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公开(公告)号：US5670172A
公开(公告)日：1997-09-23
申请号：US426065
申请日：1995-04-21
申请人： Ian Richard Buxton , Helen Critchley , Stewart Thomas Leslie , Derek Allan Prater , Ronald Brown Miller , Sandra Therese Antoinette Malkowska
发明人： Ian Richard Buxton , Helen Critchley , Stewart Thomas Leslie , Derek Allan Prater , Ronald Brown Miller , Sandra Therese Antoinette Malkowska
IPC分类号： A61K9/48 , A61K9/26 , A61K9/50 , A61K9/52 , A61K9/62 , A61K31/55 , A61K47/36 , A61P9/08 , A61P9/10 , A61P9/12 , A61K9/16 , A61K47/38
CPC分类号： A61K31/55 , A61K9/501 , A61K9/5015 , A61K9/5047 , A61K9/5073
摘要： A controlled release composition including spheroid cores of diltiazem or a pharmaceutically acceptable salt thereof and optionally a spheronizing agent, the cores being coated with a controlled release layer, and a method of manufacturing the same, is disclosed. The spheronizing agent when present is preferably microcrystalline cellulose. Ethylcellulose is a preferred release coating. The controlled release coating preferably contains a plasticizer, a surfactant and a tack-modifier.
摘要翻译： 公开了一种控释组合物，其包含地尔硫卓的球状核或其药学上可接受的盐和任选的滚圆剂，所述核被控释层涂覆，及其制造方法。 存在的滚圆剂优选为微晶纤维素。 乙基纤维素是优选的脱模涂层。 控释涂层优选含有增塑剂，表面活性剂和粘性改性剂。
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公开(公告)号：US07541350B2
公开(公告)日：2009-06-02
申请号：US10918779
申请日：2004-08-13
CPC分类号： A61K9/0078 , A61K9/0043 , A61K31/56 , A61K31/58 , A61K47/38
摘要： There is provided a pharmaceutical formulation comprising an aqueous suspension of particulate compound of formula (I) or a solvate thereof.
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公开(公告)号：US06858596B2
公开(公告)日：2005-02-22
申请号：US10067020
申请日：2002-02-04
IPC分类号： A61K9/10 , A61K9/00 , A61K31/56 , A61K31/568 , A61K31/57 , A61K31/58 , A61K47/02 , A61K47/18 , A61K47/34 , A61K47/36 , A61K47/38 , A61L9/04 , A61P5/44 , A61P11/02 , A61P29/00 , A61P37/08 , C07J3/00 , C07J17/00 , C07J53/00 , C07J71/00
CPC分类号： A61K9/0078 , A61K9/0043 , A61K31/56 , A61K31/58 , A61K47/38
摘要： There is provided a pharmaceutical formulation comprising an aqueous suspension of particulate compound of formula (I) or a solvate thereof.
摘要翻译： 提供了包含式（I）的颗粒化合物或其溶剂化物的水性悬浮液的药物制剂。
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公开(公告)号：US08637512B2
公开(公告)日：2014-01-28
申请号：US10726752
申请日：2003-12-02
CPC分类号： A61K9/2054 , A61K9/2031 , A61K9/2846 , A61K9/2866 , A61K31/53
摘要： A sustained release formulation of lamotrigine or a pharmaceutically acceptable derivative thereof and methods of treatment and uses thereof.
摘要翻译： 拉莫三嗪或其药学上可接受的衍生物的缓释制剂及其治疗方法及其用途。
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公开(公告)号：US5709851A
公开(公告)日：1998-01-20
申请号：US243534
申请日：1994-05-16
申请人： Ian Richard Buxton , Stewart Thomas Leslie , Sandra Therese Antoinette Malkowska , Allan John Miller , Ronald Brown Miller , Derek Allan Prater
发明人： Ian Richard Buxton , Stewart Thomas Leslie , Sandra Therese Antoinette Malkowska , Allan John Miller , Ronald Brown Miller , Derek Allan Prater
CPC分类号： A61K47/48176 , A61K33/18
摘要： A stable pharmaceutical composition with reduced irritancy is provided, the composition comprising an aqueous solution of elemental iodine and at least one organic substance which reacts with iodine, whereby iodine loss is controlled by providing a source of iodate ions in an amount sufficient to provide from 0.01% to 0.04% by weight iodate ions, preferably from 0.02% to 0.03% by weight iodate ions.
摘要翻译： 提供了具有降低的刺激性的稳定的药物组合物，该组合物包含元素碘水溶液和至少一种与碘反应的有机物质，由此通过提供足以提供0.01的量的碘酸根离子来控制碘损失 约0.04重量％的碘酸根离子，优选0.02重量％至0.03重量％的碘酸根离子。
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