公开(公告)号：US5294439A

公开(公告)日：1994-03-15

申请号：US379256

申请日：1989-07-13

申请人： Heinojo Yamasaka ,  Hiroyasu Uchiyama ,  Hirotaka Masuda ,  Yoshiomi Sakamoto ,  Yoshimi Nakamigawa ,  Mitsuko Yoshioka ,  Terumasa Moriga

发明人： Heinojo Yamasaka ,  Hiroyasu Uchiyama ,  Hirotaka Masuda ,  Yoshiomi Sakamoto ,  Yoshimi Nakamigawa ,  Mitsuko Yoshioka ,  Terumasa Moriga

IPC分类号： C07D235/28 ,  A61K31/41 ,  A61K31/415 ,  A61K31/74

CPC分类号： C07D235/28

摘要： A stabilized physiologically active benzimidazole derivative having the formula (I): ##STR1## wherein R.sup.1 is hydrogen atom, an alkyl group having 1 to 8 carbon atoms, a fluoroalkyl group having 1 to 6 carbon atoms, a cycloalkyl group, phenyl group or an aralkyl group, R.sup.2 is hydrogen atom or a lower alkyl group, or R.sup.1 and R.sup.2 together with the adjacent nitrogen atom form a ring, and each of R.sup.3a, R.sup.3b, R.sup.4a, R.sup.4b and R.sup.4c independently is hydrogen atom, a halogen atom, a fluoroalkyl group having 1 to 6 carbon atoms, a lower alkyl group, a lower alkoxy group, a lower alkoxycarbonyl group or an amino group. The stabilized benzimidazole derivative is in amorphous form or present in contact with a basic material.

摘要翻译： 具有式（I）的稳定的生理活性苯并咪唑衍生物：其中R 1是氢原子，具有1至8个碳原子的烷基，具有1至6个碳原子的氟代烷基，环烷基，苯基 基团或芳烷基，R 2是氢原子或低级烷基，或者R 1和R 2与相邻的氮原子一起形成环，R3a，R3b，R4a，R4b和R4c各自独立地是氢原子，卤素原子 ，碳原子数1〜6的氟代烷基，低级烷基，低级烷氧基，低级烷氧基羰基或氨基。 稳定的苯并咪唑衍生物是无定形形式或与碱性材料接触。

公开(公告)号：US08430591B1

公开(公告)日：2013-04-30

申请号：US13402788

申请日：2012-02-22

申请人： Keishi Okamoto ,  Satoru Ando ,  Tatsuyuki Nakatani ,  Yuki Nitta ,  Kunihiro Toyota ,  Kouichi Takayama ,  Takumi Kajiwara ,  Hirotaka Masuda

发明人： Keishi Okamoto ,  Satoru Ando ,  Tatsuyuki Nakatani ,  Yuki Nitta ,  Kunihiro Toyota ,  Kouichi Takayama ,  Takumi Kajiwara ,  Hirotaka Masuda

IPC分类号： B43K7/10

CPC分类号： B43K7/02 ,  B43K1/082 ,  B43K1/084 ,  B43K7/10

摘要： A ballpoint pen tip includes a ball and a ball holder for rotatably holding the ball. The ball includes a ball body and a first carbonaceous film formed so as to cover a surface of the ball body. The first carbonaceous film has carbon atoms and oxygen atoms bonded to some of the carbon atoms. The ratio of carbon atoms bonded to oxygen atoms to the total carbon atoms at a surface of the first carbonaceous film is equal to or greater than 0.1.

摘要翻译： 圆珠笔尖包括球和用于可旋转地保持球的球保持器。 球包括球体和形成为覆盖球体表面的第一碳质膜。 第一碳质膜具有与一些碳原子键合的碳原子和氧原子。 与氧原子键合的碳原子与第一碳质膜表面的总碳原子的比例等于或大于0.1。