公开(公告)号：US20230310421A1

公开(公告)日：2023-10-05

申请号：US17996113

申请日：2021-04-14

Applicant: ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. ,  UNIVERSITA' DEGLI STUDI DI MILANO

Inventor： Piergiuseppe PELICCI ,  Saverio MINUCCI ,  Fabio SANTORO ,  Mauro ROMANENGHI ,  Luca MAZZARELLA ,  Paul-Edward MASSA ,  Bruno ACHUTTI DUSO

IPC: A61K31/4965 ,  A61K45/06 ,  A61K31/4409 ,  A61K31/4245 ,  A61P31/14

CPC classification number: A61K31/4965 ,  A61K45/06 ,  A61K31/4409 ,  A61K31/4245 ,  A61P31/14

Abstract: The present invention relates to LSD1 inhibitors for use in the treatment and/or prevention of a viral infection caused by and/or associated with RNA viruses, preferably Coronaviridae. The LSD1 inhibitors are able to inhibit or prevent the viral induced increased expression of inflammatory cytokines while sparing the expression of Interferon and Interferon-Stimulated Genes. The present invention further concerns a combination and a pharmaceutical composition including the molecules or combinations thereof.

公开(公告)号：US11369577B2

公开(公告)日：2022-06-28

申请号：US15529886

申请日：2015-11-25

Applicant: IEO—Istituto Europeo di Oncologia S.r.l. ,  I.R.C.C.S. “Casa Sollievo della Sofferenza” ,  Università degli Studi di Milano

Inventor： Giuseppe Testa ,  Sina Atashpazgargari ,  Antonio Adamo ,  Pierre-Luc Germain ,  Giuseppe Merla ,  Giuseppe D'Agostino ,  Matteo Zanella

IPC: A61K31/00 ,  G01N33/50 ,  C12N5/074 ,  C12Q1/6881 ,  C12Q1/6883 ,  A61K31/421 ,  A61K31/135 ,  C12Q1/6897

Abstract: The present invention relates to iPSC produced from fibroblast obtained from a subject affected by a neurodevelopmental disorder entailing intellectual disability (ID) and/or a disorder belonging to the Autism Spectrum Disorder (ASD) and/or Schizophrenia (SZ) and uses thereof. The present invention also relates to a cortical neural progenitor cell or a terminally differentiated cortical glutamatergic or gabaergic neuronal cell or a neural crest stem cell line, a mesenchymal stem cell line produced from the iPSC or iPSC line. The invention also relates to method for identifying a compound for the treatment and/or prevention of a neurodevelopmental disorder entailing intellectual disability (ID) and/or a disorder belonging to the Autism Spectrum Disorder (ASD) and/or Schizophrenia (SZ) and to a LSD1 inhibitor or a HDAC2 inhibitor for use in the treatment of such disorders.

公开(公告)号：US10980777B2

公开(公告)日：2021-04-20

申请号：US16640030

申请日：2018-08-17

Applicant: Istituto Europeo di Oncologia S.r.l.

Inventor： Mario Varasi ,  Anna Cappa ,  Paola Vianello ,  Loris Moretti ,  Luca Sartori ,  Ciro Mercurio

IPC: A61K31/407 ,  A61K45/06 ,  C07D495/04

Abstract: The present application relates to compounds of formula (I), wherein A, R, R1, and R2 are as defined in the specification, pharmaceutical compositions containing such compounds and to their use in therapy.

公开(公告)号：US20200289463A1

公开(公告)日：2020-09-17

申请号：US16640030

申请日：2018-08-17

Applicant: Istituto Europeo di Oncologia S.r.l.

Inventor： Mario VARASI ,  Anna CAPPA ,  Paola VIANELLO ,  Loris MORETTI ,  Luca SARTORI ,  Ciro MERCURIO

IPC: A61K31/407 ,  A61K45/06 ,  C07D495/04

Abstract: The present application relates to compounds of formula (I), wherein A, R, R1, and R2 are as defined in the specification, pharmaceutical compositions containing such compounds and to their use in therapy.

公开(公告)号：US10562914B2

公开(公告)日：2020-02-18

申请号：US16301875

申请日：2017-05-18

Applicant: Istituto Europeo di Oncologia S.r.l.

Inventor： Paola Vianello ,  Alessia Romussi ,  Anna Cappa ,  Paolo Trifiro' ,  Mario Varasi ,  Luca Sartori ,  Ciro Mercurio

IPC: C07D495/04 ,  A61K31/4178 ,  A61P3/04 ,  A61P35/00

Abstract: The present invention relates to imidazole derivatives of Formula (I), wherein A, R, R1, and R2 are as defined in the specification, pharmaceutical compositions containing such compounds and to their use in therapy.

公开(公告)号：US20190152987A1

公开(公告)日：2019-05-23

申请号：US16301875

申请日：2017-05-18

Applicant: Istituto Europeo di Oncologia S.r.l.

Inventor： Paola VIANELLO ,  Alessia ROMUSSI ,  Anna CAPPA ,  Paolo TRIFIRO' ,  Mario VARASI ,  Luca SARTORI ,  Ciro MERCURIO

IPC: C07D495/04 ,  A61P3/04 ,  A61P35/00

CPC classification number: C07D495/04 ,  A61P3/04 ,  A61P35/00

Abstract: The present invention relates to imidazole derivatives of Formula (I), wherein A, R, R1, and R2 are as defined in the specification, pharmaceutical compositions containing such compounds and to their use in therapy.

公开(公告)号：US20250101532A1

公开(公告)日：2025-03-27

申请号：US18904935

申请日：2024-10-02

Applicant: Istituto Europeo di Oncologia S.r.l. ,  Fondazione Istituto Firc di Oncologia Molecolare (IFOM) ,  Universita degli Studi di Milano (University of Milan)

Inventor： Pier Paolo DI FIORE ,  Salvatore PECE ,  Manuela VECCHI ,  Stefano CONFALONIERI

IPC: C12Q1/6886 ,  G16B5/00 ,  G16B40/00

Abstract: The present invention relates to refined prognostic clinical tools, methods, and kits for the evaluation of risk and treatment of distant recurrence in ER+/HER2− breast cancer patients.

公开(公告)号：US20240425848A1

公开(公告)日：2024-12-26

申请号：US18274079

申请日：2022-07-22

Applicant: Ospedale San Raffaele S.r..l. ,  Fondazione Centro San Raffaele ,  Istituto Europeo Di Oncologia S.r.l.

Inventor： Giovanni Tonon ,  Davide Cittaro ,  Martina Tedesco ,  Francesca Giannese ,  Dejan Lazarevic ,  Sebastiano Pasqualato

IPC: C12N15/10 ,  C12N9/12

Abstract: The present invention relates to an engineered transposase comprising a transposase operably linked to a polypeptide that binds to a component of heterochromatin. The present invention further relates to an engineered transposome complex comprising an oligonucleotide and an engineered transposase according to the invention. The present invention also relates to methods and uses of the engineered transposase of the invention and engineered transposome of the invention for making a DNA sequence library or libraries and for DNA sequencing.

公开(公告)号：US20230143295A1

公开(公告)日：2023-05-11

申请号：US17907601

申请日：2021-05-07

Applicant: Istituto Europeo di Oncologia S.r.l. ,  Universita degli Studi di Milano

Inventor： Pier Paolo DI FIORE ,  Salvatore PECE

IPC: C12Q1/6886 ,  G16H50/30

CPC classification number: C12Q1/6886 ,  G16H50/30 ,  C12Q2600/118 ,  C12Q2600/158

Abstract: The present invention relates to methods and kits for the evaluation of risk and treatment of distant recurrence of breast cancer in a subject. The methods and kits can comprise combining the measured expression levels of a subset of genes selected from a 20-gene signature with tumor size and nodal status to determine the risk of distant recurrence.

公开(公告)号：US20220370608A1

公开(公告)日：2022-11-24

申请号：US17629139

申请日：2020-07-22

Applicant: HUMANITAS MIRASOLE S.P.A. ,  HUMANITAS UNIVERSITY ,  ISTITUTO EUROPEO DI ONCOLOGIA S.R.L.

Inventor： Giuseppe PENNA ,  Maria RESCIGNO ,  Abbass DARWICH

IPC: A61K39/395 ,  A61P35/00 ,  G01N33/574

Abstract: The present invention relates to a suppressor or inhibitor of the expression and/or the activity of Chitinase 3-like 1 (CHI3L1) for use in the prevention and/or treatment of tumors, wherein said tumors are resistant to antibody-dependent cell-mediated cytotoxicity (ADCC) dependent therapies and/or for use in reducing the risk of developing resistance to antibody-dependent cell-mediated cytotoxicity (ADCC) dependent therapies.