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    Compound containing carboxylate ester and N2S2 ligand bi-functional groups and manufacturing method thereof
    2.
    发明授权
    Compound containing carboxylate ester and N2S2 ligand bi-functional groups and manufacturing method thereof 有权
    含羧酸酯和N2S2配位体双官能团的化合物及其制备方法

    公开(公告)号：US07935833B2

    公开(公告)日：2011-05-03

    申请号：US12203214

    申请日：2008-09-03

    申请人： Show-Wen Liu ,  Tsyh-Lang Lin ,  Cheng-Fang Hsu ,  Cheng-Hsien Lin ,  Tsai-Yueh Luo ,  Lie-Hang Shen ,  Haw-Jan Chen

    发明人： Show-Wen Liu ,  Tsyh-Lang Lin ,  Cheng-Fang Hsu ,  Cheng-Hsien Lin ,  Tsai-Yueh Luo ,  Lie-Hang Shen ,  Haw-Jan Chen

    IPC分类号： C07D207/46

    CPC分类号： C07D207/46 ,  Y02P20/55

    摘要： A compound containing carboxylate ester and N2S2 ligand bi-functional groups and a manufacturing method thereof are disclosed. The S in the N2S2 ligand of the compound containing carboxylate ester and N2S2 ligand bi-functional groups includes a protective group so as to avoid to be oxidized and easy storage. In a complex reaction, the protective group is automatically released As to the active carboxylate ester, it is for reacting with compounds having amino groups such as amines, amino acids, peptides, or protein etc while the N2S2 ligand is for bonding with technetium or rhenium so as to form neutral complex. The compound containing carboxylate ester and N2S2 ligand bi-functional groups is applied to radiopharmaceuticals such as contrast agents for tissues and target agents.

    摘要翻译： 公开了含有羧酸酯和N 2 S 2配位体双官能团的化合物及其制备方法。 含有羧酸酯和N2S2配位体双官能团的化合物的N2S2配体中的S包括保护基，以避免被氧化并容易储存。 在复杂的反应中，保护基被自动释放对于活性羧酸酯，它是与具有氨基的化合物如胺，氨基酸，肽或蛋白质等反应，而N2S2配体与锝或铼键合 从而形成中性复合物。 含有羧酸酯和N 2 S 2配位体双功能基团的化合物被应用于放射性药物，例如用于组织和靶标的造影剂。

    Combination set of Meta-Iodobenzyl guanidine freezing crystal and making method thereof and method for making a radioactive iodine marker
    4.
    发明申请
    Combination set of Meta-Iodobenzyl guanidine freezing crystal and making method thereof and method for making a radioactive iodine marker 审中-公开
    组合甲基碘苄胍冷冻结晶及其制备方法和制备放射性碘标记物的方法

    公开(公告)号：US20080241063A1

    公开(公告)日：2008-10-02

    申请号：US11727996

    申请日：2007-03-29

    申请人： Tsai-Yueh Luo ,  Te-Sheng Liang ,  Chang-Mau Shing ,  Shiou-Shiow Farn ,  Wuu-Jyh Lin ,  Haw-Jan Chen

    发明人： Tsai-Yueh Luo ,  Te-Sheng Liang ,  Chang-Mau Shing ,  Shiou-Shiow Farn ,  Wuu-Jyh Lin ,  Haw-Jan Chen

    IPC分类号： A61K51/00 ,  C07C279/02

    CPC分类号： A61K51/0406 ,  A61K51/1282 ,  C07C279/06

    摘要： The present invention relates to a combination set of meta-iodobenzyl guanidine (MIBG) freezing crystal and making method thereof and method of radioactive marker for making. The combination set of freezing crystal includes a first container having freezing crystal and a second container having sodium acetate buffer solution. The method for making a combination set of freezing crystal includes the steps of mixing (meta-iodobenzyl guanidine)2·sulfuric acid and ammonium sulfate into first non-pyrogenic injection water; getting a first container having freezing crystal after freezing and drying; and getting a second container having the sodium acetate buffer solution after sterilizing. The method of radioactive marker for making includes the steps of adding radioactive iodine ion into freezing crystal to react and adding sodium acetate buffer solution to get radioactive MIBG solution. The present invention adjusts agent easily and is instant to use so the radioactive iodine marker don't lose activity easily before using it.

    摘要翻译： 本发明涉及一种间碘碘苄基胍（MIBG）冷冻结晶的组合及其制备方法和放射性标记物的制备方法。 冷冻结晶组合包括具有冷冻晶体的第一容器和具有乙酸钠缓冲溶液的第二容器。 制备冷冻结晶组合的方法包括将（间碘碘苄基胍）亚磺酸和硫酸铵混合到第一非致热性注射水中的步骤; 在冷冻和干燥后得到具有冷冻晶体的第一容器; 并在灭菌后得到具有乙酸钠缓冲溶液的第二容器。 放射性标记物的制备方法包括将放射性碘离子加入冷冻结晶反应并加入乙酸钠缓冲溶液，得到放射性MIBG溶液的步骤。 本发明容易调节剂并且即时使用，所以放射性碘标记物在使用前不容易失去活性。