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1.发明授权Use of perifosine in combination with antimetabolites for the treatment of benign and malignant oncoses in humans and mammals 有权使用去糖苷与抗代谢药联合用于治疗人类和哺乳动物的良性和恶性肿瘤公开(公告)号：US08551977B2
公开(公告)日：2013-10-08
申请号：US12751454
申请日：2010-03-31
IPC分类号： A61K31/70 , A61K31/685
CPC分类号： A61K45/06 , A61K31/685 , A61K2300/00
摘要： The invention relates to the use of alkylphosphocholines in combination with antimetabolite antitumor substances for the treatment of benign and malignant oncoses in humans and animals. It is possible in this connection for the alkylphosphocholines to be employed in a combination according to the invention with one or more antimetabolite antitumor substances. Preferred alkylphosphocholines are described by the Formula II. One such preferred alkylphosphocholine is perifosine.
摘要翻译： 本发明涉及将烷基磷酰胆碱与抗代谢物抗肿瘤物质组合用于治疗人和动物中良性和恶性肿瘤的用途。 在这方面，可以将本发明的组合中的烷基磷酰胆碱与一种或多种抗代谢物抗肿瘤物质一起使用。 优选的烷基磷酰胆碱由式II描述。 一种这样优选的烷基磷酸胆碱是丝胶黄素。
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2.发明申请Use of Alkylphophocholine in Combination with Antitumor Medication for the Treatment of Benign and Malignant Oncoses in Humans and Mammals 有权使用烷基磷酰胆碱与抗肿瘤药物联合治疗人类和哺乳动物中良性和恶性肿瘤公开(公告)号：US20100189784A1
公开(公告)日：2010-07-29
申请号：US12751608
申请日：2010-03-31
IPC分类号： A61K9/28 , A61K31/685 , A61K31/7068 , A61K9/12 , A61P35/00
CPC分类号： A61K45/06 , A61K31/685 , A61K2300/00
摘要： The invention relates to pharmaceutical compositions comprising alkylphosphocholines and antimetabolite antitumor substances. The pharmaceutical compositions of the invention are useful for the treatment of benign and malignant oncoses in humans and animals. Preferred alkylphosphocholines are described by the Formula II. One such preferred alkylphosphocholine is perifosine.
摘要翻译： 本发明涉及包含烷基磷酸胆碱和抗代谢物抗肿瘤物质的药物组合物。 本发明的药物组合物可用于治疗人和动物中的良性和恶性肿瘤。 优选的烷基磷酰胆碱由式II描述。 一种这样优选的烷基磷酸胆碱是丝胶黄素。
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3.发明授权Use of perifosine in combination with antimetabolites for the treatment of benign and malignant oncoses in humans and mammals 有权使用去糖苷与抗代谢药联合用于治疗人类和哺乳动物的良性和恶性肿瘤公开(公告)号：US08507710B2
公开(公告)日：2013-08-13
申请号：US12751608
申请日：2010-03-31
CPC分类号： A61K45/06 , A61K31/685 , A61K2300/00
摘要： The invention relates to pharmaceutical compositions comprising alkylphosphocholines and antimetabolite antitumor substances. The pharmaceutical compositions of the invention are useful for the treatment of benign and malignant oncoses in humans and animals. Preferred alkylphosphocholines are described by the Formula II. One such preferred alkylphosphocholine is perifosine.
摘要翻译： 本发明涉及包含烷基磷酸胆碱和抗代谢物抗肿瘤物质的药物组合物。 本发明的药物组合物可用于治疗人和动物中的良性和恶性肿瘤。 优选的烷基磷酰胆碱由式II描述。 一种这样优选的烷基磷酸胆碱是丝胶黄素。
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4.发明授权Use of alkylphosphocholines in combination with antitumor medications for the treatment of benign and malignant oncoses in humans and mammals 有权使用烷基磷酰胆碱与抗肿瘤药物联合用于治疗人类和哺乳动物的良性和恶性肿瘤公开(公告)号：US08389497B2
公开(公告)日：2013-03-05
申请号：US10632187
申请日：2003-07-30
IPC分类号： A61K31/70 , A61K31/685
CPC分类号： A61K45/06 , A61K31/685 , A61K2300/00
摘要： The invention relates to the use of alkylphosphocholines in combination with antitumor medicaments for the treatment of benign and malignant oncoses in humans and animals. It is possible in this connection for the alkylphosphocholines to be employed in a combination according to the invention with one or a combination of various approved cytostatics. Preferred alkylphosphocholines are described by the Formula II.
摘要翻译： 本发明涉及与抗肿瘤药物组合用于治疗人和动物中良性和恶性肿瘤的烷基磷酰胆碱的用途。 在这方面，可以将本发明的组合中使用的一种或多种批准的细胞抑制剂的组合使用的烷基磷酰胆碱。 优选的烷基磷酰胆碱由式II描述。
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5.发明授权Use of alkylphosphocholines in combination with antimetabolites for the treatment of benign and malignant oncoses in humans and mammals 有权与抗代谢药物组合使用的烷基磷酰胆碱治疗人类和哺乳动物的良性和恶性肿瘤公开(公告)号：US08383605B2
公开(公告)日：2013-02-26
申请号：US12798267
申请日：2010-03-31
IPC分类号： A61K31/70 , A61K31/685 , C07C9/02
CPC分类号： A61K31/706 , A61K31/685 , A61K31/7068 , A61K31/7076 , A61K45/06 , A61K2300/00
摘要： The invention relates to the use of alkylphosphocholines in combination with antimetabolites for the treatment of multiple myeloma, colon cancer or renal cancer. Preferred alkylphosphocholines are described by the Formula II. A particularly effective treatment includes administering a combination of perifosine and capecitabine.
摘要翻译： 本发明涉及与抗代谢物组合用于治疗多发性骨髓瘤，结肠癌或肾癌的烷基磷酰胆碱的用途。 优选的烷基磷酰胆碱由式II描述。 一种特别有效的治疗方法包括给予前列环素和卡培他滨的组合。
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6.发明申请Use of Aalkylphophocholines in Combination with Antitumor Medication for the Treatment of Benign and Melignant Oncoses in Humans and Mammals 有权联合抗肿瘤药物使用烷基磷酰胆碱治疗人类和哺乳动物中良性和恶性肿瘤公开(公告)号：US20100190738A1
公开(公告)日：2010-07-29
申请号：US12751454
申请日：2010-03-31
IPC分类号： A61K31/7068 , A61K31/685 , A61P35/00
CPC分类号： A61K45/06 , A61K31/685 , A61K2300/00
摘要： The invention relates to the use of alkylphosphocholines in combination with antimetabolite antitumor substances for the treatment of benign and malignant oncoses in humans and animals. It is possible in this connection for the alkylphosphocholines to be employed in a combination according to the invention with one or more antimetabolite antitumor substances. Preferred alkylphosphocholines are described by the Formula II. One such preferred alkylphosphocholine is perifosine.
摘要翻译： 本发明涉及将烷基磷酰胆碱与抗代谢物抗肿瘤物质组合用于治疗人和动物中良性和恶性肿瘤的用途。 在这方面，可以将本发明的组合中的烷基磷酰胆碱与一种或多种抗代谢物抗肿瘤物质一起使用。 优选的烷基磷酰胆碱由式II描述。 一种这样优选的烷基磷酸胆碱是丝胶黄素。
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7.发明申请Use of alkylphosphocholines in combination with antimetabolites for the treatment of benign and malignant oncoses in humans and mammals 有权与抗代谢药物组合使用的烷基磷酰胆碱治疗人类和哺乳动物的良性和恶性肿瘤公开(公告)号：US20110028421A1
公开(公告)日：2011-02-03
申请号：US12798267
申请日：2010-03-31
IPC分类号： A61K31/7076 , A61P35/00 , A61K31/7068 , C07F9/10 , A61K31/685 , C07F9/553 , A61K31/706
CPC分类号： A61K31/706 , A61K31/685 , A61K31/7068 , A61K31/7076 , A61K45/06 , A61K2300/00
摘要： The invention relates to the use of alkylphosphocholines in combination with antimetabolites for the treatment of multiple myeloma, colon cancer or renal cancer. Preferred alkylphosphocholines are described by the Formula II. A particularly effective treatment includes administering a combination of perifosine and capecitabine.
摘要翻译： 本发明涉及与抗代谢物组合用于治疗多发性骨髓瘤，结肠癌或肾癌的烷基磷酰胆碱的用途。 优选的烷基磷酰胆碱由式II描述。 一种特别有效的治疗方法包括给予前列环素和卡培他滨的组合。
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