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公开(公告)号：US08936813B2
公开(公告)日：2015-01-20
申请号：US13278919
申请日：2011-10-21
CPC分类号： A61K9/0075 , A61K9/1617 , A61K9/1623 , A61K31/58 , B01D1/18 , B01D1/20 , B01J2/04
摘要： A method and apparatus are provided for atomizing a liquid under dispersal conditions suitable for spray drying at a commercial plant scale. In one embodiment, a liquid atomizer has a structural body adapted for connection with a spray dryer and a plurality of atomizing nozzles. Each of the atomizing nozzles includes a liquid nozzle adapted to disperse a supply of liquid and a gas nozzle adapted to disperse a supply of gas. In another embodiment, a process for producing a powder blend of at least two target substances in a single processing step is provided.
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公开(公告)号：US08524279B2
公开(公告)日：2013-09-03
申请号：US10284960
申请日：2002-10-31
IPC分类号： A61K9/14
CPC分类号： A61K9/0075 , A61K9/1617 , A61K9/1623 , A61K31/58 , B01D1/18 , B01D1/20 , B01J2/04
摘要： A method and apparatus are provided for atomizing a liquid under dispersal conditions suitable for spray drying at a commercial plant scale. In one embodiment, a liquid atomizer has a structural body adapted for connection with a spray dryer and a plurality of atomizing nozzles. Each of the atomizing nozzles includes a liquid nozzle adapted to disperse a supply of liquid and a gas nozzle adapted to disperse a supply of gas. In another embodiment, a process for producing a powder blend of at least two target substances in a single processing step is provided.
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公开(公告)号：US20110297755A1
公开(公告)日：2011-12-08
申请号：US13155546
申请日：2011-06-08
IPC分类号： B05B1/00
CPC分类号： B05B7/0441 , A61K9/0073 , A61K9/1682 , B05B7/0416 , B05B7/0433 , B05B7/0466 , B05B7/062 , B05B7/065 , B05B7/067 , B05B7/0807 , F23D2900/11101
摘要： A method of forming droplets comprises flowing a liquid through a channel; spreading the liquid into a thin film in the channel; and impinging the thin film with a flowing gas to atomize the liquid into droplets. The droplets may then be dried to produce dried particles, such as particles comprising a pharmaceutical active agent. The droplets formed by the disclosed process have improved size and/or size distribution characteristics.
摘要翻译： 形成液滴的方法包括使液体流过通道; 将液体分散在通道中的薄膜中; 并用流动的气体冲击薄膜以将液体雾化成液滴。 然后可以将液滴干燥以产生干燥的颗粒，例如包含药物活性剂的颗粒。 由所公开的方法形成的液滴具有改进的尺寸和/或尺寸分布特性。
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公开(公告)号：US07967221B2
公开(公告)日：2011-06-28
申请号：US10738912
申请日：2003-12-16
IPC分类号： F23D11/10
CPC分类号： B05B7/0441 , A61K9/0073 , A61K9/1682 , B05B7/0416 , B05B7/0433 , B05B7/0466 , B05B7/062 , B05B7/065 , B05B7/067 , B05B7/0807 , F23D2900/11101
摘要： A method of forming droplets comprises flowing a liquid through a channel; spreading the liquid into a thin film in the channel; and impinging the thin film with a flowing gas to atomize the liquid into droplets. The droplets may then be dried to produce dried particles, such as particles comprising a pharmaceutical active agent. The droplets formed by the disclosed process have improved size and/or size distribution characteristics.
摘要翻译： 形成液滴的方法包括使液体流过通道; 将液体分散在通道中的薄膜中; 并用流动的气体冲击薄膜以将液体雾化成液滴。 然后可以将液滴干燥以产生干燥的颗粒，例如包含药物活性剂的颗粒。 由所公开的方法形成的液滴具有改进的尺寸和/或尺寸分布特性。
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公开(公告)号：US08616464B2
公开(公告)日：2013-12-31
申请号：US13155546
申请日：2011-06-08
IPC分类号： B05B7/06
CPC分类号： B05B7/0441 , A61K9/0073 , A61K9/1682 , B05B7/0416 , B05B7/0433 , B05B7/0466 , B05B7/062 , B05B7/065 , B05B7/067 , B05B7/0807 , F23D2900/11101
摘要： A method of forming droplets comprises flowing a liquid through a channel; spreading the liquid into a thin film in the channel; and impinging the thin film with a flowing gas to atomize the liquid into droplets. The droplets may then be dried to produce dried particles, such as particles comprising a pharmaceutical active agent. The droplets formed by the disclosed process have improved size and/or size distribution characteristics.
摘要翻译： 形成液滴的方法包括使液体流过通道; 将液体分散在通道中的薄膜中; 并用流动的气体冲击薄膜以将液体雾化成液滴。 然后可以将液滴干燥以产生干燥的颗粒，例如包含药物活性剂的颗粒。 由所公开的方法形成的液滴具有改进的尺寸和/或尺寸分布特性。
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公开(公告)号：US20120038073A1
公开(公告)日：2012-02-16
申请号：US13278919
申请日：2011-10-21
IPC分类号： B29B9/00
CPC分类号： A61K9/0075 , A61K9/1617 , A61K9/1623 , A61K31/58 , B01D1/18 , B01D1/20 , B01J2/04
摘要： A method and apparatus are provided for atomizing a liquid under dispersal conditions suitable for spray drying at a commercial plant scale. In one embodiment, a liquid atomizer has a structural body adapted for connection with a spray dryer and a plurality of atomizing nozzles. Each of the atomizing nozzles includes a liquid nozzle adapted to disperse a supply of liquid and a gas nozzle adapted to disperse a supply of gas. In another embodiment, a process for producing a powder blend of at least two target substances in a single processing step is provided.
摘要翻译： 提供了一种方法和装置，用于在适用于商业植物规模的喷雾干燥的分散条件下使液体雾化。 在一个实施例中，液体雾化器具有适于与喷雾干燥器和多个雾化喷嘴连接的结构体。 每个雾化喷嘴包括适于分散液体供应的液体喷嘴和适于分散气体供应的气体喷嘴。 在另一个实施方案中，提供了在单个加工步骤中生产至少两种目标物质的粉末共混物的方法。
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