专利检索 ap:"Helene Grassier" 第 1 页

1.

发明申请
4-Amino-5-Oxo-8-Phenyl-5H-Pyrido(2,3-D) Pyrimidine Derivatives as Tyrosine Kinase and Raf Kinase Inhibitors for the Treatment of Tumours 失效
标题翻译： 4-氨基-5-氧代-8-苯基-5H-吡啶并（2,3-D）嘧啶衍生物作为酪氨酸激酶和Raf激酶抑制剂治疗肿瘤

公开(公告)号：US20080146560A1

公开(公告)日：2008-06-19

申请号：US11667173

申请日：2005-10-20

申请人： Guenter Hoelzemann , Karl-August Ackermann , Helene Grassier , Alfred Jonczyk , Wilfried Rautenberg , Gema Tarrason , Elisabet Rosell-Vives , Jaume Adan , Claudia Cases

发明人： Guenter Hoelzemann , Karl-August Ackermann , Helene Grassier , Alfred Jonczyk , Wilfried Rautenberg , Gema Tarrason , Elisabet Rosell-Vives , Jaume Adan , Claudia Cases

IPC分类号： A61K31/5377 , C07D401/14 , A61K31/4985 , A61P27/16 , A61P19/00 , A61P35/04 , C07D413/14

CPC分类号： C07D471/04

摘要： Compounds of the formula (I), in which R6, R7, R8, R9, Het1, X and X′ have the meanings indicated in claim 1, are inhibitors of tyrosine kinases, in particular TIE-2, and Raf kinases and can be employed, inter alia, for the treatment of tumours

摘要翻译： 式（I）的化合物，其中R 6，R 7，R 8，R 9， Het 1，X和X'具有权利要求1所示的含义，是酪氨酸激酶，特别是TIE-2和Raf激酶的抑制剂，并且可用于治疗肿瘤