公开(公告)号：US09018182B2

公开(公告)日：2015-04-28

申请号：US13642962

申请日：2010-04-26

Applicant: Daekyung Koh ,  Seongtae Yun ,  Kyuhyun Lee ,  Hong-Kyu Lee ,  Mihee Hwang ,  Chae-Ok Yun ,  Eui-Cheol Jo

Inventor： Daekyung Koh ,  Seongtae Yun ,  Kyuhyun Lee ,  Hong-Kyu Lee ,  Mihee Hwang ,  Chae-Ok Yun ,  Eui-Cheol Jo

IPC: C12N15/113 ,  A61K35/76

CPC classification number: A61K35/76 ,  A61K35/13 ,  A61K35/761 ,  C12N2830/008

Abstract: Provided are tumor-specific promoters, oncolytic virus vectors and a pharmaceutical composition comprising the virus vector. The virus vector comprising the novel tumor-specific promoter shows excellent oncolytic effects on tumor cells, and thus it is useful for treating a cancer.

Abstract translation: 提供肿瘤特异性启动子，溶瘤病毒载体和包含病毒载体的药物组合物。 包含新型肿瘤特异性启动子的病毒载体对肿瘤细胞显示出优异的溶瘤作用，因此可用于治疗癌症。

公开(公告)号：US08290694B2

公开(公告)日：2012-10-16

申请号：US12523401

申请日：2007-12-10

Applicant: Hong Kyu Lee

Inventor： Hong Kyu Lee

IPC: G06F19/00

CPC classification number: G01C21/3691 ,  G08G1/0104 ,  G08G1/0112 ,  G08G1/0129 ,  G08G1/0133 ,  G08G1/096716 ,  G08G1/096733 ,  G08G1/096775

Abstract: Disclosed is a method for sensing a traveling state based on a speed. The method for sensing the traveling state based on the speed includes outputting a mean speed C for each link with respect to a number of total traversing times of a predetermined path, and updating a reference speed B with the outputted mean speed C, and measuring a speed A while traversing the predetermined path, and comparing the measured speed A with the updated reference speed B, thereby displaying the traveling state.

Abstract translation: 公开了一种用于基于速度感测行驶状态的方法。 用于基于速度感测行驶状态的方法包括相对于预定路径的总运行次数输出每个链路的平均速度C，并以输出的平均速度C更新参考速度B，并且测量 速度A，并且将测量速度A与更新的基准速度B进行比较，从而显示行驶状态。

公开(公告)号：US20080208173A1

公开(公告)日：2008-08-28

申请号：US11667168

申请日：2005-11-04

Applicant: Hong-Kyu Lee ,  Hee-Chan Kim

Inventor： Hong-Kyu Lee ,  Hee-Chan Kim

IPC: A61M5/142

CPC classification number: A61M5/14276 ,  A61M5/14244

Abstract: The present invention relates to an insulin pump having triple functions for the efficient regulation of a blood glucose concentration and an insulin injection system comprising the same. The insulin pump comprises an insulin syringe into which an insulin is stored, a pump to pressurize the insulin syringe in response to a programmed control signal, a control device that generates the programmed control signal to control the pump, a mode selection button to determine an insulin injection mode, and an operating button to command an insulin injection. The insulin injection mode is comprised of a base mode that continuously infuses the insulin at a basic rate to control a blood glucose concentration at a fasting, a food mode that infuses the insulin at a bulk to control the blood glucose concentration after food intake, and an activation mode that infuses the insulin in pulses for a predetermined time period. Preferably, the insulin pump complementarity cooperates with a physiological saline syringe pump that infuses physiological saline solution immediately after the infusion of the insulin at the activation mode.

Abstract translation: 本发明涉及一种胰岛素泵，其具有用于有效调节血糖浓度的三重功能和包含该胰岛素注射系统的胰岛素注射系统。 所述胰岛素泵包括胰岛素注射器，存储胰岛素的胰岛素注射器，响应于编程控制信号对胰岛素注射器加压的泵，产生编程的控制信号以控制泵的控制装置，用于确定胰岛素的模式选择按钮 胰岛素注射模式和用于控制胰岛素注射的操作按钮。 胰岛素注射模式包括基本模式，其以基本速率持续输注胰岛素以控制空腹血糖浓度，大量输注胰岛素的食物模式，以控制食物摄入后的血糖浓度;以及 一种激活模式，其将胰岛素以脉冲输入预定时间段。 优选地，胰岛素泵互补与生理盐水注射泵配合，其在激活模式下输注胰岛素之后立即输注生理盐水溶液。

公开(公告)号：US20050007905A1

公开(公告)日：2005-01-13

申请号：US10759227

申请日：2004-01-20

Applicant: Young-Pyo Lee ,  Cheol-sung Yeon ,  Hee-dong Kim ,  Hong-kyu Lee

Inventor： Young-Pyo Lee ,  Cheol-sung Yeon ,  Hee-dong Kim ,  Hong-kyu Lee

IPC: G11B7/00 ,  G11B7/125 ,  G11B7/13

CPC classification number: G11B7/13 ,  G11B7/1263

Abstract: An optical pickup used to record information on and/or reproduce information from an optical recording medium, the optical pickup including an optical module to emit a light beam; and a front photo-detector to monitor power of the light beam; wherein the optical module is coupled to the front photo-detector so that a fixed distance is maintained between the optical module and the front photo-detector.

Abstract translation: 一种用于在光学记录介质上记录信息和/或再现信息的光学拾取器，该光学拾取器包括用于发射光束的光学模块; 以及用于监视光束功率的前光检测器; 其中所述光学模块耦合到所述前光电检测器，使得在所述光学模块和所述前光电检测器之间保持固定的距离。

公开(公告)号：US20190309376A1

公开(公告)日：2019-10-10

申请号：US16417523

申请日：2019-05-20

Applicant: Hong Kyu Lee ,  UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE

Inventor： Hong Kyu Lee ,  Youngmi Kim

IPC: C12Q1/6897 ,  G01N33/53 ,  C12Q1/66

Abstract: A biological detection method for dioxin compounds in serum and its diagnostic use in predicting metabolic syndrome and related conditions are disclosed. The method of detecting dioxin compounds include obtaining a serum sample by heat-inactivating total serum obtained from a subject, preparing a transformed cell line by introducing a recombinant vector comprising a gene construct in which at least one dioxin-responsive element is operably linked to a promoter and a reporter gene into a host cell, culturing the transformed cell line with the serum sample, detecting the activation of the reporter gene in the transformed cell line, and determining that the dioxin compound is included in the serum sample when the activation of the reporter gene is detected. The serum detected by the method can be used as a surrogate serum biomarker to correlate serum content with disease factors and to predict the occurrence of disease and determine treatability.

公开(公告)号：US20130171655A1

公开(公告)日：2013-07-04

申请号：US13821779

申请日：2011-09-06

Applicant: Hong Kyu Lee ,  Youngmi Kim

Inventor： Hong Kyu Lee ,  Youngmi Kim

IPC: C12Q1/68

CPC classification number: C12Q1/6897 ,  C12Q1/66 ,  G01N33/5308 ,  G01N2800/04

Abstract: The present invention relates to a novel biological detection method for dioxins in serum and a diagnostic use thereof in metabolic syndrome and related conditions. More particularly, according to the present invention, a significant correlation between dioxin content in serum and physical variables has been confirmed by measuring luciferase activity through the use of serum as a whole and cells transformed with a recombinant vector comprising a gene construct in which a dioxin responsive element, a promoter and a reporter gene are operably linked. And there is an improvement in this method of the present invention over the conventional methods which require a preprocessing step in order to purify dioxins from serum, by which plural samples can be analyzed easily and accurately even with a very small amount of each because of the use of serum as a whole. Therefore, the detection system of the present invention which involves total serum processing in a genetically transformed cell line comprising a recombinant reporter gene whose expression is modified by dioxin compounds can be effectively used for the biological detection of dioxins in serum. This method can also be used to research the correlation between specific POPs and patient's disease factors by accurate detection of POPs such as dioxins in the serum, and further this method can be effectively used to predict the occurrence of disease and to determine treatability.

Abstract translation: 本发明涉及血清中二恶英的新型生物检测方法及其代谢综合征及相关病症的诊断用途。 更具体地，根据本发明，通过使用血清整体测量荧光素酶活性，并用包含其中二恶英的基因构建体的重组载体转化的细胞已经证实了血清中二恶英含量和物理变量之间的显着相关性 反应元件，启动子和报告基因可操作地连接。 并且本发明的这种方法相对于需要预处理步骤以便从血清中纯化二恶英的常规方法而言有所改进，即使由于这些方法也可以容易且准确地分析多个样品 使用血清作为一个整体。 因此，本发明的检测系统涉及在包含由二恶英化合物修饰的表达的重组报告基因的遗传转化细胞系中的全血清处理，可有效地用于血清中二恶英的生物检测。 该方法也可用于通过准确检测血清中二恶英等持久性有机污染物的方法研究特定持久性有机污染物和患者疾病因素之间的相关性，进一步该方法可有效用于预测疾病的发生和确定可治疗性。

公开(公告)号：US06232078B1

公开(公告)日：2001-05-15

申请号：US09630377

申请日：2000-08-01

Applicant: Hong-Kyu Lee ,  Kyong-Soo Park ,  Chan-Soo Shin

Inventor： Hong-Kyu Lee ,  Kyong-Soo Park ,  Chan-Soo Shin

IPC: C12Q168

CPC classification number: C12Q1/6883 ,  C12Q2600/158

Abstract: A method for predicting the development of type 2 diabetes before the manifestation of its symptoms in a subject, which comprises measuring the mitochondrial DNA(mtDNA) content in peripheral blood of the subject, comparing the measured mtDNA content with that of a normal control, and predicting the increased risk of development of diabetes when the subjects mtDNA content is lower than that of the normal control.

Abstract translation: 一种预测受试者症状发生之前2型糖尿病发展的方法，其包括测量受试者外周血中的线粒体DNA（mtDNA）含量，将测得的mtDNA含量与正常对照相比较，以及 当病例mtDNA含量低于正常对照时，预测糖尿病发病风险增加。

公开(公告)号：US20130065952A1

公开(公告)日：2013-03-14

申请号：US13642962

申请日：2010-04-26

Applicant: Daekyung Koh ,  Seongtae Yun ,  Kyuhyun Lee ,  Hong-Kyu Lee ,  Mihee Hwang ,  Chae-Ok Yun ,  Eui-Cheol Jo

Inventor： Daekyung Koh ,  Seongtae Yun ,  Kyuhyun Lee ,  Hong-Kyu Lee ,  Mihee Hwang ,  Chae-Ok Yun ,  Eui-Cheol Jo

IPC: C12N15/113 ,  C12N15/861 ,  A61P35/00 ,  C12N15/867 ,  C12N15/869 ,  A61K31/7088 ,  C12N15/86 ,  C12N15/864

CPC classification number: A61K35/76 ,  A61K35/13 ,  A61K35/761 ,  C12N2830/008

Abstract: Provided are tumor-specific promoters, oncolytic virus vectors and a pharmaceutical composition comprising the virus vector. The virus vector comprising the novel tumor-specific promoter shows excellent oncolytic effects on tumor cells, and thus it is useful for treating a cancer.

Abstract translation: 提供肿瘤特异性启动子，溶瘤病毒载体和包含病毒载体的药物组合物。 包含新型肿瘤特异性启动子的病毒载体对肿瘤细胞显示出优异的溶瘤作用，因此可用于治疗癌症。

公开(公告)号：US20100049429A1

公开(公告)日：2010-02-25

申请号：US12523401

申请日：2007-12-10

Applicant: Hong Kyu Lee

Inventor： Hong Kyu Lee

IPC: G01C21/10 ,  G08G1/00

CPC classification number: G01C21/3691 ,  G08G1/0104 ,  G08G1/0112 ,  G08G1/0129 ,  G08G1/0133 ,  G08G1/096716 ,  G08G1/096733 ,  G08G1/096775

Abstract: Disclosed is a method for sensing a traveling state based on a speed. The method for sensing the traveling state based on the speed includes outputting a mean speed C for each link with respect to a number of total traversing times of a predetermined path, and updating a reference speed B with the outputted mean speed C, and measuring a speed A while traversing the predetermined path, and comparing the measured speed A with the updated reference speed B, thereby displaying the traveling state.

Abstract translation: 公开了一种用于基于速度感测行驶状态的方法。 用于基于速度感测行驶状态的方法包括相对于预定路径的总运行次数输出每个链路的平均速度C，并以输出的平均速度C更新参考速度B，并且测量 速度A，并且将测量速度A与更新的基准速度B进行比较，从而显示行驶状态。

公开(公告)号：US07091829B2

公开(公告)日：2006-08-15

申请号：US10826815

申请日：2004-04-16

Applicant: Hong-Kyu Lee

Inventor： Hong-Kyu Lee

IPC: G08B5/36

CPC classification number: G08B13/19647 ,  G08B13/19656 ,  G08B13/19684 ,  G08B13/19689 ,  G08B13/19693

Abstract: The present invention relates to system and method for informing a critical situation by using network, to ask for help about present danger to Crime Prevention Center. When a user is facing a dangerous person, the user inputs images or a voice of the dangerous person to ask for help using an image input apparatus in a stealthy way. Then, the image input apparatus automatically transmits the inputted image data and/or voice data as well as present position data of the user to a security system. Thereby, the user can inform the security system of his danger even if the user is having difficulty in inputting an alarm button or is on his movement, and can operate the image input apparatus at will without limitation of position.

Abstract translation: 本发明涉及通过网络通知危急情况的系统和方法，向犯罪预防中心寻求关于当前危险的帮助。 当用户面对危险的人时，用户输入图像或危险人员的声音，以隐身的方式请求使用图像输入设备的帮助。 然后，图像输入装置自动将输入的图像数据和/或语音数据以及用户的当前位置数据发送到安全系统。 因此，即使用户难以输入报警按钮或正在进行移动，用户也可以将其危险通知给安全系统，并且能够在不受位置限制的情况下操作图像输入装置。