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公开(公告)号：US20100222224A1
公开(公告)日：2010-09-02
申请号：US12584341
申请日：2009-09-03
CPC分类号： G01N33/5438 , B01J2219/00605 , B01J2219/00725 , B01J2219/0074
摘要： The present invention is directed to a method and apparatus that satisfies the need for a bioelectronic tongue for food allergy detection. The method of detecting concentration of food allergen incorporates antibodies into an electronic tongue to create a bioelectronic tongue. Additionally the method uses impedance, capacitance, and/or other related electrochemical methods for detecting analyte in complex media. Furthermore the method additionally includes methods to subtract out non-specific interactions. The method also subtracts non-specific interactions. The device/apparatus is a Bioelectronic Tongue for detecting allergen in diluted food samples. The device includes: a sensor array; an impedance or capacitance analyzer; a preprocessor; a feature extractor; a pattern recognizer; and an output device indicating an allergen concentration. In order to implement the method of detecting food allergens on a bioelectronic tongue a computer readable medium containing an executable program is used for performing the analysis of a food sample. The executable program performs the acts of: preprocessing data from an impedance analyzer; extracting a feature pattern; recognizing a pattern of features of data representing a concentration of food allergen contained is the food sample; and outputs allergen concentration data.
摘要翻译： 本发明涉及满足食物过敏检测生物电子舌的需要的方法和装置。 检测食物过敏原浓度的方法将抗体结合到电子舌中以产生生物电子舌。 此外，该方法使用阻抗，电容和/或其他相关的电化学方法来检测复合介质中的分析物。 此外，该方法还包括减去非特异性相互作用的方法。 该方法还减去非特异性相互作用。 该设备/设备是用于检测稀释食品样品中的变应原的生物电子舌。 该装置包括：传感器阵列; 阻抗或电容分析仪; 预处理器 特征提取器 模式识别器 以及表示变应原浓度的输出装置。 为了实现在生物电子舌上检测食物过敏原的方法，使用包含可执行程序的计算机可读介质来进行食物样品的分析。 可执行程序执行以下动作：从阻抗分析器预处理数据; 提取特征模式; 识别表示食物过敏原浓度的数据特征的模式是食物样品; 并输出过敏原浓度数据。
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公开(公告)号：US20090187167A1
公开(公告)日：2009-07-23
申请号：US12337417
申请日：2008-12-17
CPC分类号： A61M5/1723 , A61B17/205 , A61M5/14276 , A61M5/158 , A61M37/0015 , A61M2005/14208 , A61M2005/1585 , A61M2037/0023 , A61M2037/003 , A61M2037/0038 , A61M2037/0061
摘要： In one embodiment, an IDDC system utilizes an intelligent therapeutic agent delivery system comprised of one, but more likely an array of “cells” containing therapeutic agent(s) and/or diagnostic agents(s); an integrated bio-sensing system designed to sample and analyze biological materials using multiple sensors that include both hardware and software components. The software component involves biomedical signal processing to analyze complex liquid mixtures and a microcontrollers) acts as interface to the biosensors, to the therapeutic delivery elements, and to a communications system(s) for the purpose of controlling the amount of therapeutic agent to deliver and also to provide information in a useful form to interested parties on the progress of therapy and compliance thereto. The synergistic effect of combining the above describe elements is expected to dramatically improve patient compliance with prescribed therapy, quality and timeliness of care provided by physicians, and at the same time reduce the cost of providing effective healthcare to IDDC system users, thereby improving profitability for Managed Care organizations and pharmaceutical companies utilizing the system.
摘要翻译： 在一个实施方案中，IDDC系统利用智能治疗剂递送系统，其包括一个但更可能包含含有治疗剂和/或诊断剂的“细胞”阵列; 一个集成的生物传感系统，旨在使用包含硬件和软件组件的多个传感器对生物材料进行采样和分析。 软件组件涉及生物医学信号处理以分析复杂的液体混合物和微控制器）作为生物传感器，治疗递送元件和通信系统的界面，用于控制递送的治疗剂的量和 还向利害关系方提供有关治疗进展情况及其遵守情况的信息。 预期结合上述要素的协同效应将大大提高患者对规定治疗的依从性，医生提供的护理质量和及时性，同时降低向IDDC系统用户提供有效保健的成本，从而提高 管理保健组织和制药公司利用该系统。
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公开(公告)号：US09201068B2
公开(公告)日：2015-12-01
申请号：US12584341
申请日：2009-09-03
IPC分类号： G01N33/53 , G01N33/543
CPC分类号： G01N33/5438 , B01J2219/00605 , B01J2219/00725 , B01J2219/0074
摘要： The present invention is directed to a method and apparatus that satisfies the need for a bioelectronic tongue for food allergy detection. The method of detecting concentration of food allergen incorporates antibodies into an electronic tongue to create a bioelectronic tongue. Additionally the method uses impedance, capacitance, and/or other related electrochemical methods for detecting analyte in complex media. Furthermore the method additionally includes methods to subtract out non-specific interactions. The method also subtracts non-specific interactions. The device/apparatus is a Bioelectronic Tongue for detecting allergen in diluted food samples. The device includes: a sensor array; an impedance or capacitance analyzer; a preprocessor; a feature extractor; a pattern recognizer; and an output device indicating an allergen concentration. In order to implement the method of detecting food allergens on a bioelectronic tongue a computer readable medium containing an executable program is used for performing the analysis of a food sample. The executable program performs the acts of: preprocessing data from an impedance analyzer; extracting a feature pattern; recognizing a pattern of features of data representing a concentration of food allergen contained is the food sample; and outputs allergen concentration data.
摘要翻译： 本发明涉及满足食物过敏检测生物电子舌的需要的方法和装置。 检测食物过敏原浓度的方法将抗体结合到电子舌中以产生生物电子舌。 此外，该方法使用阻抗，电容和/或其他相关的电化学方法来检测复合介质中的分析物。 此外，该方法还包括减去非特异性相互作用的方法。 该方法还减去非特异性相互作用。 该设备/设备是用于检测稀释食品样品中的变应原的生物电子舌。 该装置包括：传感器阵列; 阻抗或电容分析仪; 预处理器 特征提取器 模式识别器 以及表示变应原浓度的输出装置。 为了实现在生物电子舌上检测食物过敏原的方法，使用包含可执行程序的计算机可读介质来进行食物样品的分析。 可执行程序执行以下动作：从阻抗分析器预处理数据; 提取特征模式; 识别表示食物过敏原浓度的数据特征的模式是食物样品; 并输出过敏原浓度数据。
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公开(公告)号：US09022973B2
公开(公告)日：2015-05-05
申请号：US12337417
申请日：2008-12-17
CPC分类号： A61M5/1723 , A61B17/205 , A61M5/14276 , A61M5/158 , A61M37/0015 , A61M2005/14208 , A61M2005/1585 , A61M2037/0023 , A61M2037/003 , A61M2037/0038 , A61M2037/0061
摘要： In one embodiment, an IDDC system utilizes an intelligent therapeutic agent delivery system comprised of one, but more likely an array of “cells” containing therapeutic agent(s) and/or diagnostic agents(s); an integrated bio-sensing system designed to sample and analyze biological materials using multiple sensors that include both hardware and software components. The software component involves biomedical signal processing to analyze complex liquid mixtures and a microcontrollers) acts as interface to the biosensors, to the therapeutic delivery elements, and to a communications system(s) for the purpose of controlling the amount of therapeutic agent to deliver and also to provide information in a useful form to interested parties on the progress of therapy and compliance thereto. The synergistic effect of combining the above describe elements is expected to dramatically improve patient compliance with prescribed therapy, quality and timeliness of care provided by physicians, and at the same time reduce the cost of providing effective healthcare to IDDC system users, thereby improving profitability for Managed Care organizations and pharmaceutical companies utilizing the system.
摘要翻译： 在一个实施方案中，IDDC系统利用智能治疗剂递送系统，其包括一个但更可能包含含有治疗剂和/或诊断剂的“细胞”阵列; 一个集成的生物传感系统，旨在使用包含硬件和软件组件的多个传感器对生物材料进行采样和分析。 软件组件涉及生物医学信号处理以分析复杂的液体混合物和微控制器）作为生物传感器，治疗递送元件和通信系统的界面，用于控制递送的治疗剂的量和 还向利害关系方提供有关治疗进展情况及其遵守情况的信息。 预期结合上述要素的协同效应将大大提高患者对规定治疗的依从性，医生提供的护理质量和及时性，同时降低向IDDC系统用户提供有效保健的成本，从而提高 管理保健组织和制药公司利用该系统。
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