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公开(公告)号：US07541350B2
公开(公告)日：2009-06-02
申请号：US10918779
申请日：2004-08-13
CPC分类号： A61K9/0078 , A61K9/0043 , A61K31/56 , A61K31/58 , A61K47/38
摘要： There is provided a pharmaceutical formulation comprising an aqueous suspension of particulate compound of formula (I) or a solvate thereof.
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公开(公告)号：US06858596B2
公开(公告)日：2005-02-22
申请号：US10067020
申请日：2002-02-04
IPC分类号： A61K9/10 , A61K9/00 , A61K31/56 , A61K31/568 , A61K31/57 , A61K31/58 , A61K47/02 , A61K47/18 , A61K47/34 , A61K47/36 , A61K47/38 , A61L9/04 , A61P5/44 , A61P11/02 , A61P29/00 , A61P37/08 , C07J3/00 , C07J17/00 , C07J53/00 , C07J71/00
CPC分类号： A61K9/0078 , A61K9/0043 , A61K31/56 , A61K31/58 , A61K47/38
摘要： There is provided a pharmaceutical formulation comprising an aqueous suspension of particulate compound of formula (I) or a solvate thereof.
摘要翻译： 提供了包含式（I）的颗粒化合物或其溶剂化物的水性悬浮液的药物制剂。
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公开(公告)号：US20120142651A1
公开(公告)日：2012-06-07
申请号：US13370493
申请日：2012-02-10
申请人： Keith Biggadike , Ian Buxton , Steven John Coote , Rosalyn Kay Nice , Kenton Lewis Reed , Amyn Sayani , Avinash Chander Sharma
发明人： Keith Biggadike , Ian Buxton , Steven John Coote , Rosalyn Kay Nice , Kenton Lewis Reed , Amyn Sayani , Avinash Chander Sharma
CPC分类号： A61K9/0078 , A61K9/0043 , A61K31/56 , A61K31/58 , A61K47/38
摘要： There is provided a method of treatment of allergic rhinitis which comprises administering to a patient a pharmaceutically acceptable amount of a pharmaceutical formulation comprising an aqueous suspension of particulate compound of formula (I) or a solvate thereof, wherein the administration is once-per-day and intranasal, and the total daily dose of the compound (I) is 50 to 100 μg.
摘要翻译： 提供了一种治疗过敏性鼻炎的方法，其包括给予患者药学上可接受量的药物制剂，其包含式（I）的颗粒化合物或其溶剂化物的水性悬浮液，其中所述给药是每天一次 和鼻内，化合物（I）的总日剂量为50〜100μg。
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公开(公告)号：US20100311706A1
公开(公告)日：2010-12-09
申请号：US12858940
申请日：2010-08-18
申请人： Keith Biggadike , Ian Buxton , Steven John Coote , Rosalyn Kay Nice , Kenton Lewis Reed , Amyn Sayani , Avinash Chander Sharma
发明人： Keith Biggadike , Ian Buxton , Steven John Coote , Rosalyn Kay Nice , Kenton Lewis Reed , Amyn Sayani , Avinash Chander Sharma
CPC分类号： A61K9/0078 , A61K9/0043 , A61K31/56 , A61K31/58 , A61K47/38
摘要： There is provided a method of treatment of allergic rhinitis which comprises administering to a patient a pharmaceutically acceptable amount of a pharmaceutical formulation comprising an aqueous suspension of particulate compound of formula (I) or a solvate thereof, wherein the administration is once-per-day and intranasal, and the total daily dose of the compound (I) is 50 to 100 μg.
摘要翻译： 提供了一种治疗过敏性鼻炎的方法，其包括给予患者药学上可接受量的药物制剂，其包含式（I）的颗粒化合物或其溶剂化物的水性悬浮液，其中所述给药是每天一次 和鼻内，化合物（I）的总日剂量为50〜100μg。
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5.发明授权Purine derivatives for use in the treatment of allergic, inflammatory and infectious diseases 有权嘌呤衍生物用于治疗过敏性，炎性和感染性疾病公开(公告)号：US08765772B2
公开(公告)日：2014-07-01
申请号：US13058470
申请日：2009-08-07
申请人： Keith Biggadike , Diane Mary Coe , Xiao Qing Lewell , Charlotte Jane Mitchell , Stephen Allan Smith , Naimisha Trivedi
发明人： Keith Biggadike , Diane Mary Coe , Xiao Qing Lewell , Charlotte Jane Mitchell , Stephen Allan Smith , Naimisha Trivedi
IPC分类号： A61K31/522 , C07D473/34
CPC分类号： A61K31/522 , A61K9/0043 , A61K31/55 , A61K45/06 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/00 , C07D473/16 , C07D473/18
摘要： The present invention relates to compounds of formula (I): wherein R1 is C1-6alkylamino, C1-6alkoxy, or C3-7cycloalkyloxy; m is an integer having a value of 3 to 6; n is an integer having a value of 0 to 4; and salts thereof are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment of various disorders, for example the treatment of allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, the treatment of infectious diseases and cancer, and may also be useful as vaccine adjuvants.
摘要翻译： 本发明涉及式（I）的化合物：其中R 1是C 1-6烷基氨基，C 1-6烷氧基或C 3-7环烷氧基; m为3〜6的整数， n为0〜4的整数， 其盐是人类干扰素的诱导剂。 诱导人类干扰素的化合物可用于治疗各种疾病，例如治疗过敏性疾病和其它炎性病症，例如过敏性鼻炎和哮喘，治疗感染性疾病和癌症，并且也可用作疫苗佐剂。
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6.发明申请公开(公告)号：US20140051720A1
公开(公告)日：2014-02-20
申请号：US14110437
申请日：2012-04-05
申请人： Keith Biggadike , Gianpaolo Bravi , Aurelie Cecile Champigny , Diane Mary Coe , Deborah Needham , Dainiel Terence Tape
发明人： Keith Biggadike , Gianpaolo Bravi , Aurelie Cecile Champigny , Diane Mary Coe , Deborah Needham , Dainiel Terence Tape
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： A compound of formula (I) wherein X represents a H atom, or a CH2OH group, Y represents a H atom, or a CH2OH group, but X and Y are not both CH2OH groups and Ar is selected from or a pharmaceutically acceptable salt thereof.
摘要翻译： 式（I）的化合物，其中X表示H原子，或CH 2 OH基，Y表示H原子或CH 2 OH基，但X和Y不同时为CH 2 OH基，Ar选自其药学上可接受的盐 。
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公开(公告)号：US07943651B2
公开(公告)日：2011-05-17
申请号：US11736606
申请日：2007-04-18
IPC分类号： C07D231/56 , A01N43/56
CPC分类号： C07D403/10 , C07D231/56
摘要： The present invention provides compounds of formula (I): pharmaceutical compositions comprising the compounds and the use of the compounds for the manufacture of a medicament, particularly for the treatment of inflammation and/or allergic conditions.
摘要翻译： 本发明提供式（I）化合物：包含该化合物的药物组合物和该化合物在制备药物中的用途，特别是用于治疗炎症和/或过敏性疾病。
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公开(公告)号：US20100016331A1
公开(公告)日：2010-01-21
申请号：US12444719
申请日：2007-10-10
IPC分类号： A61K31/497 , C07D231/56 , A61K31/415 , C07D403/08 , C07D401/08 , A61K31/445
CPC分类号： C07D231/56 , A61K45/06 , C07D401/10 , C07D403/10 , C07D405/12 , C07D409/12 , C07D413/12
摘要： The present invention provides compounds of formula (I): a process for their preparation, pharmaceutical compositions comprising the compounds and the preparation of said compositions, intermediates and use of the compounds for the manufacture of a medicament for therapeutic treatment, particularly for the treatment of inflammation, allergy and/or skin disease.
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公开(公告)号：US20090156567A1
公开(公告)日：2009-06-18
申请号：US12339607
申请日：2008-12-19
申请人： Keith Biggadike
发明人： Keith Biggadike
IPC分类号： A61K31/58
CPC分类号： A61K31/58 , A61K9/0043 , A61K31/56
摘要： According to one aspect of the invention, there is provided a compound of formula (I) and solvates thereof. There are also provided compositions containing the compound, processes for preparing it, and its use in therapy.
摘要翻译： 根据本发明的一个方面，提供式（I）的化合物及其溶剂合物。 还提供含有该化合物的组合物，其制备方法及其在治疗中的用途。
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公开(公告)号：US20060148771A1
公开(公告)日：2006-07-06
申请号：US10544869
申请日：2004-02-12
申请人： Keith Biggadike , Philip Box , Diane Coe , Duncan Holmes , Brian Looker , Panayiotis Procopiou
发明人： Keith Biggadike , Philip Box , Diane Coe , Duncan Holmes , Brian Looker , Panayiotis Procopiou
IPC分类号： A61K31/58 , A61K31/538 , A61K31/4704 , A61K31/428 , A61K31/549 , A61K31/405 , A61K31/35 , A61K31/325 , A61K31/225 , A61K31/138
CPC分类号： C07D213/65 , C07C217/28
摘要： A compound of formula (I) or a salt, solvate, or physiologically functional derivative thereof, wherein: m is an integer of from 2 to 8; n is an integer of from 2 to 5; with the proviso that m+n is 4 to 10; R4 and R5 are independently selected from hydrogen and C1-4alkyl with the proviso that the total number of carbon atoms in R4 and R5 is not more than 4; R6 and R7 are independently selected from hydrogen and C1-4alkyl with the proviso that the total number of carbon atoms in R6 and R7 is not more than 4, and Ar1 is a group selected from (a), (b), (c) and (d).
摘要翻译： 式（I）化合物或其盐，溶剂合物或生理功能衍生物，其中：m为2至8的整数; n为2〜5的整数， 条件是m + n为4至10; R 4和R 5独立地选自氢和C 1-4 - 烷基，条件是R 3中的碳原子总数 SUP> 4和R 5不超过4; R 6和R 7独立地选自氢和C 1-4 - 烷基，条件是R 1中的碳原子总数 SUP> 6和R 7不超过4，Ar 1是选自（a），（b），（c）和 （d）。
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