公开(公告)号：US10081676B2

公开(公告)日：2018-09-25

申请号：US14902394

申请日：2014-07-03

申请人： IMMUNOQURE AG

发明人： Adrian Hayday ,  Kai Kisand ,  Kai Krohn ,  Annalisa Macagno ,  Shimobi Onuoha ,  Paert Peterson ,  Mike Rothe ,  Martin Woodward ,  Syeda F. Y. Haque

IPC分类号： A61K39/395 ,  C12N15/09 ,  C07K16/24 ,  G01N33/68 ,  A61K39/00

摘要： Provided are novel IL-32 binding molecules of human origin, particularly human anti-IL-32 antibodies as well as IL-32 binding fragments, derivatives and variants thereof. In addition, pharmaceutical compositions, kits and methods for use in diagnosis and therapy are described.

公开(公告)号：US20170051053A1

公开(公告)日：2017-02-23

申请号：US15258263

申请日：2016-09-07

申请人： IMMUNOQURE AG

发明人： Adrian HAYDAY ,  Kai KROHN ,  Annamari RANKI ,  Part PETERSON ,  Kai KISAND ,  Edward STUART ,  Annalisa MACAGNO ,  Shimobi ONUOHA

IPC分类号： C07K16/24 ,  G01N33/68 ,  G01N33/569

CPC分类号： C07K16/244 ,  A61K2039/505 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92

摘要： Provided are novel binding molecules of human origin, particularly human antibodies as well as fragments, derivatives and variants thereof that recognize antigens such as native endogenous proteins associated with, e.g., immune response, autoimmune disorders, inflammatory diseases, metabolic disorders, vascular function, neurodegenerative diseases or tumors. More particularly, a human Auto-Immunosome and corresponding monoclonal antibody reservoir are provided. In addition, pharmaceutical compositions, kits and methods for use in diagnosis and therapy of are described.

摘要翻译： 提供了人源的新型结合分子，特别是人抗体以及其识别抗原的片段，衍生物和变体，例如与免疫应答，自身免疫性疾病，炎性疾病，代谢紊乱，血管功能，神经变性相关的天然内源蛋白 疾病或肿瘤。 更具体地，提供人自身免疫体和相应的单克隆抗体储库。 此外，描述了用于诊断和治疗的药物组合物，试剂盒和方法。

公开(公告)号：US10941198B2

公开(公告)日：2021-03-09

申请号：US16133352

申请日：2018-09-17

申请人： IMMUNOQURE AG

发明人： Syeda F. Y. Haque ,  Adrian Hayday ,  Kai Kisand ,  Kai Krohn ,  Annalisa Macagno ,  Steffen Meyer ,  Paert Peterson ,  Mike Rothe ,  Philip Vlaicu ,  Martin Woodward

IPC分类号： C07K16/24 ,  G01N33/564 ,  G01N33/68 ,  A61K47/68

摘要： Provided are novel IFB-a binding molecules of human origin, particularly human-derived anti-IFN-α antibodies as well as IFN-α binding fragments, derivatives and variants thereof. In addition, pharmaceutical compositions, kits, and methods for use in diagnosis and therapy are described.

公开(公告)号：US20170189524A1

公开(公告)日：2017-07-06

申请号：US15321842

申请日：2015-07-03

申请人： IMMUNOQURE AG

发明人： Steffen MEYER ,  Philip VLAICU ,  Annalisa MACAGNO ,  Part PETERSON ,  Kai KISAND

IPC分类号： A61K39/395 ,  G01N33/50 ,  G01N33/68 ,  C07K16/24

CPC分类号： A61K39/3955 ,  C07K16/244 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  G01N33/5008 ,  G01N33/6863 ,  G01N2500/10

摘要： Provided are novel interleukin-20 (IL-20) binding molecules of human origin, particularly human-derived anti-human IL-20 antibodies as well as IL-20 binding fragments, derivatives and biotechnological derivatives thereof. In addition, pharmaceutical compositions, kits and methods for use in diagnosis and therapy are described. In addition, a cellular enzyme-linked ligand binding assay is described for isolating antibodies and biotechnological derivatives thereof for pharmaceutical use, in particular recombinant human-derived anti-human cytokine antibodies.

公开(公告)号：US20140363422A1

公开(公告)日：2014-12-11

申请号：US14369467

申请日：2013-01-02

申请人： IMMUNOQURE AG

发明人： Adrian Hayday ,  Kai Krohn ,  Annamari Ranki ,  Part Peterson ,  Kai Kisand ,  Edward Stuart ,  Annalisa MacAgno ,  Shimobi Onuoha

IPC分类号： C07K16/24 ,  A61K45/06 ,  C07K16/42 ,  A61K39/395 ,  G01N33/68

CPC分类号： C07K16/244 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/00 ,  C07K16/065 ,  C07K16/18 ,  C07K16/4241 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/76 ,  C07K2317/92 ,  C12N2501/599 ,  G01N33/56972 ,  G01N33/6869 ,  G01N2333/54

摘要： Provided are novel binding molecules of human origin, particularly human antibodies as well as fragments, derivatives and variants thereof that recognize antigens such as native endogenous proteins associated with, e.g., immune response, autoimmune disorders, inflammatory diseases, metabolic disorders, vascular function, neurodegenerative diseases or tumors. More particularly, a human Auto-Immunosome and corresponding monoclonal antibody reservoir are provided. In addition, pharmaceutical compositions, kits and methods for use in diagnosis and therapy of are described.

摘要翻译： 提供了人源的新型结合分子，特别是人抗体以及其识别抗原的片段，衍生物和变体，例如与免疫应答，自身免疫性疾病，炎性疾病，代谢紊乱，血管功能，神经变性相关的天然内源蛋白 疾病或肿瘤。 更具体地，提供人自身免疫体和相应的单克隆抗体储库。 此外，描述了用于诊断和治疗的药物组合物，试剂盒和方法。

公开(公告)号：US11945861B2

公开(公告)日：2024-04-02

申请号：US17154350

申请日：2021-01-21

申请人： IMMUNOQURE AG

发明人： Syeda F. Y. Haque ,  Adrian Hayday ,  Kai Kisand ,  Kai Krohn ,  Annalisa Macagno ,  Steffen Meyer ,  Paert Peterson ,  Mike Rothe ,  Philip Vlaicu ,  Martin Woodward

IPC分类号： C07K16/24 ,  A61K47/68 ,  G01N33/564 ,  G01N33/68

CPC分类号： C07K16/249 ,  A61K47/6845 ,  G01N33/564 ,  G01N33/6866 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/76 ,  C07K2317/92 ,  G01N2333/56

摘要： Provided are novel IFB-a binding molecules of human origin, particularly human-derived anti-IFN-α antibodies as well as IFN-α binding fragments, derivatives and variants thereof. In addition, pharmaceutical compositions, kits, and methods for use in diagnosis and therapy are described.

公开(公告)号：US10975144B2

公开(公告)日：2021-04-13

申请号：US16107889

申请日：2018-08-21

申请人： IMMUNOQURE AG

发明人： Adrian Hayday ,  Kai Kisand ,  Kai Krohn ,  Annalisa Macagno ,  Shimobi Onuoha ,  Paert Peterson ,  Mike Rothe ,  Martin Woodward ,  Syeda F. Y. Haque

IPC分类号： C12N15/09 ,  C07K16/24 ,  A61P37/00 ,  G01N33/68 ,  A61K39/00

摘要： Provided are novel IL-32 binding molecules of human origin, particularly human anti-IL-32 antibodies as well as IL-32 binding fragments, derivatives and variants thereof. In addition, pharmaceutical compositions, kits and methods for use in diagnosis and therapy are described.

公开(公告)号：US20170051055A1

公开(公告)日：2017-02-23

申请号：US14902409

申请日：2014-07-03

申请人： IMMUNOQURE AG

发明人： Syeda F.Y. HAQUE ,  Adrian HAYDAY ,  Kai KISAND ,  Kai KROHN ,  Annalisa MACAGNO ,  Steffen MEYER ,  Paert PETERSON ,  Mike ROTHE ,  Philip VLAICU ,  Martin WOODWARD

IPC分类号： C07K16/24 ,  G01N33/564 ,  G01N33/68

CPC分类号： C07K16/249 ,  A61K47/6845 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/564 ,  G01N33/6866 ,  G01N2333/56

摘要： Provided are novel IFN-α binding molecules of human origin, particularly human-derived anti-IFN-α antibodies as well as IFN-α binding fragments, derivatives and variants thereof. In addition, pharmaceutical compositions, kits and methods for use in diagnosis and therapy are described.

摘要翻译： 提供了人源的新型IFN-α结合分子，特别是人源抗体IFN-α抗体以及IFN-α结合片段，其衍生物和变体。 此外，描述了用于诊断和治疗的药物组合物，试剂盒和方法。

公开(公告)号：US20190112367A1

公开(公告)日：2019-04-18

申请号：US16107889

申请日：2018-08-21

申请人： IMMUNOQURE AG

发明人： Adrian Hayday ,  Kai Kisand ,  Kai Krohn ,  Annalisa Macagno ,  Shimobi Onuoha ,  Paert Peterson ,  Mike Rothe ,  Martin Woodward ,  Syeda F. Y. Haque

IPC分类号： C07K16/24 ,  G01N33/68

摘要： Provided are novel IL-32 binding molecules of human origin, particularly human anti-IL-32 antibodies as well as IL-32 binding fragments, derivatives and variants thereof. In addition, pharmaceutical compositions, kits and methods for use in diagnosis and therapy are described.

公开(公告)号：US20190071499A1

公开(公告)日：2019-03-07

申请号：US16133352

申请日：2018-09-17

申请人： IMMUNOQURE AG

发明人： Syeda F. Y. HAQUE ,  Adrian HAYDAY ,  Kai KISAND ,  Kai KROHN ,  Annalisa MACAGNO ,  Steffen MEYER ,  Paert PETERSON ,  Mike ROTHE ,  Philip VLAICU ,  Martin WOODWARD

IPC分类号： C07K16/24 ,  A61K47/68 ,  G01N33/68 ,  G01N33/564

摘要： Provided are novel IFB-a binding molecules of human origin, particularly human-derived anti-IFN-α antibodies as well as IFN-α binding fragments, derivatives and variants thereof. In addition, pharmaceutical compositions, kits, and methods for use in diagnosis and therapy are described.