公开(公告)号：US09156189B2

公开(公告)日：2015-10-13

申请号：US13822983

申请日：2011-10-03

申请人： Tza-Huei Wang ,  Weijie Beh ,  Dara L. Kraitchman ,  Hsa-Quan Mao

发明人： Tza-Huei Wang ,  Weijie Beh ,  Dara L. Kraitchman ,  Hsa-Quan Mao

IPC分类号： A61B5/055 ,  B29B9/12 ,  B01J13/00 ,  A61K9/16

CPC分类号： B29B9/12 ,  A61K9/16 ,  B01J13/0052

摘要： A system for producing microbeads includes a microfluidic device defining a supply channel and a shearing channel, a microbead precursor material disposed in the supply channel, a carrier fluid disposed in the shearing channel, and a pressure distribution system fluidly connected to each of the supply channel and the shearing channel to control at least relative pressures of the microbead precursor material and the carrier fluid. The supply channel includes a check valve adapted to be subjected to a bias pressure that is sufficient to close the check valve to flow of microbead precursor material when a supply pressure of the microbead precursor material is below a threshold pressure and is open to flow of the microbead precursor material when the supply pressure of the microbead precursor material is greater than the threshold pressure. An end of the supply channel opens into the shearing channel such that the microbead precursor material is sheared into droplets by the carrier fluid flowing through the shearing channel. A pressure of the carrier fluid is less than the bias pressure. The microbead precursor material and the carrier fluid are substantially immiscible.

摘要翻译： 用于生产微珠的系统包括限定供应通道和剪切通道的微流体装置，设置在供应通道中的微珠前体材料，设置在剪切通道中的载体流体和流体连接到每个供应通道的压力分配系统 和剪切通道以控制微珠前体材料和载体流体的至少相对压力。 供应通道包括止回阀，该止回阀适于当微珠前体材料的供应压力低于阈值压力时足以关闭止回阀以流过微珠前体材料的偏压，并且对于 当微珠前体材料的供应压力大于阈值压力时，微珠前体材料。 供应通道的一端通向剪切通道，使得微珠前体材料被流过剪切通道的载体流体剪切成液滴。 载液的压力小于偏压。 微珠前体材料和载体流体基本上是不混溶的。

公开(公告)号：US20130183246A1

公开(公告)日：2013-07-18

申请号：US13822983

申请日：2011-10-03

申请人： Tza-Huei Wang ,  Weijie Beh ,  Dara L. Kraitchman ,  Hsa-Quan Mao

发明人： Tza-Huei Wang ,  Weijie Beh ,  Dara L. Kraitchman ,  Hsa-Quan Mao

IPC分类号： B29B9/12

CPC分类号： B29B9/12 ,  A61K9/16 ,  B01J13/0052

摘要： A system for producing microbeads includes a microfluidic device defining a supply channel and a shearing channel, a microbead precursor material disposed in the supply channel, a carrier fluid disposed in the shearing channel, and a pressure distribution system fluidly connected to each of the supply channel and the shearing channel to control at least relative pressures of the microbead precursor material and the carrier fluid. The supply channel includes a check valve adapted to be subjected to a bias pressure that is sufficient to close the check valve to flow of microbead precursor material when a supply pressure of the microbead precursor material is below a threshold pressure and is open to flow of the microbead precursor material when the supply pressure of the microbead precursor material is greater than the threshold pressure. An end of the supply channel opens into the shearing channel such that the microbead precursor material is sheared into droplets by the carrier fluid flowing through the shearing channel. A pressure of the carrier fluid is less than the bias pressure. The microbead precursor material and the carrier fluid are substantially immiscible.

摘要翻译： 用于生产微珠的系统包括限定供应通道和剪切通道的微流体装置，设置在供应通道中的微珠前体材料，设置在剪切通道中的载体流体和流体连接到每个供应通道的压力分配系统 和剪切通道以控制微珠前体材料和载体流体的至少相对压力。 供应通道包括止回阀，该止回阀适于当微珠前体材料的供应压力低于阈值压力时足以关闭止回阀以流过微珠前体材料的偏压，并且对于 当微珠前体材料的供应压力大于阈值压力时，微珠前体材料。 供应通道的一端通向剪切通道，使得微珠前体材料被流过剪切通道的载体流体剪切成液滴。 载液的压力小于偏压。 微珠前体材料和载体流体基本上是不混溶的。