-
1.发明授权Amino alcohol-substituted arylthienopyrimidinones, process for their preparation and their use as medicaments 有权氨基醇取代的芳基噻吩并嘧啶酮，其制备方法及其用作药物公开(公告)号：US08853208B2
公开(公告)日：2014-10-07
申请号：US12191678
申请日：2008-08-14
申请人： Lothar Schwink , Siegfried Stengelin , Matthias Gossel , Gerhard Hessler , Torsten Haack , Petra Lennig
发明人： Lothar Schwink , Siegfried Stengelin , Matthias Gossel , Gerhard Hessler , Torsten Haack , Petra Lennig
IPC分类号： C07D495/04 , A61K31/519 , C07D519/00 , A61P3/10 , A61P3/04
CPC分类号： C07D495/04 , C07D519/00
摘要： The invention relates to amino alcohol-substituted arylthienopyrimidinones having a formula I and their derivatives, and their physiologically tolerated salts and physiologically functional derivatives, their preparation, medicaments comprising at least one amino alcohol-substituted arylthienopyrimidinone of the invention or its derivative, and the use of the amino alcohol-substituted arylthienopyrimidinones of the invention and their derivatives as MCH antagonists.
摘要翻译： 本发明涉及具有式I及其衍生物的氨基醇取代的芳基噻吩并嘧啶酮及其生理上耐受的盐和生理功能衍生物，其制备方法，包含本发明的至少一种氨基醇取代的芳基噻吩并嘧啶酮或其衍生物的药物及其用途 的本发明的氨基醇取代的芳基噻吩并嘧啶酮及其衍生物作为MCH拮抗剂。
-
2.发明申请公开(公告)号：US20140100156A1
公开(公告)日：2014-04-10
申请号：US14049597
申请日：2013-10-09
申请人： Torsten HAACK , Michael WAGNER , Bernd HENKEL , Siegfried STENGELIN , Andreas EVERS , Martin BOSSART
发明人： Torsten HAACK , Michael WAGNER , Bernd HENKEL , Siegfried STENGELIN , Andreas EVERS , Martin BOSSART
IPC分类号： C07K14/605 , A61K38/28 , A61K45/06 , A61K38/26
CPC分类号： A61K38/26 , A61K38/00 , A61K38/2264 , A61K38/28 , A61K45/06 , C07K14/605 , Y02A50/401 , A61K2300/00
摘要： The present invention relates to exendin-4 derivatives and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, as well as reduction of excess food intake.
摘要翻译： 本发明涉及毒蜥外泌肽-4衍生物及其医疗用途，例如用于治疗代谢综合征疾病，包括糖尿病和肥胖症，以及减少过量的食物摄入。
-
3.发明授权公开(公告)号：US08609731B2
公开(公告)日：2013-12-17
申请号：US12705140
申请日：2010-02-12
IPC分类号： A61K31/40 , A61K31/165 , C07C233/04 , C07C233/06
CPC分类号： C07D405/12 , A61K31/397 , A61K31/4025 , A61K31/4525 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/553 , A61K45/06 , C07D307/12
摘要： The invention relates to substituted tetrahydronaphthalenes and derivatives thereof, and also to the physiologically compatible salts and physiologically functional derivatives thereof, to preparation thereof, to medicaments comprising at least one inventive substituted tetrahydronaphthalene or derivative thereof, and to the use of the inventive substituted tetrahydronaphthalenes and derivatives thereof as medicaments.
摘要翻译： 本发明涉及取代的四氢萘及其衍生物，以及其生理上相容的盐和生理功能衍生物及其制备方法，涉及包含至少一种本发明取代的四氢化萘或其衍生物的药物，以及本发明取代的四氢萘和 其衍生物作为药物。
-
公开(公告)号：US08357686B2
公开(公告)日：2013-01-22
申请号：US12489653
申请日：2009-06-23
IPC分类号： A61K31/4985 , A61K31/435 , A61K31/46 , A61K31/454 , C07D455/02 , C07D451/02 , C07D403/12 , C07D487/04 , C07D401/14 , C07D405/14 , A61P3/04
CPC分类号： C07D471/04 , C07D471/08 , C07D487/04
摘要： The invention relates to aryl-substituted polycyclic amines of the formula I, especially bicyclic amines, and to the physiologically tolerated salts and physiologically functional derivatives thereof; where the symbols and radicals are explained in the description as well as to pharmaceutical compositions and medical treatments employing these compounds.
-
5.发明授权Substituted N-phenyl-pyrrolidinylmethylpyrrolidine amides and therapeutic use thereof 有权取代的N-苯基 - 吡咯烷基甲基吡咯烷酰胺及其治疗用途公开(公告)号：US08227504B2
公开(公告)日：2012-07-24
申请号：US12724044
申请日：2010-03-15
申请人： Werngard Czechtizky , Zhongli Gao , William Joseph Hurst , Lothar Schwink , Siegfried Stengelin
发明人： Werngard Czechtizky , Zhongli Gao , William Joseph Hurst , Lothar Schwink , Siegfried Stengelin
IPC分类号： A61K31/5513 , A61K31/4725 , A61K31/4439 , A61K31/422 , A61K31/4184 , A61K31/4178 , A61K31/4155 , A61K31/404 , A61K31/4025 , C07D471/04 , C07D405/14 , C07D407/14 , C07D401/14 , C07D403/14 , C07D403/06
CPC分类号： C07D401/12 , C07D207/09 , C07D401/14 , C07D403/12 , C07D405/12 , C07D413/12 , C07D471/04
摘要： The present invention discloses and claims a series of substituted N-phenyl-pyrrolidinylmethylpyrrolidine amides of formula (I). Wherein R, R1, R2, R3 and R4 are as described herein. More specifically, the compounds of this invention are modulators of H3 receptors and are, therefore, useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases modulated by H3 receptors including diseases associated with the central nervous system. Additionally, this invention also discloses methods of preparation of substituted pyrrolidinylmethylpyrrolidine amides and intermediates therefor.
摘要翻译： 本发明公开并要求一系列取代的式（I）的N-苯基 - 吡咯烷基甲基吡咯烷酰胺。 其中R，R 1，R 2，R 3和R 4如本文所述。 更具体地，本发明的化合物是H3受体的调节剂，因此可用作药剂，特别是用于治疗和/或预防由H3受体调节的各种疾病，包括与中枢神经系统相关的疾病。 此外，本发明还公开了制备取代的吡咯烷基甲基吡咯烷酰胺及其中间体的方法。
-
6.发明申请(CARBOXYLALKYLENEPHENYL)PHENYLOXAMIDES, METHOD FOR THE PRODUCTION THEREOF AND USE OF SAME AS A MEDICAMENT 有权（羧甲基烯丙基）苯并噻唑类，其生产方法及其作为药物的用途公开(公告)号：US20100261645A1
公开(公告)日：2010-10-14
申请号：US12724519
申请日：2010-03-16
申请人： Elisabeth DEFOSSA , Thomas KLABUNDE , Viktoria DIETRICH , Siegfried STENGELIN , Guido HASCHKE , Andreas HERLING , Johanna KUHLMANN-GOTTKE , Stefan BARTOSCHEK
发明人： Elisabeth DEFOSSA , Thomas KLABUNDE , Viktoria DIETRICH , Siegfried STENGELIN , Guido HASCHKE , Andreas HERLING , Johanna KUHLMANN-GOTTKE , Stefan BARTOSCHEK
IPC分类号： A61K31/196 , C07C235/74 , A61K31/245 , A61K38/28 , A61K31/64 , A61K31/426 , A61K38/27 , A61P3/10 , A61P25/00 , A61P25/28 , A61P25/18
CPC分类号： C07C237/04 , C07C235/80
摘要： The invention relates to (carboxylalkylenephenyl)phenyloxamides and their physiologically tolerated salts, and their use as a medicament.
摘要翻译： 本发明涉及（羧基亚烷基苯基）苯氧基酰胺及其生理上耐受的盐，以及它们作为药物的用途。
-
7.发明申请(CYCLOPROPYLPHENYL)PHENYLOXAMIDES, METHOD FOR THE PRODUCTION THEREOF, AND USE OF SAME AS A MEDICAMENT 有权（环丙基苯基）苯甲酰胺，其生产方法及其作为药物的用途公开(公告)号：US20100261644A1
公开(公告)日：2010-10-14
申请号：US12724517
申请日：2010-03-16
申请人： Elisabeth DEFOSSA , Thomas KLABUNDE , Viktoria DIETRICH , Siegfried STENGELIN , Guido HASCHKE , Andreas HERLING , Johanna KUHLMANN-GOTTKE , Stefan BARTOSCHEK
发明人： Elisabeth DEFOSSA , Thomas KLABUNDE , Viktoria DIETRICH , Siegfried STENGELIN , Guido HASCHKE , Andreas HERLING , Johanna KUHLMANN-GOTTKE , Stefan BARTOSCHEK
IPC分类号： A61K31/196 , C07C235/74 , A61K38/28 , A61K31/64 , A61K31/426 , A61K38/27 , A61P3/10 , A61P25/28 , A61P25/00
CPC分类号： C07C233/56 , C07C233/88
摘要： The invention relates to (cyclopropylphenyl)phenyloxamides and their physiologically tolerated salts, and their use as a medicament.
摘要翻译： 本发明涉及（环丙基苯基）苯氧基酰胺及其生理上耐受的盐，以及它们作为药物的用途。
-
8.发明申请USE OF SUBSTITUTED PYRANONE ACID DERIVATIVES FOR THE TREATMENT OF METABOLIC SYNDROME 有权使用替代吡咯烷酮衍生物治疗代谢综合征公开(公告)号：US20100144862A1
公开(公告)日：2010-06-10
申请号：US12504198
申请日：2009-07-16
申请人： Harm BRUMMERHOP , Siegfried STENGELIN , Hubert HEUER , Susanne KILP , Andreas HERLING , Thomas KLABUNDE , Dieter KADEREIT , Matthias URMANN
发明人： Harm BRUMMERHOP , Siegfried STENGELIN , Hubert HEUER , Susanne KILP , Andreas HERLING , Thomas KLABUNDE , Dieter KADEREIT , Matthias URMANN
IPC分类号： A61K31/351 , C07D309/40 , C07D309/38 , A61P1/04 , A61P3/04 , A61P3/10 , A61P9/10 , A61P3/06 , A61P1/18 , A61P35/00 , A61P25/28 , A61P25/16 , A61P17/10 , A61P17/00 , A61P11/06
CPC分类号： A61K31/351
摘要： The invention relates to the use of substituted pyranone acid derivatives and of their physiologically acceptable salts for producing medicaments for treating the metabolic syndrome.
摘要翻译： 本发明涉及取代的吡喃酮酸衍生物及其生理学上可接受的盐用于制备用于治疗代谢综合征的药物的用途。
-
9.发明授权4,5-diphenyl-pyrimidinyl-oxy or -mercapto substituted carboxylic acids, method for the production and use thereof as medicaments 有权4,5-二苯基 - 嘧啶基 - 氧基或巯基取代的羧酸，其生产和使用方法作为药物公开(公告)号：US07709494B2
公开(公告)日：2010-05-04
申请号：US12267925
申请日：2008-11-10
申请人： Elisabeth Defossa , Jochen Goerlitzer , Thomas Klabunde , Viktoria Dietrich , Siegfried Stengelin , Guido Haschke , Andreas Herling , Stefan Bartoschek
发明人： Elisabeth Defossa , Jochen Goerlitzer , Thomas Klabunde , Viktoria Dietrich , Siegfried Stengelin , Guido Haschke , Andreas Herling , Stefan Bartoschek
IPC分类号： C07D239/34 , A61K31/513
CPC分类号： C07D239/34
摘要： This invention relates to a compound of formula I, wherein R1, R2, m, n, V, W, X and Y are as defined herein, or a physiologically tolerated salt thereof, its pharmaceutical composition and use for lowering blood glucose, treating diabetes, or increasing insulin release.
摘要翻译： 本发明涉及式Ⅰ化合物，其中R1，R2，m，n，V，W，X和Y如本文所定义，或其生理耐受盐，其药物组合物和降血糖用途，治疗糖尿病 ，或增加胰岛素释放。
-
10.发明授权4,5-diphenyl-pyrimidinyl substituted carboxylic acids, method for the production and use thereof as medicaments 有权4,5-二苯基 - 嘧啶基取代的羧酸，其制备方法和用作药物公开(公告)号：US07709490B2
公开(公告)日：2010-05-04
申请号：US12267912
申请日：2008-11-10
申请人： Elisabeth Defossa , Jochen Goerlitzer , Thomas Klabunde , Viktoria Dietrich , Siegfried Stengelin , Guido Haschke , Andreas Herling , Stefan Bartoschek
发明人： Elisabeth Defossa , Jochen Goerlitzer , Thomas Klabunde , Viktoria Dietrich , Siegfried Stengelin , Guido Haschke , Andreas Herling , Stefan Bartoschek
IPC分类号： C07D239/26 , A61K31/505
CPC分类号： C07D239/26
摘要： This invention relates to a compound of formula I, wherein R1, R2, m, n and X are as defined herein, or a physiologically tolerated salt thereof, its pharmaceutical composition and use for lowering blood glucose, treating diabetes, or increasing insulin release.
摘要翻译： 本发明涉及式I化合物，其中R 1，R 2，m，n和X如本文所定义，或其生理学上耐受的盐，其药物组合物和用于降低血糖，治疗糖尿病或增加胰岛素释放的用途。
-
-
-
-
-
-
-
-
-
搜索结果
96 条记录 (耗时 0.039 秒)
