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1.发明授权公开(公告)号：US09138511B2
公开(公告)日：2015-09-22
申请号：US14319184
申请日：2014-06-30
发明人： Hyung-Il Kim , Kazuhiko Ishihara
CPC分类号： A61L31/041 , A61F2/82 , A61F2210/0004 , A61L27/14 , A61L27/26 , A61L27/507 , A61L31/148 , A61L2300/80 , C08L101/02 , C08L67/04
摘要： A bioabsorbable blend comprising poly(L-lactide) (PLLA) and a phosphorylcholine group-containing copolymer (PPCP) capable of enduring the mechanical strength of blood vessel walls and applicable for fabricating cardiovascular devices was developed. The blend acts as a scaffold to support blood vessel walls during vascular healing and undergoes biodegradation in vivo after vascular healing is complete. Furthermore, the blend can prevent the formation and adsorption of thrombi.
摘要翻译： 开发了能够耐受血管壁的机械强度并适用于制造心血管装置的包含聚（L-丙交酯）（PLLA）和含磷酸胆碱基团的共聚物（PPCP）的生物可吸收混合物。 混合物作为支架，用于在血管愈合期间支持血管壁，并且在血管愈合完成后在体内经历生物降解。 此外，共混物可以防止血栓的形成和吸附。
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公开(公告)号：US20140371395A1
公开(公告)日：2014-12-18
申请号：US14319184
申请日：2014-06-30
发明人： Hyung-Il Kim , Kazuhiko Ishihara
CPC分类号： A61L31/041 , A61F2/82 , A61F2210/0004 , A61L27/14 , A61L27/26 , A61L27/507 , A61L31/148 , A61L2300/80 , C08L101/02 , C08L67/04
摘要： A bioabsorbable blend comprising poly(L-lactide) (PLLA) and a phosphorylcholine group-containing copolymer (PPCP) capable of enduring the mechanical strength of blood vessel walls and applicable for fabricating cardiovascular devices was developed. The blend acts as a scaffold to support blood vessel walls during vascular healing and undergoes biodegradation in vivo after vascular healing is complete. Furthermore, the blend can prevent the formation and adsorption of thrombi.
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公开(公告)号：US08795841B2
公开(公告)日：2014-08-05
申请号：US13130125
申请日：2009-11-20
CPC分类号： C08F291/18 , C08F283/06 , Y10T428/31855 , C08F230/02 , C08F2/48
摘要： Disclosed is a graft polymerization method which has solved problems involved in use of a solvent, a radical initiator and high-energy radiation when a monomer is graft-polymerized on the surface of a polymer base. The graft polymerization method is characterized in that a polymerization product is obtained by immersing a polymer base (i) having a ketone group on the surface into a reaction system containing a monomer (ii) and then irradiating the polymer base (i) with light so that polymerization of the monomer starts from the surface of the polymer base (i).
摘要翻译： 公开了一种接枝聚合方法，其解决了当单体在聚合物基材的表面上接枝聚合时涉及使用溶剂，自由基引发剂和高能辐射的问题。 接枝聚合方法的特征在于，通过将表面上具有酮基的聚合物基（ⅰ）浸渍到含有单体（ⅱ）的反应体系中，然后用光照射聚合物基体（i），得到聚合产物 单体的聚合从聚合物基质（i）的表面开始。
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公开(公告)号：US08551332B2
公开(公告)日：2013-10-08
申请号：US12495936
申请日：2009-07-01
IPC分类号： B01D15/08
CPC分类号： B01J20/286 , B01D15/3804 , B01J20/28004 , B01J20/3204 , B01J20/3219 , B01J20/3242 , B01J20/3248 , B01J20/3259 , B01J20/3274 , B01J20/3285 , B01J2220/58 , C07F9/091 , G01N33/54393
摘要： The present invention is affinity particles that are characterized by having phosphorylcholine groups represented by the following formula (1) covalently bonded onto the surface of inorganic powder and also by having ligands having specific affinity with a certain target substance covalently bonded or adsorbed onto the surface of inorganic powder.The object of the present invention is to provide an affinity separation method that uses affinity particles utilizing inexpensive inorganic particles and is capable of separating the target substance easily and with high accuracy.
摘要翻译： 本发明是亲水性粒子，其特征在于将由下式（1）表示的磷酸胆碱基团共价键合到无机粉末的表面上，还可以通过将具有特定亲和力的配体与共价键合或吸附在 无机粉末。 本发明的目的是提供使用廉价的无机粒子的亲和粒子的亲和力分离方法，能够容易且高精度地分离目标物质。
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公开(公告)号：US08318865B2
公开(公告)日：2012-11-27
申请号：US10593682
申请日：2005-05-18
IPC分类号： C08C19/24
CPC分类号： C08J7/12 , A61F2/16 , A61F2002/1699 , A61L27/28 , G02B1/043
摘要： The present invention is a method of manufacturing an eye lens material having a process in which a phosphorylcholine group-containing chemical compound represented by the following formula (1) is reacted and covalently bonded to the surface of an eye lens material having hydroxyl groups wherein the chemical compound represented by the following formula (2) is reacted and covalently bonded through ester-bonding to the eye lens material in an organic solvent.The object of the present invention is to provide an eye lens material that prevents protein adsorption and a method of manufacturing thereof.
摘要翻译： 本发明是一种眼镜透镜材料的制造方法，其具有下述通式（1）所示的含磷酰胆碱基的化合物与具有羟基的眼晶状体材料的表面反应并共价键合的方法，其中， 由下式（2）表示的化合物通过酯键在有机溶剂中与眼晶体材料反应并共价键合。 本发明的目的是提供一种防止蛋白质吸附的眼用透镜材料及其制造方法。
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6.发明授权公开(公告)号：US08277834B2
公开(公告)日：2012-10-02
申请号：US10592772
申请日：2005-05-18
IPC分类号： A61K31/80
摘要： The present invention is a method of manufacturing an eye lens material having a process in which a phosphorylcholine group-containing chemical compound represented by the following formula (1) is reacted and covalently bonded onto the surface of an eye lens material wherein a chemical compound having an end amino group is introduced to said eye lens material and then the chemical compound represented by the following formula (2) or (3) is introduced through said chemical compound having an end amino group.The object of the present invention is to provide a method of manufacturing a contact lens that prevents protein adsorption.
摘要翻译： 本发明是一种眼透镜材料的制造方法，其具有以下处理：将由下式（1）表示的含磷酰胆碱基的化合物反应并共价键合到眼晶状体材料的表面上，其中具有 将末端氨基引入所述眼晶状体材料中，然后通过具有末端氨基的化合物引入由下式（2）或（3）表示的化合物。 本发明的目的是提供一种制造防止蛋白质吸附的隐形眼镜的方法。
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公开(公告)号：US08236873B2
公开(公告)日：2012-08-07
申请号：US10593544
申请日：2005-05-18
IPC分类号： G02B1/04
摘要： An eye lens material preventing protein adsorption is manufactured by reacting in a reaction medium of either water, an organic solvent, or a water/organic solvent mixture an eye lens material having OH groups with a phosphorylcholine group-containing compound of formula (1), thereby forming an acetal bond according to formula (2) which covalently bonds the phosphorylcholine group-containing compound to a surface of the eye lens material.
摘要翻译： 通过在水，有机溶剂或水/有机溶剂混合物，具有OH基的眼晶状体材料与含磷酰胆碱基团的式（1）化合物的反应介质中反应来制造防止蛋白质吸附的眼镜片材料， 从而形成根据式（2）的缩醛键，其将含磷酰胆碱基团的化合物共价键合到眼晶状体材料的表面。
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公开(公告)号：US20120197407A1
公开(公告)日：2012-08-02
申请号：US13390971
申请日：2010-08-18
CPC分类号： A61L27/14 , A61F2/30767 , A61F2/32 , A61F2002/30673 , A61L27/18 , A61L27/34 , A61L27/50 , A61L2400/10 , A61L2430/24 , C08L101/02 , C08L71/00 , C08L33/10
摘要： Disclosed are: a sliding member which is capable of maintaining wear resistance over a long period of time; an artificial joint member in which the polymer base is reduced in thickness; and an artificial joint which exhibits high lubricating properties in the body, biocompatibility and resistance to dislocation. Specifically disclosed is a polymer sliding material which has a coating layer (B) that is composed of a graft polymer containing a phosphorylcholine group and having a density of at least 1.4 g/cm3 on at least a part of the surface of a polymer base (A) that has a ketone group on the surface. The sliding material can be obtained by immersing the polymer base (A) into a liquid of a monomer (C) that has a phosphorylcholine group, and causing surface graft polymerization by irradiation of light. Also specifically disclosed are an artificial joint member using the polymer sliding material, and an artificial joint.
摘要翻译： 公开了一种能够长时间保持耐磨性的滑动构件; 聚合物基材的厚度减小的人造关节部件; 以及在体内具有高润滑性的人造关节，生物相容性和耐位错性。 具体公开了一种聚合物滑动材料，其具有由聚合物基材的至少一部分表面上含有磷酸胆碱基并具有至少1.4g / cm 3的密度的接枝聚合物构成的涂层（B） A）表面上有一个酮基。 滑动材料可以通过将聚合物基体（A）浸渍在具有磷酰胆碱基团的单体（C）的液体中，并通过照射光进行表面接枝聚合来获得。 还具体公开了使用聚合物滑动材料的人造关节构件和人造关节。
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公开(公告)号：US20090321357A1
公开(公告)日：2009-12-31
申请号：US12490216
申请日：2009-06-23
CPC分类号： B01J20/286 , B01D15/3804 , B01J20/28004 , B01J20/3204 , B01J20/3219 , B01J20/3242 , B01J20/3248 , B01J20/3259 , B01J20/3274 , B01J20/3285 , B01J2220/58 , C07F9/091 , G01N33/54393
摘要： The present invention is affinity particles that are characterized by having phosphorylcholine groups represented by the following formula (1) covalently bonded onto the surface of inorganic powder and also by having ligands having specific affinity with a certain target substance covalently bonded or adsorbed onto the surface of inorganic powder.The object of the present invention is to provide an affinity separation method that uses affinity particles utilizing inexpensive inorganic particles and is capable of separating the target substance easily and with high accuracy.
摘要翻译： 本发明是亲水性粒子，其特征在于将由下式（1）表示的磷酸胆碱基团共价键合到无机粉末的表面上，还可以通过将具有特定亲和力的配体与共价键合或吸附在 无机粉末。 本发明的目的是提供使用廉价的无机粒子的亲和粒子的亲和力分离方法，能够容易且高精度地分离目标物质。
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10.发明申请High Wear-Resistant Bearing Material and Artificial Joint Replacement Using the Same 有权高耐磨轴承材料和使用其的人造关节置换公开(公告)号：US20090306781A1
公开(公告)日：2009-12-10
申请号：US12223669
申请日：2007-02-05
申请人： Masayuki Kyomoto , Toru Moro , Kazuhiko Ishihara , Tomohiro Konno , Kozo Nakamura , Yoshio Takatori , Hiroshi Kawaguchi , Hiroaki Takadama , Makoto Kondo , Noboru Yamawaki , Takeshi Nizuka , Masami Hashimoto
发明人： Masayuki Kyomoto , Toru Moro , Kazuhiko Ishihara , Tomohiro Konno , Kozo Nakamura , Yoshio Takatori , Hiroshi Kawaguchi , Hiroaki Takadama , Makoto Kondo , Noboru Yamawaki , Takeshi Nizuka , Masami Hashimoto
CPC分类号： A61F2/30767 , A61F2/32 , A61F2/34 , A61F2/36 , A61F2/3662 , A61F2/367 , A61F2/3676 , A61F2/38 , A61F2/3804 , A61F2/3859 , A61F2/389 , A61F2/40 , A61F2/4059 , A61F2/4081 , A61F2/4202 , A61F2/4241 , A61F2/4425 , A61F2/468 , A61F2002/3065 , A61F2002/30654 , A61F2002/30884 , A61F2002/30904 , A61F2002/30934 , A61F2002/3493 , A61F2002/3611 , A61F2002/3625 , A61F2002/3631 , A61F2002/3682 , A61F2002/4018 , A61F2002/4051 , A61F2002/4062 , A61L27/34 , A61L27/50 , Y10T428/31913
摘要： The present invention provides a bearing material that is excellent in durability and is capable of maintaining wear resistance over a long period of time. The bearing material of the present invention is a high wear-resistance bearing material 10 for being used under a humid environment comprising: a base body 12 made of a polymer material having a methylene group; and a polymer layer 30 covering a bearing surface 16 of the substrate 12, the polymer layer 30 comprising polymer chains which have a phosphorylcholine group and are grafted from the bearing surface 16, wherein a phosphoric index of the sliding surface 16 which is calculated by dividing a peak intensity of phosphate group in an infrared spectrum measured on the sliding surface by a peak intensity of the methylene group therein is not less than 0.28.
摘要翻译： 本发明提供耐久性优异并能够长时间保持耐磨性的轴承材料。 本发明的轴承材料是用于在潮湿环境下使用的高耐磨轴承材料10，包括：由具有亚甲基的聚合物材料制成的基体12; 以及覆盖基板12的支承面16的聚合物层30，聚合物层30包含具有磷酸胆碱基并且从支承表面16接枝的聚合物链，其中滑动表面16的磷酸指数通过除以 在滑动面上测定的红外光谱中的亚甲基的峰强度的磷酸基的峰强度不小于0.28。
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