公开(公告)号：US20060287527A1

公开(公告)日：2006-12-21

申请号：US11446448

申请日：2006-06-01

申请人： Yasuyuki Miyazawa ,  Takahiro Sagae ,  Yutaka Ishii ,  Hiroyuki Yazaki ,  Makoto Funabora ,  Satoru Yamazaki

发明人： Yasuyuki Miyazawa ,  Takahiro Sagae ,  Yutaka Ishii ,  Hiroyuki Yazaki ,  Makoto Funabora ,  Satoru Yamazaki

IPC分类号： C07D239/34

CPC分类号： C07D239/56 ,  C07C67/31 ,  C07C67/343 ,  C07D239/34 ,  C07D239/52 ,  C07C69/734 ,  C07C69/732

摘要： Processes for producing a compound represented by the formula (1), which includes an acrylic acid derivative and is useful as an agricultural chemical or medicine. One of the processes comprises the step of formulating a compound (3) and converting the OH of the resultant compound (2) into OR″. The first step comprises reacting a formic or orthoformic ester in the presence of a Lewis acid and a base. The second step comprises reacting the compound with R″OH or with R″OH and CH(OR″)3 under acidic conditions or using a phase-transfer catalyst in a two-phase system and regulating the base and the concentration thereof to stereoselectively synthesize the target compound. In another, process, the compound is efficiently produced without isolating the compound. The compound can also be produced without the compound (2).

摘要翻译： 制备由式（1）表示的化合物的方法，其包括丙烯酸衍生物并且可用作农业化学品或药物。 其中一个方法包括配制化合物（3）并将所得化合物（2）的OH转化为OR“的步骤。 第一步包括在路易斯酸和碱的存在下使甲酸或正癸酸酯反应。 第二步包括在酸性条件下或在两相体系中使用相转移催化剂使化合物与R''OH或与R''OH和CH（OR“）3'反应， 调节碱和其浓度以立体选择性合成目标化合物。 在另一个方法中，化合物在不分离化合物的情况下有效生产。 化合物也可以不用化合物（2）制备。

公开(公告)号：US20060058521A1

公开(公告)日：2006-03-16

申请号：US10529392

申请日：2003-10-02

申请人： Mitsuru Takase ,  Takahiro Sagae ,  Hiroyuki Yazaki ,  Shigeo Mori ,  Daisuke Asanuma

发明人： Mitsuru Takase ,  Takahiro Sagae ,  Hiroyuki Yazaki ,  Shigeo Mori ,  Daisuke Asanuma

IPC分类号： C07D205/02

CPC分类号： C07D499/893 ,  C07D499/88

摘要： The present invention provides a method for preparing an organic compound, which comprises a dehydration step of distilling off water from a polar organic solvent solution containing the organic compound and water to bring the concentration of water below a given level, wherein the dehydration step comprises distilling off water together with the polar organic solvent while adding a polar organic solvent to the solution, or comprises repeating several cycles of adding a polar organic solvent to the solution and then distilling off water together with the polar organic solvent. The present invention further provides the preparation of an organic compound, which enables efficient isolation of the target product in high isolated yield from a polar organic solvent solution containing the organic compound, water and, if necessary, a compound which produces, upon coming into contact with water or the like, a substance accelerating the decomposition of the organic compound.

摘要翻译： 本发明提供了一种制备有机化合物的方法，该方法包括从含有有机化合物和水的极性有机溶剂溶液中蒸馏出水以使水的浓度低于给定水平的脱水步骤，其中脱水步骤包括蒸馏 将极性有机溶剂与极性有机溶剂一起加入到溶液中，或者包括重复多次向溶液中加入极性有机溶剂，然后与极性有机溶剂一起蒸馏出水。 本发明还提供有机化合物的制备，其能够以高分离产率从含有有机化合物的极性有机溶剂溶液，水和必要时的化合物在接触时产生高分离产物。 用水等加速有机化合物分解的物质。

公开(公告)号：US07358356B2

公开(公告)日：2008-04-15

申请号：US10529392

申请日：2003-10-02

申请人： Mitsuru Takase ,  Takahiro Sagae ,  Hiroyuki Yazaki ,  Shigeo Mori ,  Daisuke Asanuma

发明人： Mitsuru Takase ,  Takahiro Sagae ,  Hiroyuki Yazaki ,  Shigeo Mori ,  Daisuke Asanuma

IPC分类号： C07D499/18

CPC分类号： C07D499/893 ,  C07D499/88

摘要： The present invention provides a method for preparing an organic compound, which comprises a dehydration step of distilling off water from a polar organic solvent solution containing the organic compound and water to bring the concentration of water below a given level, wherein the dehydration step comprises distilling off water together with the polar organic solvent while adding a polar organic solvent to the solution, or comprises repeating several cycles of adding a polar organic solvent to the solution and then distilling off water together with the polar organic solvent. The present invention further provides the preparation of an organic compound, which enables efficient isolation of the target product in high isolated yield from a polar organic solvent solution containing the organic compound, water and, if necessary, a compound which produces, upon coming into contact with water or the like, a substance accelerating the decomposition of the organic compound.

摘要翻译： 本发明提供了一种制备有机化合物的方法，该方法包括从含有有机化合物和水的极性有机溶剂溶液中蒸馏出水以使水的浓度低于给定水平的脱水步骤，其中脱水步骤包括蒸馏 将极性有机溶剂与极性有机溶剂一起加入到溶液中，或者包括重复多次向溶液中加入极性有机溶剂，然后与极性有机溶剂一起蒸馏出水。 本发明还提供有机化合物的制备，其能够以高分离产率从含有有机化合物的极性有机溶剂溶液，水和必要时的化合物在接触时产生高分离产物。 用水等加速有机化合物分解的物质。