Sodium salt of (6S)-folinic acid
    1.
    发明授权
    Sodium salt of (6S)-folinic acid 失效
    (6S) - 醋酸的钠盐

    公开(公告)号:US6160116A

    公开(公告)日:2000-12-12

    申请号:US459692

    申请日:1995-06-02

    IPC分类号: C07D475/04

    CPC分类号: C07D475/04

    摘要: The invention relates to a process for preparing (6S)-folinic acid and its salts by recrystallization of alkaline-earth salts of (6R,S)-folinic acid and, where necessary, liberation of the acid from the alkaline-earth folinates and/or, where necessary, conversion into the alkali salts by at least one recrystallization in the presence of a base. The invention also relates to calcium-, magnesium-, potassium- and sodium-(6S)-folinates and to (6S)-folinic acid prepared in accordance with the invention.

    摘要翻译: 本发明涉及一种通过(6R,S) - 赖氨酸的碱土金属盐的重结晶和必要时从碱土金属叶酸和/或碱土金属盐释放酸来制备(6S) - 丝氨酸及其盐的方法, 或者如果需要,在碱的存在下通过至少一次重结晶转化成碱金属盐。 本发明还涉及根据本发明制备的钙,镁,钾和钠 - (6S) - 叶酸和(6S) - 丝氨酸。

    Method of preparing 4-methyl-5-hydroxymethyl-imidazole
    2.
    发明授权
    Method of preparing 4-methyl-5-hydroxymethyl-imidazole 失效
    制备4-甲基-5-羟甲基咪唑的方法

    公开(公告)号:US4189591A

    公开(公告)日:1980-02-19

    申请号:US6533

    申请日:1979-01-25

    IPC分类号: C07D233/54 C07D233/64

    CPC分类号: C07D233/64

    摘要: The yield of 4-methyl-5-hydroxymethyl-imidazole from the known reaction between formaldehyde and 4-methyl-imidazole can be increased greatly if the reaction is performed in a concentrated aqueous medium at pH 11-13.5, preferably 12-13.5, at a temperature of 20.degree.-60.degree. C., preferably 30.degree.-40.degree. C., with an amount of formaldehyde not exceeding 1.5 mole per mole of 4-methyl-imidazole.

    摘要翻译: 如果反应在pH 11-13.5,优选12-13.5的浓缩水性介质中进行,甲醛和4-甲基 - 咪唑之间已知反应的4-甲基-5-羟甲基咪唑的产率可大大提高 温度为20°-60℃,优选30°-40℃,甲醛量不超过1.5摩尔/摩尔4-甲基 - 咪唑。

    Process for preparing purine compounds
    4.
    发明授权
    Process for preparing purine compounds 失效
    嘌呤化合物的制备方法

    公开(公告)号:US4602089A

    公开(公告)日:1986-07-22

    申请号:US582229

    申请日:1984-02-21

    CPC分类号: C07D473/00 C07D233/90

    摘要: There are prepared compounds of the formulae ##STR1## where R is lower alkyl, chlorine, or bromine and n is an integer from 1 to 5. The compounds of formula (1) can be used to make erythro-9-(2-hydroxy-3-nonyl) hypoxanthine and its homologues and also to make the compounds of formulae (2) and (3). All three classes of compounds are useful as immunomodulators.

    摘要翻译: 制备式为“IMAGE”(1.)(2.)或(3.)的化合物,其中R为低级烷基,氯或溴,n为1至5的整数。 式(1)化合物可用于制备赤-9(2-羟基-3-壬基)次黄嘌呤及其同系物,并制备式(2)和(3)的化合物。 所有三类化合物都可用作免疫调节剂。

    Imidazole compounds
    5.
    发明授权
    Imidazole compounds 失效
    咪唑化合物

    公开(公告)号:US4451478A

    公开(公告)日:1984-05-29

    申请号:US357679

    申请日:1982-03-12

    CPC分类号: C07D473/00 C07D233/90

    摘要: There are prepared compounds of the formulae ##STR1## where R is lower alkyl, chlorine, or bromine and n is an integer from 1 to 5. The compounds of formula (1) can be used to make erythro-9-(2-hydroxy-3-nonyl) hypoxanthine and its homologues and also to make the compounds of formulae (2) and (3). All three classes of compounds are useful as immunomodulators.

    摘要翻译: 制备式为“IMAGE”(1.)(2.)或(3.)的化合物,其中R为低级烷基,氯或溴,n为1至5的整数。 式(1)化合物可用于制备赤-9(2-羟基-3-壬基)次黄嘌呤及其同系物,并制备式(2)和(3)的化合物。 所有三类化合物都可用作免疫调节剂。