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公开(公告)号:US08389269B2
公开(公告)日:2013-03-05
申请号:US12444760
申请日:2007-10-31
申请人: Cornelis Maria Jacobus Sagt , Cornelis Theodorus Verrips , Walraven Henry Muller , Noël Nicolaas Maria Elisabeth Van Peij
发明人: Cornelis Maria Jacobus Sagt , Cornelis Theodorus Verrips , Walraven Henry Muller , Noël Nicolaas Maria Elisabeth Van Peij
IPC分类号: C12N1/00
CPC分类号: C12P21/00 , C07K14/38 , C12N9/0004 , C12N9/10 , C12N9/12 , C12N9/16 , C12N9/2405 , C12N9/90 , C12N15/80
摘要: The present invention relates to a method to improve the secretion of a protein of interest by a filamentous fungal cell comprising inducing a phenotype in the cell selected from the group consisting of a lowered ERAD, an elevated UPR that does not induce an elevated ERAD, wherein ERAD preferably is lowered. The invention further relates to the filamentous fungal cell comprising the phenotype described above. The invention also relates to polynucleotides and polypeptides whose expression can be modulated in the filamentous fungal cell to obtain the above-described phenotype.
摘要翻译: 本发明涉及一种改善丝状真菌细胞分泌目的蛋白质的方法,包括诱导细胞中的表型,所述细胞选自降低的ERAD,不诱导升高的ERAD的升高的UPR,其中 ERAD优选降低。 本发明还涉及包含上述表型的丝状真菌细胞。 本发明还涉及其表达可以在丝状真菌细胞中调节以获得上述表型的多核苷酸和多肽。
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公开(公告)号:US20060220354A1
公开(公告)日:2006-10-05
申请号:US11385026
申请日:2006-03-20
IPC分类号: B60R21/215 , B32B37/00
CPC分类号: B60R21/2165 , B29C59/007 , B29L2009/00 , B29L2031/3008
摘要: A motor vehicle trim element having weakened areas for an airbag deployment opening is provided. The layered construction of the trim element includes a carrier layer, a spacer layer laminated thereto and a decorative layer. A weakened area of the decorative layer is not visible from the outside. An additional layer of material, made of, for example, a plastic film, is located between the spacer layer and the decorative layer to reduce the likelihood of the weakened area becoming visible from the outside, even under thermal and/or mechanical stress. The additional layer of material may also include a weakened area.
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公开(公告)号:US20050274160A1
公开(公告)日:2005-12-15
申请号:US11138482
申请日:2005-05-27
申请人: Henry Muller , Rudolf Aichner , Hubert Pirkl
发明人: Henry Muller , Rudolf Aichner , Hubert Pirkl
IPC分类号: B60R21/2165 , C14B1/00
CPC分类号: B60R21/2165
摘要: The invention relates to a method for the manufacture of a casing covered at least partially with a leather covering, in particular for use in a vehicle, with a locally defined weakened area of the leather covering characterised in that, prior to the introduction of the leather covering's weakened area, at least the area into which the weakening is to be introduced is subjected to a drying treatment.
摘要翻译: 本发明涉及一种用于制造壳体的方法,所述壳体至少部分地被皮革覆盖物覆盖,特别是用于车辆中的皮革覆盖物的局部限定的弱化区域,其特征在于,在引入皮革之前 覆盖层的弱化区域,至少要引入弱化区域进行干燥处理。
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公开(公告)号:US1654698A
公开(公告)日:1928-01-03
申请号:US13690626
申请日:1926-09-22
申请人: HENRY MULLER
发明人: HENRY MULLER
IPC分类号: E06B3/50
CPC分类号: E06B3/5063 , E06B3/50
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公开(公告)号:US1417097A
公开(公告)日:1922-05-23
申请号:US43974821
申请日:1921-01-25
申请人: HENRY MULLER
发明人: HENRY MULLER
IPC分类号: E06B9/52
CPC分类号: E06B9/52 , Y10T16/5362
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公开(公告)号:US20070018435A1
公开(公告)日:2007-01-25
申请号:US11484365
申请日:2006-07-11
申请人: Henry Muller , Rudolf Aichner
发明人: Henry Muller , Rudolf Aichner
IPC分类号: B60R21/215 , B60R21/205
CPC分类号: B60R21/2165
摘要: An airbag cover, in particular for use in motor vehicles, is disclosed. In one embodiment, the airbag cover includes a molding and a visible cover of leather or leather-like material covering the molding, where at least one layer of a material that is softer than the material of the molding is disposed between the molding and the visible cover. The visible cover has a partial weakening and the transition from the weakened area to the non-weakened area is designed constant. A method for covering a molding disposed above an airbag with a partially weakened visible cover is also disclosed. In one embodiment, the method includes introducing a weakened area into leather or leather-like material forming the visible cover on the side of the visible cover facing away from the visible side. The transition from the weakened area to the non-weakened is designed constant. At least one layer of a material that is softer than the material of the molding is applied on the molding. The visible cover is applied onto the layer of softer material.
摘要翻译: 公开了一种特别用于机动车辆的安全气囊盖。 在一个实施例中,安全气囊盖包括覆盖模制件的皮革或皮革样材料的模制件和可见覆盖物,其中至少一层比模制材料更软的材料层设置在模制件和可见 盖。 可见的覆盖层具有局部弱化,从弱化区域向非弱化区域的转变是恒定的。 还公开了一种用于覆盖设置在具有部分削弱的可见覆盖物的气囊上方的模制件的方法。 在一个实施例中,该方法包括将弱化区域引入形成可见覆盖物的可见覆盖物背面的皮革或皮革样材料,其背面远离可见侧。 从弱化区域向非弱化区域的过渡是恒定的。 至少一层比模制材料更柔软的材料施加在模制件上。 将可见的覆盖层应用到较软材料层上。
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公开(公告)号:US1854756A
公开(公告)日:1932-04-19
申请号:US35802129
申请日:1929-04-25
申请人: HENRY MULLER
发明人: HENRY MULLER
IPC分类号: A47B51/00
CPC分类号: A47B51/00
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公开(公告)号:US1394757A
公开(公告)日:1921-10-25
申请号:US45310621
申请日:1921-03-17
申请人: HENRY MULLER
发明人: HENRY MULLER
IPC分类号: B24D15/02
CPC分类号: B24D15/023
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公开(公告)号:US1346235A
公开(公告)日:1920-07-13
申请号:US31181719
申请日:1919-07-18
申请人: HENRY MULLER
发明人: HENRY MULLER
IPC分类号: B23G1/48
CPC分类号: B23G1/48 , B23G2210/04 , Y10T408/5653
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公开(公告)号:US20130189733A1
公开(公告)日:2013-07-25
申请号:US13750378
申请日:2013-01-25
申请人: CORNELIS MARIA JACOBUS SAGT , CORNELIS THEODORUS VERRIPS , WALRAVEN HENRY MULLER , NOEL NICOLAAS MARIA ELISABETH VAN PEIJ
发明人: CORNELIS MARIA JACOBUS SAGT , CORNELIS THEODORUS VERRIPS , WALRAVEN HENRY MULLER , NOEL NICOLAAS MARIA ELISABETH VAN PEIJ
IPC分类号: C12P21/00 , C12N9/12 , C12N9/10 , C12N15/80 , C12N9/00 , C12N9/90 , C12N9/16 , C07K14/38 , C12N9/24
CPC分类号: C12P21/00 , C07K14/38 , C12N9/0004 , C12N9/10 , C12N9/12 , C12N9/16 , C12N9/2405 , C12N9/90 , C12N15/80
摘要: The present invention relates to a method to improve the secretion of a protein of interest by a filamentous fungal cell comprising inducing a phenotype in the cell selected from the group consisting of a lowered ERAD, an elevated UPR that does not induce an elevated ERAD, wherein ERAD preferably is lowered. The invention further relates to the filamentous fungal cell comprising the phenotype described above. The invention also relates to polynucleotides and polypeptides whose expression can be modulated in the filamentous fungal cell to obtain the above-described phenotype.
摘要翻译: 本发明涉及一种改善丝状真菌细胞分泌目的蛋白质的方法,包括诱导细胞中的表型,所述细胞选自降低的ERAD,不诱导升高的ERAD的升高的UPR,其中 ERAD优选降低。 本发明还涉及包含上述表型的丝状真菌细胞。 本发明还涉及其表达可以在丝状真菌细胞中调节以获得上述表型的多核苷酸和多肽。
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