公开(公告)号：US09610354B2

公开(公告)日：2017-04-04

申请号：US14112317

申请日：2012-04-16

申请人： Takashi Okada ,  Shin'ichi Takeda ,  Hiromi Kinoh

发明人： Takashi Okada ,  Shin'ichi Takeda ,  Hiromi Kinoh

IPC分类号： A61K47/42 ,  A61K9/14 ,  A61K9/51 ,  A61K31/7088 ,  A61K31/713 ,  A61K47/26

CPC分类号： A61K9/5184 ,  A61K9/14 ,  A61K31/7088 ,  A61K31/713 ,  A61K47/26 ,  A61K47/42 ,  A61K48/0008 ,  A61K48/0091 ,  C12N5/00 ,  C12N7/00 ,  C12N15/113 ,  C12N2310/14 ,  C12N2320/32 ,  C12N2510/02 ,  C12N2710/10042 ,  C12N2750/00042 ,  C12N2750/00051 ,  C12N2750/14142

摘要： An object of the present invention is to develop and provide a method for conveniently introducing a nucleic acid, a peptide, and/or a low-molecular-weight compound into an empty capsid with viral early infection activities kept. The present invention provides a method for producing a drug delivery particle, comprising the steps of: mixing an empty capsid or an empty particle with a drug including a nucleic acid, a peptide, and/or a low-molecular-weight compound in a solution comprising 0.1 to 20% of a surfactant; and keeping the obtained mixed solution at −5 to 50° C. to introduce the drug into the empty capsid or the empty particle.

公开(公告)号：US20140044794A1

公开(公告)日：2014-02-13

申请号：US14112317

申请日：2012-04-16

申请人： Takashi Okada ,  Shin'ichi Takeda ,  Hiromi Kinoh

发明人： Takashi Okada ,  Shin'ichi Takeda ,  Hiromi Kinoh

IPC分类号： A61K47/42 ,  A61K9/14

CPC分类号： A61K9/5184 ,  A61K9/14 ,  A61K31/7088 ,  A61K31/713 ,  A61K47/26 ,  A61K47/42 ,  A61K48/0008 ,  A61K48/0091 ,  C12N5/00 ,  C12N7/00 ,  C12N15/113 ,  C12N2310/14 ,  C12N2320/32 ,  C12N2510/02 ,  C12N2710/10042 ,  C12N2750/00042 ,  C12N2750/00051 ,  C12N2750/14142

摘要： An object of the present invention is to develop and provide a method for conveniently introducing a nucleic acid, a peptide, and/or a low-molecular-weight compound into an empty capsid with viral early infection activities kept. The present invention provides a method for producing a drug delivery particle, comprising the steps of: mixing an empty capsid or an empty particle with a drug including a nucleic acid, a peptide, and/or a low-molecular-weight compound in a solution comprising 0.1 to 20% of a surfactant; and keeping the obtained mixed solution at −5 to 50° C. to introduce the drug into the empty capsid or the empty particle.

摘要翻译： 本发明的目的是开发并提供一种便利地将核酸，肽和/或低分子量化合物引入具有保持的病毒性早期感染活性的空衣壳中的方法。 本发明提供一种制备药物递送颗粒的方法，其包括以下步骤：将空衣壳或空粒子与包含核酸，肽和/或低分子量化合物的药物在溶液中混合 包含0.1-20％的表面活性剂; 并将所得混合溶液保持在-5至50℃以将药物引入空的衣壳或空的颗粒中。