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公开(公告)号：US10941198B2
公开(公告)日：2021-03-09
申请号：US16133352
申请日：2018-09-17
申请人： IMMUNOQURE AG
发明人： Syeda F. Y. Haque , Adrian Hayday , Kai Kisand , Kai Krohn , Annalisa Macagno , Steffen Meyer , Paert Peterson , Mike Rothe , Philip Vlaicu , Martin Woodward
IPC分类号： C07K16/24 , G01N33/564 , G01N33/68 , A61K47/68
摘要： Provided are novel IFB-a binding molecules of human origin, particularly human-derived anti-IFN-α antibodies as well as IFN-α binding fragments, derivatives and variants thereof. In addition, pharmaceutical compositions, kits, and methods for use in diagnosis and therapy are described.
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公开(公告)号：US10081676B2
公开(公告)日：2018-09-25
申请号：US14902394
申请日：2014-07-03
申请人： IMMUNOQURE AG
发明人： Adrian Hayday , Kai Kisand , Kai Krohn , Annalisa Macagno , Shimobi Onuoha , Paert Peterson , Mike Rothe , Martin Woodward , Syeda F. Y. Haque
IPC分类号： A61K39/395 , C12N15/09 , C07K16/24 , G01N33/68 , A61K39/00
摘要： Provided are novel IL-32 binding molecules of human origin, particularly human anti-IL-32 antibodies as well as IL-32 binding fragments, derivatives and variants thereof. In addition, pharmaceutical compositions, kits and methods for use in diagnosis and therapy are described.
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公开(公告)号：US11945861B2
公开(公告)日：2024-04-02
申请号：US17154350
申请日：2021-01-21
申请人： IMMUNOQURE AG
发明人： Syeda F. Y. Haque , Adrian Hayday , Kai Kisand , Kai Krohn , Annalisa Macagno , Steffen Meyer , Paert Peterson , Mike Rothe , Philip Vlaicu , Martin Woodward
IPC分类号： C07K16/24 , A61K47/68 , G01N33/564 , G01N33/68
CPC分类号： C07K16/249 , A61K47/6845 , G01N33/564 , G01N33/6866 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/76 , C07K2317/92 , G01N2333/56
摘要： Provided are novel IFB-a binding molecules of human origin, particularly human-derived anti-IFN-α antibodies as well as IFN-α binding fragments, derivatives and variants thereof. In addition, pharmaceutical compositions, kits, and methods for use in diagnosis and therapy are described.
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4.发明授权公开(公告)号：US10975144B2
公开(公告)日：2021-04-13
申请号：US16107889
申请日：2018-08-21
申请人： IMMUNOQURE AG
发明人： Adrian Hayday , Kai Kisand , Kai Krohn , Annalisa Macagno , Shimobi Onuoha , Paert Peterson , Mike Rothe , Martin Woodward , Syeda F. Y. Haque
摘要： Provided are novel IL-32 binding molecules of human origin, particularly human anti-IL-32 antibodies as well as IL-32 binding fragments, derivatives and variants thereof. In addition, pharmaceutical compositions, kits and methods for use in diagnosis and therapy are described.
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公开(公告)号：US20190112367A1
公开(公告)日：2019-04-18
申请号：US16107889
申请日：2018-08-21
申请人： IMMUNOQURE AG
发明人： Adrian Hayday , Kai Kisand , Kai Krohn , Annalisa Macagno , Shimobi Onuoha , Paert Peterson , Mike Rothe , Martin Woodward , Syeda F. Y. Haque
摘要： Provided are novel IL-32 binding molecules of human origin, particularly human anti-IL-32 antibodies as well as IL-32 binding fragments, derivatives and variants thereof. In addition, pharmaceutical compositions, kits and methods for use in diagnosis and therapy are described.
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公开(公告)号：US10112995B2
公开(公告)日：2018-10-30
申请号：US14902409
申请日：2014-07-03
申请人： IMMUNOQURE AG
发明人： Syeda F. Y. Haque , Adrian Hayday , Kai Kisand , Kai Krohn , Annalisa Macagno , Steffen Meyer , Paert Peterson , Mike Rothe , Philip Vlaicu , Martin Woodward
IPC分类号： C07K16/24 , C07H21/04 , G01N33/564 , G01N33/68 , A61K47/48
摘要： Provided are novel IFB-a binding molecules of human origin, particularly human-derived anti-IFN-α antibodies as well as IFN-α binding fragments, derivatives and variants thereof. In addition, pharmaceutical compositions, kits, and methods for use in diagnosis and therapy are described.
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公开(公告)号：US10131709B2
公开(公告)日：2018-11-20
申请号：US15258263
申请日：2016-09-07
申请人： IMMUNOQURE AG
发明人： Adrian Hayday , Kai Krohn , Annamari Ranki , Part Peterson , Kai Kisand , Edward Stuart , Annalisa Macagno , Shimobi Onuoha
摘要： Provided are novel binding molecules of human origin, particularly human antibodies as well as fragments, derivatives and variants thereof that recognize antigens such as native endogenous proteins associated with, e.g., immune response, autoimmune disorders, inflammatory diseases, metabolic disorders, vascular function, neurodegenerative diseases or tumors. More particularly, a human Auto-Immunosome and corresponding monoclonal antibody reservoir are provided. In addition, pharmaceutical compositions, kits and methods for use in diagnosis and therapy of are described.
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公开(公告)号：US09957319B2
公开(公告)日：2018-05-01
申请号：US14368749
申请日：2013-01-02
申请人： IMMUNOQURE AG
发明人： Adrian Hayday , Kai Krohn , Annamari Ranki , Part Peterson , Kai Kisand , Edward Stuart , Annalisa Macagno
IPC分类号： C07K16/24 , C07K16/06 , C07K16/18 , C07K16/00 , G01N33/569 , A61K39/395 , A61K45/06 , C07K16/42 , G01N33/68 , A61K39/00
CPC分类号： C07K16/244 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K16/00 , C07K16/065 , C07K16/18 , C07K16/4241 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/76 , C07K2317/92 , C12N2501/599 , G01N33/56972 , G01N33/6869 , G01N2333/54
摘要： Provided is a novel method of isolating and producing human antibodies with desired specificity from human B cells. In particular, a method of isolating human antibodies from memory B cells obtained from patients which suffer from a disease which is caused by or involves activation of the immune system, for example autoimmune and inflammatory disorders is described.
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公开(公告)号：US20140335098A1
公开(公告)日：2014-11-13
申请号：US14368749
申请日：2013-01-02
申请人： IMMUNOQURE AG
发明人： Adrian Hayday , Kai Krohn , Annamari Ranki , Part Peterson , Kai Kisand , Edward Stuart , Annalisa Macagno
IPC分类号： C07K16/00 , G01N33/569
CPC分类号： C07K16/244 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K16/00 , C07K16/065 , C07K16/18 , C07K16/4241 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/76 , C07K2317/92 , C12N2501/599 , G01N33/56972 , G01N33/6869 , G01N2333/54
摘要： Provided is a novel method of isolating and producing human antibodies with desired specificity from human B cells. In particular, a method of isolating human antibodies from memory B cells obtained from patients which suffer from a disease which is caused by or involves activation of the immune system, for example autoimmune and inflammatory disorders is described.
摘要翻译： 提供了一种从人B细胞分离和产生具有所需特异性的人抗体的新方法。 特别地，描述了从患有由免疫系统引起或涉及激活免疫系统（例如自身免疫和炎症性疾病）的疾病的患者获得的记忆B细胞中分离人抗体的方法。
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