-
1.
公开(公告)号:US20170202789A1
公开(公告)日:2017-07-20
申请号:US15326016
申请日:2015-07-16
申请人: Frederick A. Sexton , Timothy S. Tracy , Sitaraman Krishnan , Vankat K. Vendra , James M. Myrick
发明人: Frederick A. Sexton , Timothy S. Tracy , Sitaraman Krishnan , Vankat K. Vendra , James M. Myrick
IPC分类号: A61K31/155 , A61K31/198 , A61K31/22 , A61K9/16 , A61K31/519 , A61K31/522 , A61K31/7072 , A61K31/7004 , A61K31/4164
CPC分类号: A61K31/155 , A61K9/1652 , A61K31/198 , A61K31/22 , A61K31/4164 , A61K31/519 , A61K31/522 , A61K31/7004 , A61K31/7072
摘要: The present invention relates to methods and compositions for improved drug bioavailability and disease treatment, including treatment of diseases related to hormone modulation or CNS function. In certain embodiments, the instant invention provides methods for hormone modulation or improving CNS function, comprising administering to a subject in need thereof a composition comprising one or more hydrogel particles, wherein the one or more hydrogel particles are non-toxic and incorporate at least one active agent, wherein the one or more hydrogel particles release the active agent in a time-controlled and sustained manner in vivo.
-
2.
公开(公告)号:US09022973B2
公开(公告)日:2015-05-05
申请号:US12337417
申请日:2008-12-17
CPC分类号: A61M5/1723 , A61B17/205 , A61M5/14276 , A61M5/158 , A61M37/0015 , A61M2005/14208 , A61M2005/1585 , A61M2037/0023 , A61M2037/003 , A61M2037/0038 , A61M2037/0061
摘要: In one embodiment, an IDDC system utilizes an intelligent therapeutic agent delivery system comprised of one, but more likely an array of “cells” containing therapeutic agent(s) and/or diagnostic agents(s); an integrated bio-sensing system designed to sample and analyze biological materials using multiple sensors that include both hardware and software components. The software component involves biomedical signal processing to analyze complex liquid mixtures and a microcontrollers) acts as interface to the biosensors, to the therapeutic delivery elements, and to a communications system(s) for the purpose of controlling the amount of therapeutic agent to deliver and also to provide information in a useful form to interested parties on the progress of therapy and compliance thereto. The synergistic effect of combining the above describe elements is expected to dramatically improve patient compliance with prescribed therapy, quality and timeliness of care provided by physicians, and at the same time reduce the cost of providing effective healthcare to IDDC system users, thereby improving profitability for Managed Care organizations and pharmaceutical companies utilizing the system.
摘要翻译: 在一个实施方案中,IDDC系统利用智能治疗剂递送系统,其包括一个但更可能包含含有治疗剂和/或诊断剂的“细胞”阵列; 一个集成的生物传感系统,旨在使用包含硬件和软件组件的多个传感器对生物材料进行采样和分析。 软件组件涉及生物医学信号处理以分析复杂的液体混合物和微控制器)作为生物传感器,治疗递送元件和通信系统的界面,用于控制递送的治疗剂的量和 还向利害关系方提供有关治疗进展情况及其遵守情况的信息。 预期结合上述要素的协同效应将大大提高患者对规定治疗的依从性,医生提供的护理质量和及时性,同时降低向IDDC系统用户提供有效保健的成本,从而提高 管理保健组织和制药公司利用该系统。
-
公开(公告)号:US08214031B1
公开(公告)日:2012-07-03
申请号:US12130458
申请日:2008-05-30
申请人: Frederick A. Sexton
发明人: Frederick A. Sexton
IPC分类号: A61N1/30
CPC分类号: A61N1/327 , A61N1/0412
摘要: A transdermal device such as a patch can include a drug source, a porator, and an energy storage device on-board the patch. The porator operates free of any concurrent connection to any external source of power. A switch can be used to make the selective electrical connection between the porator and the energy storage device. The switch can be arranged to respond to a manual user action after the patch has been adhered to skin, including separation of the porator from a remainder of the patch. Optionally, a series of switches can make electrical connections between the porator and respective individual energy storage devices.
摘要翻译: 诸如补片的透皮装置可以包括药片,穿孔器和贴片上的储能装置。 搬运工无需任何外部任何电源的并发连接。 可以使用开关来进行导向器和储能装置之间的选择性电连接。 该开关可以布置成在贴片已经粘附到皮肤上之后响应于手动用户动作,包括将该穿孔器与该贴片的其余部分分开。 可选地,一系列开关可以在该穿孔器和相应的各个储能装置之间进行电连接。
-
公开(公告)号:US08047399B1
公开(公告)日:2011-11-01
申请号:US12167966
申请日:2008-07-03
申请人: Frederick A. Sexton
发明人: Frederick A. Sexton
IPC分类号: G07F11/00
CPC分类号: A61F15/001
摘要: A dispenser places transdermal devices and packaged transdermal devices in an electrically charged state. The dispenser is particularly suitable for transdermal devices that include electrically actuatable components, such as transdermal, drug-delivery patches that include microporator circuitry. A controller can be operatively coupled to a power circuit of the dispenser to control the times that transdermal devices can be charged, thereby providing a measure of control over use and misuse of the transdermal devices to be dispensed.
摘要翻译: 分配器将透皮装置和包装的透皮装置置于带电状态。 分配器特别适用于包括电可致动部件的经皮装置,例如包括微量放射器电路的经皮,药物递送贴片。 控制器可以可操作地耦合到分配器的电源电路以控制透皮装置可以充电的时间,从而提供对要分配的透皮装置的使用和误用的控制的量度。
-
公开(公告)号:US20090155409A1
公开(公告)日:2009-06-18
申请号:US12337022
申请日:2008-12-17
CPC分类号: A23L33/15 , A23G4/06 , A23L2/52 , A23L5/00 , A23L29/206 , A23L29/272 , A23L29/30 , A23L33/125 , A23L33/16 , A23L33/175 , A23L33/24 , A23L33/25 , A23L33/26 , A23L33/30 , A23L33/40 , A23P10/25 , A23P10/30 , A23V2002/00 , A23V2200/33 , A23V2250/51086 , A23V2250/51 , A23V2250/5026 , A23V2250/606 , A23V2250/608 , A23V2250/616 , A23V2250/612 , A23V2250/5114 , A23V2250/06 , A23V2250/50
摘要: Nutritional compositions delivered in vivo in a time controlled manner sustainable over long periods of time, provide enhancing athletic performance, increased hand/eye coordination and concentration on the task at hand.
摘要翻译: 营养组合物以时间控制的方式在长时间内持续运输,提供增强的运动表现,增加手/眼协调和集中在手头的任务。
-
公开(公告)号:US06780432B1
公开(公告)日:2004-08-24
申请号:US09702263
申请日:2000-10-31
IPC分类号: A61K922
CPC分类号: A61K9/4808 , A61K9/209 , A61K9/2813 , A61K31/44 , A61K31/155 , A61K2300/00
摘要: This invention relates to a combination drug product comprising pioglitazone hydrochloride and a biguamide, e.g. metformin. In particular, the product comprises a core of the biguamide, e.g. metformin, at least a portion thereof has a layer or coat thereon of pioglitazone.
摘要翻译: 本发明涉及包含盐酸吡格列酮和阿魏酰胺的组合药物。 二甲双胍 特别地,该产品包含一个核苷酸,例如, 二甲双胍,其至少一部分在其上具有吡格列酮的层或涂层。
-
公开(公告)号:US08095213B1
公开(公告)日:2012-01-10
申请号:US12130410
申请日:2008-05-30
申请人: Frederick A. Sexton
发明人: Frederick A. Sexton
IPC分类号: A61N1/30
CPC分类号: A61N1/0492 , A61N1/0424 , A61N1/327
摘要: A transdermal patch can include a drug source, a porator, and an energy storage device on-board the patch. Conductive contact terminals can extend from the energy storage device for connection to an external source of power. The porator operates free of any concurrent connection to any external source of power. A switch can be used to make the selective electrical connection between the porator and the energy storage device. The switch can be arranged to respond to a manual user action after the patch has been adhered to skin, including separation of the porator from a remainder of the patch. Optionally, a series of switches can make electrical connections between the porator and respective individual energy storage devices.In another aspect, a transdermal patch includes a mechanical bias that applies a displacement force to the porator to thereby better ensure good physical contact between the porator and the skin.
摘要翻译: 透皮贴剂可以包括药物源,穿孔器和贴片上的储能装置。 导电接触端子可以从能量存储装置延伸以连接到外部电源。 搬运工无需任何外部任何电源的并发连接。 可以使用开关来进行导向器和储能装置之间的选择性电连接。 该开关可以布置成在贴片已经粘附到皮肤上之后响应于手动用户动作,包括将该穿孔器与该贴片的其余部分分开。 可选地,一系列开关可以在该穿孔器和相应的各个储能装置之间进行电连接。 在另一方面,透皮贴剂包括对移位器施加移位力从而更好地确保穿孔器和皮肤之间良好的物理接触的机械偏压。
-
公开(公告)号:US06645468B2
公开(公告)日:2003-11-11
申请号:US10191123
申请日:2002-07-09
IPC分类号: A61K912
CPC分类号: A61K9/008 , A61K31/4439 , A61K38/22 , A61K38/26 , A61K38/28 , A61K45/06 , Y10S514/866 , A61K2300/00
摘要: This invention relates to medicinal aerosol and more formulation and more particularly, to a medicinal aerosol formulation containing rosiglitazone maleate and a fluid carrier.
-
公开(公告)号:US06548049B1
公开(公告)日:2003-04-15
申请号:US09702201
申请日:2000-10-31
IPC分类号: A61M1100
CPC分类号: A61K9/008 , A61K31/44 , A61K31/4439 , A61K31/64 , A61K38/26 , A61K38/28 , Y10S514/866 , A61K31/415 , A61K31/155 , A61K2300/00
摘要: This invention relates to a medicinal aerosol formulation and more particularly, to a medicinal aerosol formulation containing pioglitazone medicament and a fluid carrier.
摘要翻译: 本发明涉及药用气溶胶制剂,更具体地说,涉及含有吡格列酮药物和流体载体的医药气溶胶制剂。
-
公开(公告)号:US20120123335A1
公开(公告)日:2012-05-17
申请号:US13343633
申请日:2012-01-04
申请人: Frederick A. Sexton
发明人: Frederick A. Sexton
IPC分类号: A61M5/00
CPC分类号: A61N1/0492 , A61N1/0424 , A61N1/327
摘要: A transdermal patch can include a drug source, a porator, and an energy storage device on-board the patch. Conductive contact terminals can extend from the energy storage device for connection to an external source of power. The porator operates free of any concurrent connection to any external source of power. A switch can be used to make the selective electrical connection between the porator and the energy storage device. The switch can be arranged to respond to a manual user action after the patch has been adhered to skin, including separation of the porator from a remainder of the patch. Optionally, a series of switches can make electrical connections between the porator and respective individual energy storage devices.In another aspect, a transdermal patch includes a mechanical bias that applies a displacement force to the porator to thereby better ensure good physical contact between the porator and the skin.
摘要翻译: 透皮贴剂可以包括药物源,穿孔器和贴片上的储能装置。 导电接触端子可以从能量存储装置延伸以连接到外部电源。 搬运工无需任何外部任何电源的并发连接。 可以使用开关来进行导向器和储能装置之间的选择性电连接。 该开关可以布置成在贴片已经粘附到皮肤上之后响应于手动用户动作,包括将该穿孔器与该贴片的其余部分分开。 可选地,一系列开关可以在该穿孔器和相应的各个储能装置之间进行电连接。 在另一方面,透皮贴剂包括对移位器施加移位力从而更好地确保穿孔器和皮肤之间良好的物理接触的机械偏压。
-
-
-
-
-
-
-
-
-