metal hydroxide: ##STR2## wherein R.sup.1 is C.sub.1 -C.sub.4 alkyl group; R.sup.4 is hydrogen atom or C.sub.1 -C.sub.5 alkyl group; R.sup.5 is C.sub.1 -C.sub.5 alkyl group; R.sup.k is either R.sup.4 or R.sup.5 ; Y is halogen atom, C.sub.1 -C.sub.5 alkyl group, C.sub.1 -C.sub.5 haloalkyl group, phenyl group, cyano group or nitro group; n is an integer from 0 to 5; when n is 2 or greater, Y's may be identical or different.

摘要翻译： 本发明提供了在分子筛和碱金属氢氧化物的存在下，通过使式（2）的烷基环戊酮衍生物与式（3）的烷基卤衍生物在有机溶剂中反应制备式（1）的烷基环戊酮衍生物的方法： （1）图像（2）R3X（3）其中R1是C1-C4烷基; R2是氢原子或C1-C5烷基; R3是C1-C5烷基; Y是卤素原子，C1-C5烷基，C1-C5卤代烷基，苯基，氰基或硝基; n为0〜5的整数， 当n为2以上时，Y可以相同或不同; 式（3）中的R 3与式（1）中的R 3相同; （4）的环戊酮衍生物和式（6）的烷基卤在有机溶剂中在分子筛和碱金属氢氧化物存在下制备式（5）的烷基环戊酮衍生物的方法： （5）RkX（6）其中R1是C1-C4烷基; R4是氢原子或C1-C5烷基; R5是C1-C5烷基; Rk是R4或R5; Y是卤素原子，C1-C5烷基，C1-C5卤代烷基，苯基，氰基或硝基; n为0〜5的整数， 当n为2以上时，Y可以相同也可以不同。

公开(公告)号：US5279719A

公开(公告)日：1994-01-18

申请号：US970305

申请日：1992-11-02

申请人： Kazuhiko Sunagawa ,  Hajime Hoshi ,  Tsumoru Watanabe

发明人： Kazuhiko Sunagawa ,  Hajime Hoshi ,  Tsumoru Watanabe

IPC分类号： C07C17/12 ,  C07C17/14 ,  C07C25/02 ,  C07C25/125 ,  C07C25/22 ,  C07C17/00

CPC分类号： C07C17/12 ,  C07C17/14 ,  C07C25/125

摘要： A process for chlorination of methylated aromatic compounds in a titanium tetrachloride is disclosed. The ring chlorination is first carried out by reacting said methylated aromatic compounds with chlorine gas under reduced light conditions, and then the side chain chlorination is carried out by reacting the resulting mixture with chlorine gas under light irradiation conditions. The process ensures continuous chlorination of aromatic rings and side chains of methylated aromatic compounds at a high yield without using any catalysts or perilous solvents such as carbon tetrachloride.

摘要翻译： 公开了一种在四氯化钛中氯化甲基化芳族化合物的方法。 环氯化首先通过使所述甲基化芳香族化合物与降低光照条件下的氯气反应进行，然后通过在光照射条件下使所得混合物与氯气反应来进行侧链氯化。 该方法确保甲基化芳族化合物的芳香环和侧链在不使用任何催化剂或危险溶剂如四氯化碳的情况下以高产率连续氯化。

公开(公告)号：US06916939B2

公开(公告)日：2005-07-12

申请号：US10344461

申请日：2001-08-08

申请人： Kazuyuki Yamane ,  Yukichika Kawakami ,  Hajime Hoshi ,  Kazuhiko Sunagawa

发明人： Kazuyuki Yamane ,  Yukichika Kawakami ,  Hajime Hoshi ,  Kazuhiko Sunagawa

IPC分类号： C07D319/12

CPC分类号： C08J3/28 ,  C07D319/12 ,  C08J11/24 ,  C08J2300/14 ,  C08J2367/04 ,  Y02W30/706

摘要： The present invention provides a process for production of a cyclic ester by depolymerization of an aliphatic polyester. In the process, a mixture containing the aliphatic polyester and a specific polyalkylene glycol ether, which has a boiling point of 230-450° C. and a molecular weight of 150-450, is heated under normal or reduced pressure to a temperature at which depolymerization of the aliphatic polyester takes place. Then, a substantially homogeneous solution phase, consisting of the melt phase of the aliphatic polyester and the liquid phase of the polyalkylene glycol ether, is formed. Heating of the solution phase is continued to form the cyclic ester by depolymerization and distil out the cyclic ester together with the polyalkylene glycol ether, and then the cyclic ester is recovered from the distillate. The present invention also provides a process for purification of a crude cyclic ester by use of the specific polyalkylene glycol ether described above.

摘要翻译： 本发明提供了通过脂肪族聚酯的解聚制备环状酯的方法。 在该方法中，将含有脂族聚酯和特定的聚亚烷基二醇醚的混合物在沸点为230-450℃，分子量为150-450的条件下，在正常或减压下加热至 发生脂肪族聚酯的解聚。 然后，形成由脂肪族聚酯的熔融相和聚亚烷基二醇醚的液相组成的基本均匀的溶液相。 溶液相的加热继续通过解聚形成环酯，并与聚亚烷基二醇醚一起蒸馏出环状酯，然后从馏出物中回收环状酯。 本发明还提供了通过使用上述特定的聚亚烷基二醇醚来纯化粗环酯的方法。

公开(公告)号：US5646291A

公开(公告)日：1997-07-08

申请号：US431573

申请日：1995-05-01

申请人： Hajime Hoshi ,  Kazuhiko Sunagawa ,  Takeo Watanabe

发明人： Hajime Hoshi ,  Kazuhiko Sunagawa ,  Takeo Watanabe

IPC分类号： C09B26/02 ,  C07D263/18

CPC分类号： C09B26/02

摘要： A process for manufacturing derivatives of 2-phenyl-4,5-oxazoledione 4-phenylhyrazone is disclosed. The process comprises reacting a derivative of a benezenediazonium salt, a hippuric acid derivative, and acetic anhydride in the presence of a neutralizing agent to effect the cyclization reaction for the formation of the oxazolone ring and the succeeding diazo-coupling reaction. The process does not require the conventional separate, independent step for the preparation of a solution of a hippuric acid derivative and acetic anhydride, thus eliminating the quick heating and quenching procedures and further avoiding the loss of the hippuric acid derivative due to decomposition of the oxazolone derivative. There is thus obtained a high yield of the desired product in a short period of time.

摘要翻译： 公开了一种制备2-苯基-4,5-恶唑二酮4-苯基腙的衍生物的方法。 该方法包括在中和剂存在下使衍生重氮盐，马尿酸衍生物和乙酸酐的衍生物进行反应，以进行恶唑酮环的形成和后续的重氮偶合反应的环化反应。 该方法不需要用于制备马尿酸衍生物和乙酸酐的常规独立的独立步骤，因此消除了快速加热和淬灭程序，并进一步避免了由于恶唑酮分解导致的马尿酸衍生物的损失 衍生物。 因此在短时间内获得了高产率的所需产物。

公开(公告)号：US07166750B1

公开(公告)日：2007-01-23

申请号：US10332471

申请日：2000-08-11

申请人： Kazuhiko Sunagawa ,  Hajime Hoshi ,  Shigeru Mizusawa ,  Nobuyuki Kusano ,  Satoru Kumazawa

发明人： Kazuhiko Sunagawa ,  Hajime Hoshi ,  Shigeru Mizusawa ,  Nobuyuki Kusano ,  Satoru Kumazawa

IPC分类号： C07C45/00 ,  C07C261/00 ,  C07C69/74

CPC分类号： C07C67/333 ,  C07C45/676 ,  C07C49/697 ,  C07C67/343 ,  C07C2601/08 ,  C07C69/757

摘要： 5-[(4-chlorophenyl)methyl]-2,2-dimethylcyclopentanone is produced by reacting 1-[(4-chlorophenyl)methyl]-3-methyl-2-oxocyclopentanecarboxylic acid methyl ester or 1-[(4-chlorophenyl)methyl]-3-methyl-2-oxocyclopentanecarboxylic acid ethyl ester with sodium hydride and methyl halide, then hydrolyzing the obtained 1-[(4-chlorophenyl)methyl]-3,3-dimethyl-2-oxocyclopentanecarboxylic acid methyl ester or 1-[(4-chlorophenyl)methyl]-3,3-dimethyl-2-oxocyclopentanecarboxylic acid ethyl ester. The process provides 5-[(4-chlorophenyl)methyl]-2,2-dimethylcyclopentanone, an important intermediate of an agricultural or horticultural fungicide, e.g., Metconazole.

摘要翻译： 5 - [（4-氯苯基）甲基] -2,2-二甲基环戊酮通过使1 - [（4-氯苯基）甲基] -3-甲基-2-氧代环戊烷甲酸甲酯或1 - [（4-氯苯基） 甲基] -3-甲基-2-氧代环戊烷甲酸乙酯与氢化钠和甲基卤反应，然后水解所得的1 - [（4-氯苯基）甲基] -3,3-二甲基-2-氧代环戊烷甲酸甲酯或1- [（4-氯苯基）甲基] -3,3-二甲基-2-氧代环戊烷甲酸乙酯。 该方法提供了5 - [（4-氯苯基）甲基] -2,2-二甲基环戊酮，农业或园艺杀真菌剂如甲基康唑的重要中间体。