公开(公告)号：US12110472B2

公开(公告)日：2024-10-08

申请号：US17292836

申请日：2018-11-13

Applicant: SYMRISE AG

Inventor： Bernd Hölscher ,  Vijayanand Chandrasekaran ,  Eva Ohrmann

IPC: C11B9/00 ,  C07C41/48 ,  C07C45/51 ,  C07C45/65 ,  C07C67/31 ,  C07C67/343

CPC classification number: C11B9/0034 ,  C07C41/48 ,  C07C45/515 ,  C07C45/65 ,  C07C67/31 ,  C07C67/343 ,  C07C2601/14 ,  C07C2601/16

Abstract: The present invention primarily relates to the use of 3-(4-isobutyl-2-methyl-cyclohexyl)pro-panal, 3-(4-Isobutyl-6-methyl-cyclohexa-1,5-dien-1-yl)propanal, 3-(4-isobutyl-6-meth-ylene-cyclohexen-1-yl)propanal, or 3-(4-isobutyl-6-methyl-cyclohexen-1-yl)propanal as perfuming ingredients. Moreover, the present invention relates to perfume compositions and perfumed products comprising the before mentioned perfuming ingredients. Still more particularly, the invention relates to a method for producing said perfumed products and a method of imparting and/or increasing i) floral and/or ii) green and/or iii) lily of the valley odor characteristics to perfumed products. This invention also relates to 3-(4-isobutyl-2-methyl-cyclohexyl)propanal, 3-(4-Isobutyl-6-methyl-cyclohexa-1,5-dien-1-yl)propanal, 3-(4-isobutyl-6-methylene-cyclohexen-1-yl)propanal, or 3-(4-isobutyl-6-methyl-cyclohexen-yl)propanal and a process for the preparation of said compounds.

公开(公告)号：US20240326030A1

公开(公告)日：2024-10-03

申请号：US18271800

申请日：2022-01-11

Applicant: David LEITCH ,  Jingjun hUANG ,  Matthew ISAAC ,  Ryan WATT ,  UVic Industry Partnerships Inc.

Inventor： David Leitch ,  Jingjun Huang ,  Matthew Isaac ,  Ryan Watt

IPC: B01J31/18 ,  B01J31/22 ,  B01J31/24 ,  C07C45/64 ,  C07C67/343 ,  C07C303/40 ,  C07D213/74 ,  C07D235/00 ,  C07D295/096

CPC classification number: B01J31/1815 ,  B01J31/2295 ,  B01J31/2409 ,  C07C45/64 ,  C07C67/343 ,  C07C303/40 ,  C07D213/74 ,  C07D235/00 ,  C07D295/096 ,  B01J2231/4261 ,  B01J2231/4283 ,  B01J2231/4288 ,  B01J2531/0241 ,  B01J2531/824

Abstract: Disclosed herein are embodiments of a Pd(0) precursor complex and embodiments of phosphorus-based Pd(0) catalysts formed therefrom. Also disclosed are method embodiments for making the Pd(0) precursor complex and the phosphorus-based Pd(0) catalysts. The Pd(0) precursor complex can be used to generate, in situ, the phosphorus-based Pd(0) catalysts, in various different types of palladium-mediated coupling reactions.

公开(公告)号：US11958802B2

公开(公告)日：2024-04-16

申请号：US17312274

申请日：2019-03-29

Applicant: Kawasaki Kasei Chemicals Ltd.

Inventor： Akihiko Yamada ,  Hidehiko Tanaka ,  Shigeaki Numata

IPC: C07C69/736 ,  C07C67/08 ,  C07C67/10 ,  C07C67/26 ,  C07C67/343 ,  C08F2/50

CPC classification number: C07C69/736 ,  C07C67/08 ,  C07C67/10 ,  C07C67/26 ,  C07C67/343 ,  C08F2/50 ,  C07C2603/24

Abstract: A photopolymerization sensitizer may not cause problems of dusting or coloring of a cured product due to bleeding of additives such as the photopolymerization sensitizer on the surface, e.g., by blooming at the time of photo-curing or during storage of the cured product, and which provides a practically sufficient photo-curing rate. A 9,10-bis(alkoxycarbonylalkyleneoxy)anthracene compound having ester groups, of formula (I):




wherein A is a C1-20 alkylene group, optionally branched by an alkyl group, R is a C1-20 alkyl group, optionally branched by the alkyl group, the C1-20 alkyl group optionally being a cycloalkyl group or a cycloalkylalkyl group, and X and Y are independently a hydrogen, a C1-8 alkyl group, or a halogen.

公开(公告)号：US20230202970A1

公开(公告)日：2023-06-29

申请号：US18177450

申请日：2023-03-02

Applicant: NiKang Therapeutic, Inc.

Inventor： Jiping FU ,  Yan LOU ,  Yigang HE ,  Yuetao SHI ,  Peng ZHOU ,  Xingxing LI

IPC: C07C253/30 ,  C07C45/27 ,  C07C29/00 ,  C07C29/143 ,  C07C67/307 ,  C07C45/00 ,  C07C67/343 ,  C07C45/66

CPC classification number: C07C253/30 ,  C07C45/27 ,  C07C29/00 ,  C07C29/143 ,  C07C67/307 ,  C07C45/002 ,  C07C67/343 ,  C07C45/66 ,  C07C2602/08 ,  C07C2603/10

Abstract: Disclosed herein are processes for preparing certain intermediates useful in the synthesis of 3-fluoro-5-(((1S,2aR)-1,3,3,4,4-pentafluoro-2a-hydroxy-2,2a,3,4-tetrahydro-1H-cyclopenta[cd]inden-7-yl)oxy)benzonitrile or a pharmaceutically acceptable salt thereof.

公开(公告)号：US09969671B2

公开(公告)日：2018-05-15

申请号：US15453414

申请日：2017-03-08

Applicant: SHIN-ETSU CHEMICAL CO., LTD.

Inventor： Yuki Miyake ,  Yusuke Nagae ,  Takeshi Kinsho

IPC: C07C67/10 ,  C07C67/32

CPC classification number: C07C67/32 ,  C07C67/343 ,  C07C69/24 ,  C07C69/34

Abstract: There is provided a method for producing ethyl 4-methyloctanoate at a lower cost, by fewer steps, and in higher yield. More specifically, there is provided a method for producing ethyl 4-methyloctanoate comprising the steps of: reacting 1-chloro-2-methylhexane through malonic ester synthesis to obtain diethyl 2-methylhexylmalonate, and subjecting the diethyl 2-methylhexylmalonate to a Krapcho reaction to obtain ethyl 4-methyloctanoate.

公开(公告)号：US20180118646A1

公开(公告)日：2018-05-03

申请号：US15797568

申请日：2017-10-30

Applicant: TOSOH CORPORATION ,  KYOTO UNIVERSITY

Inventor： Hisao EGUCHI ,  Takanori MIYAZAKI ,  Yoshiaki NAKAO

IPC: C07C41/30 ,  C07C1/32 ,  C07C17/263 ,  C07C67/28 ,  C07D213/16 ,  C07D295/033 ,  C07C45/61 ,  C07C303/30 ,  C07D213/64 ,  C07D215/06 ,  C07D217/04 ,  C07D409/04

CPC classification number: C07C41/30 ,  C07B37/04 ,  C07C1/321 ,  C07C1/323 ,  C07C17/263 ,  C07C41/18 ,  C07C45/45 ,  C07C45/49 ,  C07C45/59 ,  C07C45/61 ,  C07C67/28 ,  C07C67/343 ,  C07C303/30 ,  C07C315/04 ,  C07C2527/12 ,  C07C2603/24 ,  C07D213/16 ,  C07D213/64 ,  C07D215/06 ,  C07D217/04 ,  C07D295/033 ,  C07D409/04 ,  C07C43/205 ,  C07C43/225 ,  C07C15/14 ,  C07C15/24 ,  C07C15/28 ,  C07C22/08 ,  C07C25/13 ,  C07C69/78 ,  C07C69/94 ,  C07C47/575 ,  C07C49/78 ,  C07C317/14

Abstract: In a cross coupling reaction, in a case where a halogen atom is selected as the leaving group of the raw material compound, a harmful halogen waste forms as a by-product after the reaction, and disposal of the waste liquid is complicated and environmental burden is high. In a carbon-hydrogen activation cross coupling reaction which requires no halogen atom as the leaving group, although no halogen waste forms as a by-product, the reaction substrate is considerably restricted, and the reaction remains a limited molecular construction method.A method for producing an aromatic compound, which comprises subjecting an aromatic nitro compound and a boronic acid compound to a cross coupling reaction in the presence of a metal catalyst.

公开(公告)号：US09919993B2

公开(公告)日：2018-03-20

申请号：US15512316

申请日：2015-09-08

Applicant: EMCURE PHARMACEUTICALS LIMITED

Inventor： Mukund Keshav Gurjar ,  Shashikant Gangaram Joshi ,  Sachin Arvind Badhe ,  Mangesh Gorakhanath Kamble ,  Samit Satish Mehta

IPC: C07C51/16 ,  C07C51/09 ,  C07C45/48 ,  C07F9/54 ,  C07C67/56 ,  C07C67/52 ,  C07C67/00 ,  C07C67/343

CPC classification number: C07C51/09 ,  C07B2200/13 ,  C07C45/48 ,  C07C67/00 ,  C07C67/333 ,  C07C67/343 ,  C07C67/347 ,  C07C67/52 ,  C07C67/56 ,  C07F9/5456 ,  C07C59/64 ,  C07C69/716 ,  C07C69/738 ,  C07C69/734

Abstract: The present invention provides a process for preparation of {(2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethyl)phenyl-3,7-dimethyl-nona-2,4,6,8}tetraenoate, an acitretin intermediate of formula (VI) with trans isomer ≥97%, comprising of reacting 3-formyl-crotonic acid butyl ester of formula (V), substantially free of impurities, with 5-(4-methoxy-2,3,6-trimethylphenyl)-3-methyl-penta-2,4-diene-1-triphenyl phosphonium bromide of formula (IV) and isolating resultant compound of formula (VI), treating the filtrate with iodine for isomerization of the undesired cis intermediate and finally obtaining acitretin (I), with desired trans isomer ≥97%.

公开(公告)号：US09834523B2

公开(公告)日：2017-12-05

申请号：US15455691

申请日：2017-03-10

Applicant: E.I. DU PONT DE NEMOURS AND COMPANY

Inventor： Gary David Annis

IPC: C07D261/04 ,  C07C49/80 ,  C07C17/35 ,  C07C25/13 ,  C07C67/343 ,  C07C205/45 ,  C07C231/12 ,  C07D213/40 ,  C07D249/08 ,  C07D249/10 ,  C07D277/28 ,  C07C209/74 ,  C07C45/45 ,  C07C45/70 ,  C07C49/813 ,  C07C231/14 ,  C07D231/12 ,  C07D231/14 ,  C07D231/16

CPC classification number: C07D261/04 ,  C07C17/35 ,  C07C25/13 ,  C07C45/455 ,  C07C45/70 ,  C07C49/80 ,  C07C49/813 ,  C07C67/343 ,  C07C205/45 ,  C07C209/74 ,  C07C231/12 ,  C07C231/14 ,  C07C235/84 ,  C07D213/40 ,  C07D231/12 ,  C07D231/14 ,  C07D231/16 ,  C07D249/08 ,  C07D249/10 ,  C07D277/28 ,  C07C69/94 ,  C07C69/76 ,  C07C211/56

Abstract: Disclosed is a method for preparing a compound of Formula 1 wherein Q and Z are as defined in the disclosure comprising distilling water from a mixture comprising a compound of Formula 2, a compound of Formula 3, a base comprising at least one compound selected from the group consisting of alkaline earth metal hydroxides of Formula 4 wherein M is Ca, Sr or Ba, alkali metal carbonates of Formula 4a wherein M1 is Li, Na or K, 1,5-diazabicyclo[4.3.0]non-5-ene and 1,8-diazabicyclo[5.4.0]undec-7-ene, and an aprotic solvent capable of forming a low-boiling azeotrope with water. Also disclosed is a method for preparing a compound of Formula 2 comprising (1) forming a reaction mixture comprising a Grignard reagent derived from contacting a compound of Formula 5 wherein X is Cl, Br or I with magnesium metal or an alkylmagnesium halide in the presence of an ethereal solvent, and then (2) contacting the reaction mixture with a compound of Formula 6 wherein Y is OR11 or NR12R13, and R11, R12 and R13 are as defined in the disclosure. Further disclosed is a method for preparing a compound of Formula 7 wherein Q and Z are as defined in the disclosure, using a compound of Formula 1 characterized by preparing the compound of Formula 1 by the method disclosed above or using a compound of Formula 1 prepared by the method disclosed above.

公开(公告)号：US20170267628A1

公开(公告)日：2017-09-21

申请号：US15390111

申请日：2016-12-23

Applicant: Nano-C, Inc.

Inventor： Edward A. JACKSON ,  Henning RICHTER

IPC: C07C69/618 ,  C07C67/343 ,  C07C319/02

CPC classification number: C07C69/618 ,  C07C67/343 ,  C07C67/347 ,  C07C319/02 ,  C07C2104/00 ,  C07C2604/00

Abstract: [6,6]-Phenyl C71 butyric acid derivatives (C70-PCBR3) having a selectivity of greater than 95 wt % of the α-isomer are provided by reacting fullerene C70 with a dialkyl sulfonium tetrafluoroborate having the formula:

公开(公告)号：US20170233321A1

公开(公告)日：2017-08-17

申请号：US15586913

申请日：2017-05-04

Applicant: NISSAN CHEMICAL INDUSTRIES, LTD.

Inventor： Manabu YAOSAKA ,  Tomohisa UTSUNOMIYA ,  Yuji MORIYAMA ,  Tomohiro MATSUMOTO ,  Kazutaka MATOBA

IPC: C07C45/72 ,  C07C51/367 ,  C07C231/12 ,  C07D413/12 ,  C07C67/343 ,  C07D249/08 ,  C07D233/60 ,  C07D401/04 ,  C07D413/14 ,  C07D213/04

CPC classification number: C07C45/72 ,  C07C45/66 ,  C07C45/74 ,  C07C49/83 ,  C07C49/835 ,  C07C51/353 ,  C07C51/367 ,  C07C51/377 ,  C07C65/40 ,  C07C67/327 ,  C07C67/343 ,  C07C67/347 ,  C07C69/65 ,  C07C231/12 ,  C07C253/30 ,  C07C319/20 ,  C07D213/30 ,  C07D213/50 ,  C07D213/61 ,  C07D233/14 ,  C07D249/08 ,  C07D261/04 ,  C07D401/04 ,  C07C323/22 ,  C07C235/84 ,  C07C255/56 ,  C07C69/76 ,  C07C49/813 ,  C07C65/38

Abstract: There is provided a novel intermediate for producing pesticides. A method for producing the compound of Formula (3) comprises reacting an aromatic ketone compound of Formula (4) and a substituted acetophenone compound of Formula (5) as starting raw materials in an organic solvent or water in the presence or absence of an additive in the presence of a base in a suspended state. A method may comprise dehydrating the compound of Formula (3). A method for producing compound (2) in one step comprises reacting compound (4) and compound (5) to obtain compound (3). Further, a method for producing an isoxazoline compound of Formula (1) comprises reacting compound (2) and a hydroxylamine in an aliphatic or an aromatic hydrocarbon solvent which is optionally substituted by a halogen atom by adding an additive selected from a phase-transfer catalyst, a C1-C6 alcohol and an aprotic polar solvent in the presence of a base and water.