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公开(公告)号：US20120199207A1
公开(公告)日：2012-08-09
申请号：US13261268
申请日：2010-11-05
Applicant: Todd A. McAdams , Harold W. Howe , Jeffrey E. Draper , Lawrence C. Farrar
Inventor： Todd A. McAdams , Harold W. Howe , Jeffrey E. Draper , Lawrence C. Farrar
CPC classification number: C12M23/38 , B01F11/0005 , B01F15/0203 , B01F15/0244 , C12M23/28 , C12M37/00 , Y10T137/0318
Abstract: A self-contained breathing closure for flasks and other containers that require gas exchange. An illustrative embodiment of the closure is comprised of a splashguard, an adaptor for attaching the closure to the container, a bellows element and a gas-permeable barrier element. The splashguard is intended to keep liquid contents under vigorous agitation in the container without wetting the gas-permeable barrier. The adaptor couples the closure to the container in a secure fashion. The bellows element allows for repeated changes in the internal volume of the container-closure system. The gas-permeable barrier allows desired gases to enter and leave the container while excluding small particles and/or microorganisms. The technology may be used with existing glass flask technology, or coupled to a plastic flask that may be configured for either single-use, or multiple-use.
Abstract translation: 用于需要气体交换的烧瓶和其他容器的独立呼吸闭合。 闭合件的说明性实施例包括防溅板，用于将封闭件附接到容器的适配器，波纹管元件和透气性屏障元件。 防溅板旨在将液体内容物剧烈搅拌在容器中，而不会润湿透气性屏障。 转接器将闭合件以安全的方式连接到容器上。 波纹管元件允许容器封闭系统的内部体积的重复变化。 透气屏障允许所需气体进入和离开容器，同时排除小颗粒和/或微生物。 该技术可以与现有的玻璃烧瓶技术一起使用，或者与可以配置为单次使用或多次使用的塑料烧瓶相结合。
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公开(公告)号：US08905624B1
公开(公告)日：2014-12-09
申请号：US12806752
申请日：2010-08-20
Applicant: Harold W. Howe , Peter A. Lucon , Jeffrey D. Thornton , Brian Jay Seaholm
Inventor： Harold W. Howe , Peter A. Lucon , Jeffrey D. Thornton , Brian Jay Seaholm
CPC classification number: B01F11/0291 , B01F11/0266 , B01F15/00201 , B01F15/00253 , B01F2215/0409
Abstract: A system and method for controlling a mixing system at a peak energy efficiency point, maximum response point or reduced sound generation point based on displacement, velocity, acceleration or jerk operating conditions.
Abstract translation: 一种用于基于位移，速度，加速度或冲击操作条件在峰值能量效率点，最大响应点或降低的声音产生点处控制混合系统的系统和方法。
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公开(公告)号：US08696778B2
公开(公告)日：2014-04-15
申请号：US13261268
申请日：2010-11-05
Applicant: Todd A. McAdams , Harold W. Howe , Jeffrey E. Draper , Lawrence C. Farrar
Inventor： Todd A. McAdams , Harold W. Howe , Jeffrey E. Draper , Lawrence C. Farrar
CPC classification number: C12M23/38 , B01F11/0005 , B01F15/0203 , B01F15/0244 , C12M23/28 , C12M37/00 , Y10T137/0318
Abstract: A self-contained breathing closure for flasks and other containers that require gas exchange. An illustrative embodiment of the closure is comprised of a splashguard, an adaptor for attaching the closure to the container, a bellows element and a gas-permeable barrier element. The splashguard is intended to keep liquid contents under vigorous agitation in the container without wetting the gas-permeable barrier. The adaptor couples the closure to the container in a secure fashion. The bellows element allows for repeated changes in the internal volume of the container-closure system. The gas-permeable barrier allows desired gases to enter and leave the container while excluding small particles and/or microorganisms. The technology may be used with existing glass flask technology, or coupled to a plastic flask that may be configured for either single-use, or multiple-use.
Abstract translation: 用于需要气体交换的烧瓶和其他容器的独立呼吸闭合。 闭合件的说明性实施例包括防溅板，用于将封闭件附接到容器的适配器，波纹管元件和透气性屏障元件。 防溅板旨在将液体内容物剧烈搅拌在容器中，而不会润湿透气性屏障。 转接器将闭合件以安全的方式连接到容器上。 波纹管元件允许容器封闭系统的内部体积的重复变化。 透气屏障允许所需气体进入和离开容器，同时排除小颗粒和/或微生物。 该技术可以与现有的玻璃烧瓶技术一起使用，或者与可以配置为单次使用或多次使用的塑料烧瓶相结合。
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Patent Agency Ranking
公开(公告)号：US07866878B2
公开(公告)日：2011-01-11
申请号：US11652159
申请日：2007-01-10
Applicant: Harold W. Howe , Jeremiah J. Warriner , Aaron M. Cook , Scott L. Coguill , Lawrence C. Farrar
Inventor： Harold W. Howe , Jeremiah J. Warriner , Aaron M. Cook , Scott L. Coguill , Lawrence C. Farrar
CPC classification number: B01F11/0031 , B06B1/161
Abstract: A method for mixing fluids and/or solids in a manner that can be varied from maintaining the integrity of fragile molecular and biological materials in the mixing vessel to homogenizing heavy aggregate material by supplying large amounts of energy. Variation in the manner of mixing is accomplished using an electronic controller to generate signals to control the frequency and amplitude of the motor(s), which drive an unbalanced shaft assembly to produce a linear vibratory motion. The motor may be a stepper motor, a linear motor or a DC continuous motor. By placing a sensor on the mixing vessel platform to provide feedback control of the mixing motor, the characteristics of agitation in the fluid or solid can be adjusted to optimize the degree of mixing and produce a high quality mixant.
Abstract translation: 一种用于混合流体和/或固体的方法，其可以从维持混合容器中脆性分子和生物材料的完整性到提供大量能量来均匀重质骨料材料而变化。 使用电子控制器实现混合方式的变化以产生信号以控制电动机的频率和振幅，其驱动不平衡的轴组件以产生线性振动运动。 马达可以是步进马达，线性马达或直流马达。 通过将传感器放置在混合容器平台上以提供混合马达的反馈控制，可以调节流体或固体中的搅拌特性以优化混合程度并产生高质量的混合剂。
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公开(公告)号：US08876367B1
公开(公告)日：2014-11-04
申请号：US12924769
申请日：2010-10-05
Applicant: Harold W. Howe , Todd A. McAdams
Inventor： Harold W. Howe , Todd A. McAdams
CPC classification number: B01F11/0008 , B01F15/00733 , B01F15/0074 , B01L3/08 , B01L9/04
Abstract: An apparatus and method for use in the biopharmaceutical and chemical industries to facilitate the temporary attachment of standard laboratory glassware to vibratory mixers and other types of aggressive shaking equipment. The container holder couples the entire flask or container to the mixing equipment in a secure fashion. The technology may be used with conventional glass flasks, or with plastic flasks that can be configured for either single-use or multiple-use. The invention allows for single handed, low force insertion of the flaskware as well as the incorporation of sensors into the container holder.
Abstract translation: 用于生物制药和化学工业的装置和方法，以便于将标准实验室玻璃器皿临时附接到振动混合器和其他类型的侵蚀性摇动设备。 容器保持器将整个烧瓶或容器以安全的方式连接到混合设备。 该技术可以与传统的玻璃烧瓶一起使用，也可以用于可以配置为单次使用或多次使用的塑料瓶。 本发明允许烧瓶的单手，低力插入以及将传感器并入容器保持器中。
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公开(公告)号：US20100254212A1
公开(公告)日：2010-10-07
申请号：US11652159
申请日：2007-01-10
Applicant: Harold W. Howe , Jeremiah J. Warriner , Aaron M. Cook , Scott L. Coguill , Lawrence C. Farrar
Inventor： Harold W. Howe , Jeremiah J. Warriner , Aaron M. Cook , Scott L. Coguill , Lawrence C. Farrar
IPC: B01F11/00
CPC classification number: B01F11/0031 , B06B1/161
Abstract: A method for mixing fluids and/or solids in a manner that can be varied from maintaining the integrity of fragile molecular and biological materials in the mixing vessel to homogenizing heavy aggregate material by supplying large amounts of energy. Variation in the manner of mixing is accomplished using an electronic controller to generate signals to control the frequency and amplitude of the motor(s), which drive an unbalanced shaft assembly to produce a linear vibratory motion. The motor may be a stepper motor, a linear motor or a DC continuous motor. By placing a sensor on the mixing vessel platform to provide feedback control of the mixing motor, the characteristics of agitation in the fluid or solid can be adjusted to optimize the degree of mixing and produce a high quality mixant.
Abstract translation: 一种用于混合流体和/或固体的方法，其可以从维持混合容器中脆性分子和生物材料的完整性到提供大量能量来均匀重质骨料材料而变化。 使用电子控制器实现混合方式的变化以产生信号以控制电动机的频率和振幅，其驱动不平衡的轴组件以产生线性振动运动。 马达可以是步进马达，线性马达或直流马达。 通过将传感器放置在混合容器平台上以提供混合马达的反馈控制，可以调节流体或固体中的搅拌特性以优化混合程度并产生高质量的混合剂。
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公开(公告)号：US07188993B1
公开(公告)日：2007-03-13
申请号：US10766558
申请日：2004-01-26
Applicant: Harold W Howe , Jeremiah J Warriner , Aaron M Cook , Scott L Coguill , Lawrence C Farrar
Inventor： Harold W Howe , Jeremiah J Warriner , Aaron M Cook , Scott L Coguill , Lawrence C Farrar
IPC: B01F11/00
CPC classification number: B01F11/0031 , B06B1/161
Abstract: An apparatus and method for mixing fluids and/or solids in a manner that can be varied from maintaining the integrity of fragile molecular and biological materials in the mixing vessel to homogenizing heavy aggregate material by supplying large amounts of energy. Variation in the manner of mixing is accomplished using an electronic controller to generate signals to control the frequency and amplitude of the motor(s), which drive an unbalanced shaft assembly to produce a linear vibratory motion. The motor may be a stepper motors a linear motor or a DC continuous motor. By placing a sensor on the mixing vessel platform to provide feedback control of the mixing motor, the characteristics of agitation in the fluid or solid can be adjusted to optimize the degree of mixing and produce a high quality mixant.
Abstract translation: 一种用于混合流体和/或固体的装置和方法，其可以从维持混合容器中的易碎分子和生物材料的完整性改变，从而通过提供大量的能量来均匀化重骨料。 使用电子控制器实现混合方式的变化以产生信号以控制电动机的频率和振幅，其驱动不平衡的轴组件以产生线性振动运动。 马达可以是直线马达或直流马达的步进马达。 通过将传感器放置在混合容器平台上以提供混合马达的反馈控制，可以调节流体或固体中的搅拌特性以优化混合程度并产生高质量的混合剂。
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公开(公告)号：US08696991B1
公开(公告)日：2014-04-15
申请号：US12930340
申请日：2011-01-04
Applicant: Harold W. Howe , Timothy S. Troutman , Michael E. Meichle , Adrian L. Krag
Inventor： Harold W. Howe , Timothy S. Troutman , Michael E. Meichle , Adrian L. Krag
IPC: G01N21/00
CPC classification number: G01N21/553 , G01N33/48707 , Y10T436/25 , Y10T436/2575
Abstract: An apparatus and method for detection of anything to which an antibody can be raised, or to which a chemical receptor can be fashioned, based on surface plasmon resonance. The apparatus and method have the capability to detect proteins, viruses, bacteria, toxins, pathogens, contaminants, chemical compounds, or nucleic acids based on surface plasmon resonance and surface receptor technologies which may include antibodies or chemical receptors. The device is field deployable and utilizes a single use sample holder card which includes the sample to be tested, test channels, waste reservoir and a functionalized test surface.
Abstract translation: 基于表面等离子体共振，可以检测能够产生抗体的任何物质或化学受体可被形成的装置和方法。 该装置和方法具有基于表面等离子体共振和可能包括抗体或化学受体的表面受体技术检测蛋白质，病毒，细菌，毒素，病原体，污染物，化学化合物或核酸的能力。 该设备是现场可部署的，并且使用单个使用的样品保持器卡，其包括要测试的样品，测试通道，废物储存器和功能化测试表面。
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