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17 条记录 (耗时 0.022 秒)

    Oxo C-ring benzopyrans
    3.
    发明授权
    Oxo C-ring benzopyrans 失效
    氧代C环苯并吡喃

    公开(公告)号：US4051152A

    公开(公告)日：1977-09-27

    申请号：US647050

    申请日：1976-01-07

    申请人： Raj Kumar Razdan ,  Haldean Cloyce Dalzell ,  Patricia Herlihy

    发明人： Raj Kumar Razdan ,  Haldean Cloyce Dalzell ,  Patricia Herlihy

    IPC分类号： A61K31/35 ,  A61K31/352 ,  A61P25/04 ,  A61P25/20 ,  C07D311/80 ,  C07D311/94 ,  C07D307/83

    CPC分类号： C07D311/94 ,  C07D311/80

    摘要： Benzopyrans of the formula ##STR1## wherein n represents 0 or 1, R is an alkyl group having 1 to 20 carbon atoms, an aryl-lower alkyl group or a cycloalkyl-lower alkyl group, R.sub.1 is hydrogen or ##STR2## wherein R.sub.4 is lower alkyl, phenyl, cycloalkyl-lower alkyl or aryl-lower alkyl, R.sub.2 is a lower alkyl and R.sub.3 is hydrogen or one or two lower alkyl groups, pharmaceutical compositions containing the compounds, and uses of the compounds as tranquilizers and analgesics.

    摘要翻译： 其中n表示0或1，R是具有1至20个碳原子的烷基，芳基 - 低级烷基或环烷基 - 低级烷基，R 1是氢或其中R 4是 低级烷基，苯基，环烷基 - 低级烷基或芳基 - 低级烷基，R2是低级烷基，R3是氢或一个或两个低级烷基，含有该化合物的药物组合物，以及该化合物作为镇定剂和止痛剂的用途。

    Benzopyrans having an unsaturated side chain
    5.
    发明授权
    Benzopyrans having an unsaturated side chain 失效
    具有不饱和侧链的苯并吡喃

    公开(公告)号：US4036857A

    公开(公告)日：1977-07-19

    申请号：US654158

    申请日：1976-02-02

    申请人： Raj Kumar Razdan ,  Haldean Cloyce Dalzell

    发明人： Raj Kumar Razdan ,  Haldean Cloyce Dalzell

    IPC分类号： C07D311/80 ,  C07D307/83

    CPC分类号： C07D311/80

    摘要： 3-Formyl-6a,7,10,10a-tetrahydro-6,6,9-trimethyl-6H-dibenzo[b,d]pyran-1-ol, ethers and esters thereof having the formula ##STR1## wherein R is hydrogen, lower alkyl or lower alkanoyl and R.sub.6 is formyl or 1,3-dithiolan-2-yl but is 1,3-dithiolan-2-yl only when R is hydrogen, and derivatives thereof of the formula ##STR2## wherein R.sub.1 is hydrogen or lower alkanoyl, R.sub.2 is alkyl, aryl-lower alkyl or cycloalkyl-lower alkyl, A represents ##STR3## when R.sub.1 is hydrogen and R.sub.3 is lower alkyl, and A is ##STR4## when R.sub.1 is lower alkanoyl and R.sub.4 is the same lower alkanoyl represented by R.sub.1, processes of making such compounds and intermediates useful in such processes, pharmaceutical compositions containing the compounds and the use of the compounds as tranquilizing and antidepressant agents.

    摘要翻译： 3-甲酰基-6a，7,10,10a-四氢-6,6,9-三甲基-6H-二苯并[b，d]吡喃-1-醇，其具有式“IMAGE”的醚和酯，其中R是氢 ，低级烷基或低级烷酰基，R6为甲酰基或1,3-二硫戊环-2-基，但仅当R为氢时为1,3-二硫戊环-2-基，其衍生物为其中R 1为氢 或低级链烷酰基，R 2为烷基，芳基 - 低级烷基或环烷基 - 低级烷基，当R 1为氢且R 3为低级烷基时，A为，当R 1为低级烷酰基且A 4为低级烷酰基时，A为 由R1表示的烷酰基，制备此类化合物的方法和可用于此类方法的中间体，含有该化合物的药物组合物和该化合物作为镇定剂和抗抑郁剂的用途。

    Alkyl substituted-4-oxo-cyclopenta benzopyrans
    6.
    发明授权
    Alkyl substituted-4-oxo-cyclopenta benzopyrans 失效
    烷基取代-4-氧代 - 环戊基苯并吡喃

    公开(公告)号：US4007207A

    公开(公告)日：1977-02-08

    申请号：US594534

    申请日：1975-07-09

    申请人： Martin Winn ,  Raj Kumar Razdan ,  Haldean Cloyce Dalzell ,  Joyce Ruth Krei

    发明人： Martin Winn ,  Raj Kumar Razdan ,  Haldean Cloyce Dalzell ,  Joyce Ruth Krei

    IPC分类号： C07D311/78

    CPC分类号： Y10S514/96

    摘要： 1,2,3,4-Tetrahydrocyclopenta[c][1]benzopyrans of the formulae ##STR1## wherein R is a lower alkyl group having 1 to 5 carbons, R.sub.1 is hydrogen or a lower alkyl group having 1 to 5 carbons, R.sub.2 is a lower alkyl group and R.sub.3 is an alkyl group having 1 to 20 carbon atoms, a phenyl-lower alkyl group or a cycloalkyl-lower alkyl group. The compounds have anti-hypertensive, antidepressant, analgesic, anticonvulsant, anti-anxiety, sedative-hypnotic and tranquilizing activity in animals.

    摘要翻译： 其中R为具有1至5个碳原子的低级烷基，R 1为氢或低级烷基，具有1至5个碳原子的低级烷基， 5个碳，R2为低级烷基，R3为碳原子数1〜20的烷基，苯基 - 低级烷基或环烷基 - 低级烷基。 该化合物在动物体内具有抗高血压，抗抑郁，镇痛，抗惊厥，抗焦虑，镇静催眠和镇静作用。

    Pharmaceutical compositions containing alryl substituted cyclopenta benzopyrans
    7.
    发明授权
    Pharmaceutical compositions containing alryl substituted cyclopenta benzopyrans 失效
    含有烯丙基取代的环戊基苯并吡喃的药物组合物

    公开(公告)号：US3992550A

    公开(公告)日：1976-11-16

    申请号：US594533

    申请日：1975-07-09

    申请人： Martin Winn ,  Raj Kumar Razdan ,  Haldean Cloyce Dalzell ,  Joyce Ruth Krei

    发明人： Martin Winn ,  Raj Kumar Razdan ,  Haldean Cloyce Dalzell ,  Joyce Ruth Krei

    IPC分类号： A61K31/335

    摘要： 1,2,3,4-Tetrahydrocyclopenta[c] [1]benzopyrans of the formulae ##SPC1##Wherein R is a lower alkyl group having 1 to 5 carbons, R.sub.1 is hydrogen or a lower alkyl group having 1 to 5 carbons, R.sub.2 is a lower alkyl group and R.sub.3 is an alkyl group having 1 to 20 carbon atoms, a phenyl-lower alkyl group or a cycloalkyl-lower alkyl group. The compounds have anti-hypertensive, antidepressant, analgesic, anticonvulsant, anti-anxiety and tranquilizing activity in animals.

    摘要翻译： 1,2,3,4-四氢环戊二烯并[c] [1]苯并吡喃，式为WHEREIN R为碳原子数1〜5的低级烷基，R1为氢或碳原子数为1〜5的低级烷基，R2为低级 烷基，R 3为碳原子数1〜20的烷基，苯基 - 低级烷基或环烷基 - 低级烷基。 该化合物在动物中具有抗高血压，抗抑郁，止痛，抗惊厥，抗焦虑和镇静作用。

    Benzopyrano[3,4-d]pyridine-2-cyano, carboxamidoximes and carboximidates
    8.
    发明授权
    Benzopyrano[3,4-d]pyridine-2-cyano, carboxamidoximes and carboximidates 失效
    苯并吡喃并[8,3-d {9吡啶-2-氰基，甲酰氨基肟和羰基亚氨酸酯

    公开(公告)号：US4096265A

    公开(公告)日：1978-06-20

    申请号：US739546

    申请日：1976-11-08

    申请人： Anil Chandra Ghosh ,  Raj Kumar Razdan

    发明人： Anil Chandra Ghosh ,  Raj Kumar Razdan

    IPC分类号： C07D491/04 ,  C07D491/052 ,  A61K31/44

    CPC分类号： C07D491/04 ,  Y10S514/929

    摘要： Benzopyrano[3,4-d]pyridine-2-cyano, carboxamidoximes and carboximidates of the formula ##STR1## wherein R represents -C.ident.N, ##STR2## R.sub.1 is a lower alkyl, R.sub.2 is hydrogen or a lower alkyl and R.sub.3 is a straight or branched alkyl having 1 to 20 carbons, a cycloalkyl-lower alkyl group in which the cycloalkyl group has 3 to 8 carbons or it is an arylalkyl group, and R.sub.4 is a lower alkyl group.The compounds are useful for lowering blood pressure.

    摘要翻译： 苯并吡喃并[3,4-d]吡啶-2-氰基，甲酰氨基肟和式ⅩⅧ的肟基，其中R表示-C = N，R 1是低级烷基，R 2是氢或低级烷基，R 3是 碳原子数为1〜20的直链或支链烷基，环烷基为碳原子数为3〜8的环烷基 - 低级烷基或芳基烷基，R4为低级烷基。

    Resorcinol amine derivatives
    9.
    发明授权
    Resorcinol amine derivatives 失效
    间苯二酚胺衍生物

    公开(公告)号：US3951970A

    公开(公告)日：1976-04-20

    申请号：US402481

    申请日：1973-10-01

    申请人： Raj Kumar Razdan ,  Harry George Pars

    发明人： Raj Kumar Razdan ,  Harry George Pars

    IPC分类号： C07D295/096 ,  C07D295/08

    CPC分类号： C07D295/096

    摘要： Compounds of the formula ##SPC1##And acid addition salts thereof, wherein R represents an alkyl group having 1 to 20 carbon atoms, an arylalkyl group, or a cycloalkyl-lower alkyl group, R.sub.1 and R.sub.2 represent hydrogen or the same or different lower alkyl or lower alkanoyl groups; and Z represents --NH.sub.2, --NHR.sub.3, --NR.sub.3 R.sub.4, or ##EQU1## WHERE R.sub.3 is lower alkyl, or phenyl-lower alkyl, R.sub.4 is lower alkyl or phenyl-lower alkyl, m is an integer from 0 to 6, n is an integer from 0 to 6, m + n is an integer from 3 to 6, and X is CH.sub.2, CHR.sub.3, O, S, or NR.sub.3.The compounds have pharmacological activity, including antidepressant and anti-hypertensive activity, in animals.

    摘要翻译： 式的化合物及其酸加成盐，其中R表示碳原子数1〜20的烷基，芳烷基或环烷基 - 低级烷基，R 1和R 2表示氢或相同或不同的低级烷基或低级烷酰基 团体 Z表示-NH 2，-NHR 3，-NR 3 R 4或（CH 2）n -NX（CH 2）m，其中R 3为低级烷基或苯基 - 低级烷基，R 4为低级烷基或苯基 - 低级烷基，m为 0〜6，n为0〜6的整数，m + n为3〜6的整数，X为CH 2，CHR 3，O，S或NR 3。

    Heterocyclic esters of benzopyrans
    10.
    发明授权
    Heterocyclic esters of benzopyrans 失效
    苯并吡喃的杂环酯

    公开(公告)号：US3941782A

    公开(公告)日：1976-03-02

    申请号：US361897

    申请日：1973-05-21

    申请人： Louis Selig Harris ,  Harry George Pars ,  Raj Kumar Razdan ,  John Clark Sheehan

    发明人： Louis Selig Harris ,  Harry George Pars ,  Raj Kumar Razdan ,  John Clark Sheehan

    IPC分类号： C07D295/15 ,  C07D311/80 ,  C07D311/94 ,  C07D311/78

    CPC分类号： C07D295/15 ,  C07D311/80 ,  C07D311/94

    摘要： This invention relates to novel esters of benzopyrans represented by the formulae ##SPC1##Wherein R and R' are hydrogen or C.sub.1 -C.sub.6 alkyl and when alkyl are on the same or different carbons; R.sub.1 is C.sub.1 -C.sub.6 alkyl; R.sub.2 is C.sub.1 -C.sub.20 alkyl, lowercycloalkyloweralkyl or lowercycloalkyl; n is an integer from 3 to 7, and particularly 3 to 5; Y is a straight or branched chain C.sub.1 -C.sub.8 alkylene; and R.sub.3 is ##EQU1## WHEREIN A IS AN INTEGER FROM 1 TO 4, B IS AN INTEGER FROM 1 TO 4, X is O,S, CH.sub.2 or NR.sub.4 and R.sub.4 is hydrogen C.sub.1 -C.sub.6 alkyl, and R.sub.5 is hydrogen or C.sub.1 -C.sub.6 alkyl; and the acid addition salts thereof. The compounds exhibit analgesic and central nervous system activity.

    摘要翻译： 本发明涉及由式WHEREIN R和R'表示的苯并吡喃的新型酯是氢或C 1 -C 6烷基，当烷基在相同或不同的碳上时; R1是C1-C6烷基; R2是C1-C20烷基，低级环烷基低级烷基或低级环烷基; n为3〜7的整数，特别是3〜5的整数。 Y是直链或支链C1-C8亚烷基; 并且R 3是（CH 2）a R 5 | -N角度X（CH 2）b，其中A是从1到4的整数，B是从1到4的整数，X是O，S，CH 2或NR 4，并且R 4是氢C1 -C6烷基，R5为氢或C1-C6烷基; 及其酸加成盐。 该化合物显示镇痛和中枢神经系统活性。