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7 条记录 (耗时 0.01 秒)

    Benzopyrans having an unsaturated side chain
    3.
    发明授权
    Benzopyrans having an unsaturated side chain 失效
    具有不饱和侧链的苯并吡喃

    公开(公告)号：US4036857A

    公开(公告)日：1977-07-19

    申请号：US654158

    申请日：1976-02-02

    申请人： Raj Kumar Razdan ,  Haldean Cloyce Dalzell

    发明人： Raj Kumar Razdan ,  Haldean Cloyce Dalzell

    IPC分类号： C07D311/80 ,  C07D307/83

    CPC分类号： C07D311/80

    摘要： 3-Formyl-6a,7,10,10a-tetrahydro-6,6,9-trimethyl-6H-dibenzo[b,d]pyran-1-ol, ethers and esters thereof having the formula ##STR1## wherein R is hydrogen, lower alkyl or lower alkanoyl and R.sub.6 is formyl or 1,3-dithiolan-2-yl but is 1,3-dithiolan-2-yl only when R is hydrogen, and derivatives thereof of the formula ##STR2## wherein R.sub.1 is hydrogen or lower alkanoyl, R.sub.2 is alkyl, aryl-lower alkyl or cycloalkyl-lower alkyl, A represents ##STR3## when R.sub.1 is hydrogen and R.sub.3 is lower alkyl, and A is ##STR4## when R.sub.1 is lower alkanoyl and R.sub.4 is the same lower alkanoyl represented by R.sub.1, processes of making such compounds and intermediates useful in such processes, pharmaceutical compositions containing the compounds and the use of the compounds as tranquilizing and antidepressant agents.

    摘要翻译： 3-甲酰基-6a，7,10,10a-四氢-6,6,9-三甲基-6H-二苯并[b，d]吡喃-1-醇，其具有式“IMAGE”的醚和酯，其中R是氢 ，低级烷基或低级烷酰基，R6为甲酰基或1,3-二硫戊环-2-基，但仅当R为氢时为1,3-二硫戊环-2-基，其衍生物为其中R 1为氢 或低级链烷酰基，R 2为烷基，芳基 - 低级烷基或环烷基 - 低级烷基，当R 1为氢且R 3为低级烷基时，A为，当R 1为低级烷酰基且A 4为低级烷酰基时，A为 由R1表示的烷酰基，制备此类化合物的方法和可用于此类方法的中间体，含有该化合物的药物组合物和该化合物作为镇定剂和抗抑郁剂的用途。

    Oxo C-ring benzopyrans
    4.
    发明授权
    Oxo C-ring benzopyrans 失效
    氧代C环苯并吡喃

    公开(公告)号：US4051152A

    公开(公告)日：1977-09-27

    申请号：US647050

    申请日：1976-01-07

    申请人： Raj Kumar Razdan ,  Haldean Cloyce Dalzell ,  Patricia Herlihy

    发明人： Raj Kumar Razdan ,  Haldean Cloyce Dalzell ,  Patricia Herlihy

    IPC分类号： A61K31/35 ,  A61K31/352 ,  A61P25/04 ,  A61P25/20 ,  C07D311/80 ,  C07D311/94 ,  C07D307/83

    CPC分类号： C07D311/94 ,  C07D311/80

    摘要： Benzopyrans of the formula ##STR1## wherein n represents 0 or 1, R is an alkyl group having 1 to 20 carbon atoms, an aryl-lower alkyl group or a cycloalkyl-lower alkyl group, R.sub.1 is hydrogen or ##STR2## wherein R.sub.4 is lower alkyl, phenyl, cycloalkyl-lower alkyl or aryl-lower alkyl, R.sub.2 is a lower alkyl and R.sub.3 is hydrogen or one or two lower alkyl groups, pharmaceutical compositions containing the compounds, and uses of the compounds as tranquilizers and analgesics.

    摘要翻译： 其中n表示0或1，R是具有1至20个碳原子的烷基，芳基 - 低级烷基或环烷基 - 低级烷基，R 1是氢或其中R 4是 低级烷基，苯基，环烷基 - 低级烷基或芳基 - 低级烷基，R2是低级烷基，R3是氢或一个或两个低级烷基，含有该化合物的药物组合物，以及该化合物作为镇定剂和止痛剂的用途。

    Alkyl substituted-4-oxo-cyclopenta benzopyrans
    6.
    发明授权
    Alkyl substituted-4-oxo-cyclopenta benzopyrans 失效
    烷基取代-4-氧代 - 环戊基苯并吡喃

    公开(公告)号：US4007207A

    公开(公告)日：1977-02-08

    申请号：US594534

    申请日：1975-07-09

    申请人： Martin Winn ,  Raj Kumar Razdan ,  Haldean Cloyce Dalzell ,  Joyce Ruth Krei

    发明人： Martin Winn ,  Raj Kumar Razdan ,  Haldean Cloyce Dalzell ,  Joyce Ruth Krei

    IPC分类号： C07D311/78

    CPC分类号： Y10S514/96

    摘要： 1,2,3,4-Tetrahydrocyclopenta[c][1]benzopyrans of the formulae ##STR1## wherein R is a lower alkyl group having 1 to 5 carbons, R.sub.1 is hydrogen or a lower alkyl group having 1 to 5 carbons, R.sub.2 is a lower alkyl group and R.sub.3 is an alkyl group having 1 to 20 carbon atoms, a phenyl-lower alkyl group or a cycloalkyl-lower alkyl group. The compounds have anti-hypertensive, antidepressant, analgesic, anticonvulsant, anti-anxiety, sedative-hypnotic and tranquilizing activity in animals.

    摘要翻译： 其中R为具有1至5个碳原子的低级烷基，R 1为氢或低级烷基，具有1至5个碳原子的低级烷基， 5个碳，R2为低级烷基，R3为碳原子数1〜20的烷基，苯基 - 低级烷基或环烷基 - 低级烷基。 该化合物在动物体内具有抗高血压，抗抑郁，镇痛，抗惊厥，抗焦虑，镇静催眠和镇静作用。

    Pharmaceutical compositions containing alryl substituted cyclopenta benzopyrans
    7.
    发明授权
    Pharmaceutical compositions containing alryl substituted cyclopenta benzopyrans 失效
    含有烯丙基取代的环戊基苯并吡喃的药物组合物

    公开(公告)号：US3992550A

    公开(公告)日：1976-11-16

    申请号：US594533

    申请日：1975-07-09

    申请人： Martin Winn ,  Raj Kumar Razdan ,  Haldean Cloyce Dalzell ,  Joyce Ruth Krei

    发明人： Martin Winn ,  Raj Kumar Razdan ,  Haldean Cloyce Dalzell ,  Joyce Ruth Krei

    IPC分类号： A61K31/335

    摘要： 1,2,3,4-Tetrahydrocyclopenta[c] [1]benzopyrans of the formulae ##SPC1##Wherein R is a lower alkyl group having 1 to 5 carbons, R.sub.1 is hydrogen or a lower alkyl group having 1 to 5 carbons, R.sub.2 is a lower alkyl group and R.sub.3 is an alkyl group having 1 to 20 carbon atoms, a phenyl-lower alkyl group or a cycloalkyl-lower alkyl group. The compounds have anti-hypertensive, antidepressant, analgesic, anticonvulsant, anti-anxiety and tranquilizing activity in animals.

    摘要翻译： 1,2,3,4-四氢环戊二烯并[c] [1]苯并吡喃，式为WHEREIN R为碳原子数1〜5的低级烷基，R1为氢或碳原子数为1〜5的低级烷基，R2为低级 烷基，R 3为碳原子数1〜20的烷基，苯基 - 低级烷基或环烷基 - 低级烷基。 该化合物在动物中具有抗高血压，抗抑郁，止痛，抗惊厥，抗焦虑和镇静作用。