公开(公告)号：US20060160089A1

公开(公告)日：2006-07-20

申请号：US10551408

申请日：2004-03-30

申请人： Yoshihiro Ito ,  Hirokazu Hasuda ,  Tomohiro Konno ,  Kazuhiko Ishihara ,  Tetsuya Yamauchi

发明人： Yoshihiro Ito ,  Hirokazu Hasuda ,  Tomohiro Konno ,  Kazuhiko Ishihara ,  Tetsuya Yamauchi

IPC分类号： C12Q1/68 ,  G01N33/53 ,  C08G63/48 ,  C12M1/34

CPC分类号： G01N33/54393

摘要： An agent for fixing (a) substance(s), which can fix various substances to be fixed on a substrate via covalent bonds and which has an excellent effect for the prevention of non-specific adsorption is disclosed. A polymer containing a plurality of phosphorylcholine groups and photoreactive groups in one molecule is used. The polymer binds to the substrate and to the substance to be fixed via the photoreactive groups, thereby the substance to be fixed is bound to the substrate via covalent bonds through the polymer, and non-specific adsorption is effectively prevented by the phosphorylcholine groups. Further, an agent for fixing (a) substance(s) for fixing the substance on a substrate, comprising a nonionic water-soluble macromolecule having at least 2 photoreactive groups in one molecule was also provided.

摘要翻译： 公开了一种用于固定（a）物质的试剂，其可以通过共价键固定各种待固定在基材上的物质，并且其具有优异的防止非特异性吸附的效果。 使用在一个分子中含有多个磷酸胆碱基团和光反应基团的聚合物。 聚合物通过光反应基团与基体和待固定的物质结合，通过共聚键将被固定的物质与基底结合，通过磷酸胆碱基团有效地防止非特异性吸附。 此外，还提供了用于将（a）用于将物质固定在基材上的物质（包括在一个分子中具有至少2个光反应性基团的非离子水溶性大分子）的试剂。