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1.发明授权
公开(公告)号：US4710496A
公开(公告)日：1987-12-01
申请号：US753278
申请日：1985-07-09
申请人： Karl-Heinz Geiss , Bernhard Schmied , Manfred Raschack , Hans-Dieter Lehmann , Josef Gries , Klaus Ruebsamen
发明人： Karl-Heinz Geiss , Bernhard Schmied , Manfred Raschack , Hans-Dieter Lehmann , Josef Gries , Klaus Ruebsamen
IPC分类号： A61K31/50 , A61K31/55 , A61P1/04 , A61P7/02 , A61P9/04 , A61P9/12 , C07D237/00 , C07D403/04 , C07D403/10 , C07D401/14 , C07D403/14
CPC分类号： C07D403/04 , C07D403/10
摘要： Novel pyrrol-1-ylphenyldihydropyridazinones of the formula ##STR1## their preparation and their use in the treatment of disorders.
摘要翻译： 具有下式的新型吡咯-1-基苯基二氢哒嗪酮其制备方法及其在治疗疾病中的应用。
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公开(公告)号：US4303521A
公开(公告)日：1981-12-01
申请号：US161020
申请日：1980-06-19
申请人： Hans-Dieter Lehmann
发明人： Hans-Dieter Lehmann
CPC分类号： A61M1/1696
摘要： Columns for the treatment of a liquid with particulate material are disclosed comprising first and second layers of sheet material in face-to-face contact with each other, an inlet and an outlet located at points between the layers, and welds or the like for joining the layers together along a pair of substantially parallel paths between the inlet and the outlet in order to form an elongated space adapted to be filled with particulate material therebetween. In a preferred embodiment, the aforesaid column comprises a first column portion, and the column includes a second column portion which also includes layers of sheet material in face-to-face contact with each other, an inlet, an outlet, welds for joining the two layers of sheet material together along a pair of substantially parallel paths between the inlet and the outlet so as to form an elongated space adapted to be filled with the particulate material therebetween, and a tubular connector for connecting the outlet from the first column portion with the inlet to the second column portion so that liquid may be fed from the inlet to the first column portion through both column portions to the outlet from the second column portion for contact with the particulate material in both column portions.
摘要翻译： 公开了用于处理具有颗粒材料的液体的柱，其包括彼此面对面接触的第一和第二层片材，位于层之间的入口和出口，以及用于接合的焊缝等 这些层沿入口和出口之间的一对基本上平行的路径一起形成，以便形成适于在其间填充颗粒材料的细长空间。 在优选实施例中，上述柱包括第一柱部分，并且柱包括第二柱部分，第二柱部分还包括彼此面对面接触的片材层，入口，出口，用于接合 两层片材沿着入口和出口之间的一对基本上平行的路径一起形成，以形成适于在其间填充颗粒材料的细长空间;以及管状连接器，用于将来自第一柱部分的出口与 第二塔部分的入口，使得液体可以从入口到第一塔部分通过两个塔部分供给到来自第二塔部分的出口，用于与两个塔部分中的颗粒材料接触。
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公开(公告)号：US08309520B2
公开(公告)日：2012-11-13
申请号：US12952629
申请日：2010-11-23
申请人： Hans-Dieter Lehmann
发明人： Hans-Dieter Lehmann
CPC分类号： C07K14/765 , A61K47/60 , A61L27/34 , A61L29/085 , A61L33/12
摘要： The present invention relates to a fully synthetic albumin analog, to a hemocompatible coating for medical devices containing the fully synthetic albumin analog, as well as to medical devices coated with the hemocompatible coating. The albumin analog preferably has two basic structures which are connected with one another via at least one bridging unit, the basic structures respectively having, in a geometrically defined manner, at least two bound joint regions to which at least one residue is covalently bound, wherein the basic structures are, respectively, a benzene carboxylic acid, and wherein the joint regions are formed via acid amide bonds, and wherein each residue, respectively, comprises a lipophilic region and a hydrophilic region.
摘要翻译： 本发明涉及完全合成的白蛋白类似物，涉及含有全合成白蛋白类似物的医疗装置的血液相容性涂层，以及涂覆有血液相容性涂层的医疗器械。 所述白蛋白类似物优选具有通过至少一个桥接单元相互连接的两个基本结构，所述碱性结构分别具有至少两个结合的接合区域，至少两个结合的接合区域至少一个残基被共价键合到其上，其中 碱性结构分别为苯羧酸，其中通过酰胺键形成接合区，其中各残基分别包含亲油性区和亲水区。
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4.发明授权Process and device for the removal of waste metabolites from a solution containing such metabolites 失效从含有此类代谢物的溶液中除去废代谢物的方法和装置
公开(公告)号：US4313831A
公开(公告)日：1982-02-02
申请号：US104446
申请日：1979-12-17
CPC分类号： A61M1/1696 , B01D15/00
摘要： Processes and apparatus for the removal of waste metabolites from metabolite-containing solutions are disclosed. The disclosed processes include alternatively adsorbing and desorbing the metabolites on a pair of adsorbent-containing columns, each column being maintained at a reduced temperature during adsorption and at an elevated temperature during desorption, with the columns being flushed subsequent to desorption and prior to their re-use for adsorption thereon. The disclosed apparatus includes a pair of adsorbent-containing columns, means for alternatively delivering the metabolite containing solution to each of the columns for alternate adsorption and desorption thereon, means for withdrawing the metabolite containing solution from each of the columns, means for alternately flushing the columns subsequent to desorption and prior to adsorption thereon, and means for alternately maintaining the columns at reduced temperatures during adsorption and at elevated temperatures during desorption so that the effectiveness of the adsorbent for adsorption is increased during adsorption at the reduced temperatures.A disposable tube set for use in connection with such a pair of adsorbent containing columns is also disclosed, including a flexible inlet tube including a pair of inlet branches for delivery of the metabolite containing solution to each of the columns, and a flexible outlet tube including a pair of outlet tube branches for connection with the outlet end of each of the columns.
摘要翻译： 公开了从含代谢物的溶液中除去废代谢物的方法和设备。 所公开的方法包括替代地将代谢物吸附和解吸附在一对含吸附剂的柱上，每个塔在吸附过程中保持在降低的温度，并且在解吸期间在升高的温度下保持在降低的温度，同时在解吸附之后并在其再次 - 用于吸附。 所公开的装置包括一对含吸附剂的柱，用于将含有代谢物的溶液交替地输送到每个柱以用于在其上进行交替吸附和解吸的装置，用于从每个柱抽出含代谢物的溶液的装置，用于交替地将 在脱附之后和吸附之前的塔，以及用于在解吸期间在吸附期间和升高的温度下交替地将塔保持在降低的温度的装置，使得在降低的温度下吸附期间吸附剂的吸附效果增加。 还公开了一种用于与这种一对含吸附剂的柱结合使用的一次性管组，其包括柔性入口管，其包括用于将含代谢物溶液递送到每个柱的一对入口支管，以及柔性出口管，其包括 一对出口管分支，用于与每个柱的出口端连接。
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5.发明授权
公开(公告)号：US4250141A
公开(公告)日：1981-02-10
申请号：US969847
申请日：1978-12-15
CPC分类号： A61M1/3679 , B01D15/00
摘要： A column for removing poisons and/or other undesired substances from a liquid mixture. The column has a mixture of inactive filler particles and active granules positioned therein, with said filler particles being substantially larger than said active granules, (which are selected from adsorbing material and ion-exchanging material). The filler particles are in fixed contact relationship with each other and the active granules completely fill the spaces between the filler particles.
摘要翻译： 用于从液体混合物中除去毒物和/或其他不需要物质的柱。 该柱具有位于其中的惰性填料颗粒和活性颗粒的混合物，所述填料颗粒基本上大于所述活性颗粒（其选自吸附材料和离子交换材料）。 填料颗粒彼此处于固定的接触关系，活性颗粒完全填充填料颗粒之间的空间。
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公开(公告)号：US4863603A
公开(公告)日：1989-09-05
申请号：US176669
申请日：1988-04-01
CPC分类号： B01D69/12 , A61M1/3472 , A61M1/3475 , A61M1/3482 , B01D61/18 , B01D63/14 , A61M1/3675 , A61M1/3679
摘要： A multilayer filter medium (6) is used for separating precipitates containing cholesterol from blood plasma which consists of at least one open filter medium (7) which adsorbs precipitate and of a microporous membrane (9) which controls the pressure conditions in the filter element, whereby the layer (7) which specifically adsorbs the precipitate is hydrophobic and the microporous membrane (9) is hydrophilic. In addition, a positively charged adsorption medium (9) is provided on the side of the microporous membrane (8) facing away from the hydrophobic adsorption medium (7). In this manner, a large adsorption area is created and kept accessible for the precipitates and for heparin.
摘要翻译： 使用多层过滤介质（6）从血浆中分离含有胆固醇的沉淀物，其由吸附沉淀物的至少一个开放过滤介质（7）和控制过滤元件压力条件的微孔膜（9）组成， 从而特异性吸附沉淀物的层（7）是疏水性的，微多孔膜（9）是亲水性的。 此外，在远离疏水性吸附介质（7）的微孔膜（8）侧设置带正电荷的吸附介质（9）。 以这种方式，产生大的吸附区域并且使其能够被沉淀物和肝素所接近。
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7.发明授权
公开(公告)号：US4636504A
公开(公告)日：1987-01-13
申请号：US571675
申请日：1984-01-17
申请人： Phillip A. Rossy , Marco Thyes , Albrecht Franke , Horst Koenig , Hans Dieter Lehmann , Josef Gries , Ludwig Friedrich , Dieter Lenke
发明人： Phillip A. Rossy , Marco Thyes , Albrecht Franke , Horst Koenig , Hans Dieter Lehmann , Josef Gries , Ludwig Friedrich , Dieter Lenke
IPC分类号： A61K31/50 , A61K31/502 , A61K31/535 , A61K31/55 , A61P1/04 , A61P7/02 , A61P9/12 , C07D237/04 , C07D237/14 , C07D237/26 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D417/14 , C07D521/00 , C07D237/06
CPC分类号： C07D231/12 , C07D233/56 , C07D237/04 , C07D237/14 , C07D237/26 , C07D249/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D413/12
摘要： Novel 6-(acylaminoaryl)-3(2H)-pyridazinones of the formula ##STR1## where R.sup.1, R.sup.2, R.sup.3, R.sup.4, A and B have the meanings given in the description, and their preparation are described and inhibiting thrombocyte aggregation and gastric secretion.The compounds are useful for treating disorders.
摘要翻译： 式（Ⅰ）的新型6-（酰基氨基芳基）-3（2H） - 哒嗪酮其中R 1，R 2，R 3，R 4，A和B具有说明书中给出的含义及其制备，并描述并抑制血小板 聚集和胃分泌。 该化合物可用于治疗疾病。
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8.发明授权Method of binding a biologically active material to a carrier containing hydroxyl groups 失效将生物活性物质与含有羟基的载体结合的方法
公开(公告)号：US4412000A
公开(公告)日：1983-10-25
申请号：US320215
申请日：1981-11-12
CPC分类号： C08G18/6446 , C12N11/02
摘要： Biologically active material such as an enzyme is bonded to a carrier containing hydroxyl groups by binding an isocyanate compound to the carrier and bonding the biologically active material to the bound isocyanate compound. Binding of the isocyanate compound to the carrier is achieved with the use of a non-toxic titanium based compound which catalyzes the formation of urethane bonds. The preferred non-toxic based titanium compound is an orthotitanium acid ester such as tetrabutyltitanate.
摘要翻译： 生物活性物质如酶通过将异氰酸酯化合物与载体结合并将生物活性物质结合到结合的异氰酸酯化合物上而与含有羟基的载体结合。 异氰酸酯化合物与载体的结合是通过使用催化形成氨基甲酸酯键的无毒的钛基化合物实现的。 优选的无毒基钛化合物是正钛酸酯如四丁基钛酸酯。
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公开(公告)号：US20110117139A1
公开(公告)日：2011-05-19
申请号：US12952629
申请日：2010-11-23
申请人： Hans-Dieter Lehmann
发明人： Hans-Dieter Lehmann
CPC分类号： C07K14/765 , A61K47/60 , A61L27/34 , A61L29/085 , A61L33/12
摘要： The present invention relates to a fully synthetic albumin analog, to a hemocompatible coating for medical devices containing the fully synthetic albumin analog, as well as to medical devices coated with the hemocompatible coating. The albumin analog preferably has two basic structures which are connected with one another via at least one bridging unit, the basic structures respectively having, in a geometrically defined manner, at least two bound joint regions to which at least one residue is covalently bound, wherein the basic structures are, respectively, a benzene carboxylic acid, and wherein the joint regions are formed via acid amide bonds, and wherein each residue, respectively, comprises a lipophilic region and a hydrophilic region.
摘要翻译： 本发明涉及完全合成的白蛋白类似物，涉及含有全合成白蛋白类似物的医疗装置的血液相容性涂层，以及涂覆有血液相容性涂层的医疗器械。 所述白蛋白类似物优选具有通过至少一个桥接单元相互连接的两个基本结构，所述碱性结构分别具有至少两个结合的接合区域，至少两个结合的接合区域至少一个残基被共价键合到其上，其中 碱性结构分别为苯羧酸，其中通过酰胺键形成接合区，其中各残基分别包含亲油性区和亲水区。
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公开(公告)号：US4376707A
公开(公告)日：1983-03-15
申请号：US243968
申请日：1979-05-21
申请人： Hans-Dieter Lehmann
发明人： Hans-Dieter Lehmann
CPC分类号： A61M1/1696 , A61M1/3687 , B01D15/00
摘要： A process is disclosed for removing urea from blood wash fluids or blood fluids in which the fluids are treated with an organic solid containing at least one proton-containing secondary substituent group which masks and activates the aldehyde group and the fluids and the solid organic compound are separated.
摘要翻译： 公开了一种从血液洗涤液或血液中除去尿素的方法，其中流体用含有至少一个含有质子的第二取代基的有机固体进行处理，所述第二取代基掩盖并活化醛基，而液体和固体有机化合物是 分开
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