利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

4 条记录 (耗时 0.014 秒)

    Plexin D1 as a target for tumor diagnosis and therapy
    1.
    发明授权
    Plexin D1 as a target for tumor diagnosis and therapy 有权
    Plexin D1作为肿瘤诊断和治疗的靶标

    公开(公告)号：US09422358B2

    公开(公告)日：2016-08-23

    申请号：US13541296

    申请日：2012-07-03

    申请人： Wilhelmus Petrus Johannes Leenders ,  Ilse Roodink ,  Jozef Maria Hendrik Raats

    发明人： Wilhelmus Petrus Johannes Leenders ,  Ilse Roodink ,  Jozef Maria Hendrik Raats

    IPC分类号： A61K39/00 ,  C07K14/705 ,  A61K39/395 ,  C07K16/28

    CPC分类号： C07K16/28 ,  A61K9/0019 ,  A61K39/39558 ,  A61K47/6803 ,  A61K47/6817 ,  A61K47/6849 ,  A61K51/1018 ,  C07K14/705 ,  C07K2317/22 ,  C07K2317/569

    摘要： The present invention relates to plexin D1 for use as a targetable protein in the treatment or diagnosis of disorders that involve expression of plexin D1. Diagnosis is suitably effected by detecting the presence of plexin D1 in the body or a bodily tissue or fluid, whereas treatment is effected by targeting plexin D1 for delivery of therapeutics to the site where treatment is needed. The invention further relates to the use of molecules that bind plexin D1, a nucleic acid encoding plexine D1 or a ligand of plexin D1 for the preparation of a therapeutical composition for the treatment or diagnosis of disorders that involve expression of plexin D1. The disorders comprise disorders in which plexin D1 is expressed on tumor cells, tumor blood vessels or activated macrophages.

    摘要翻译： 本发明涉及在涉及plexin D1表达的疾病的治疗或诊断中用作可靶向蛋白质的丛状蛋白D1。 通过检测身体或身体组织或液体中plexin D1的存在适当地进行诊断，而通过靶向plexin D1来实现治疗，以将治疗剂递送至需要治疗的部位。 本发明进一步涉及与plexin D1结合的分子的使用，编码plexin D1或plexin D1的配体的核酸用于制备用于治疗或诊断涉及plexin D1表达的病症的治疗组合物。 这些疾病包括其中plexin D1在肿瘤细胞，肿瘤血管或活化的巨噬细胞上表达的疾病。

    ANTI-SPIKE GLYCOPROTEIN ANTIBODIES AND THE THERAPEUTIC USE THEREOF
    2.
    发明公开
    ANTI-SPIKE GLYCOPROTEIN ANTIBODIES AND THE THERAPEUTIC USE THEREOF 审中-公开

    公开(公告)号：US20230250158A1

    公开(公告)日：2023-08-10

    申请号：US18173772

    申请日：2023-02-23

    申请人： Ilse Roodink ,  Yasmina Noubia Abdiche ,  Jennifer L. Bath

    发明人： Ilse Roodink ,  Yasmina Noubia Abdiche ,  Jennifer L. Bath

    IPC分类号： C07K16/10 ,  A61P31/14

    CPC分类号： C07K16/10 ,  A61P31/14 ,  A61K2039/505

    摘要： The present application relates to neutralizing antibodies or antigen-binding fragments thereof against betacoronaviruses such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), to nucleic acid(s) encoding such neutralizing antibodies or antigen-binding fragments thereof, and to mixture and compositions comprising such antibodies, antigen-binding fragments or nucleic acids. Such neutralizing antibodies or antigen-binding fragments thereof are able to block betacoronavirus entry into cells and/or to induce complement-dependent cytotoxicity (CDC), antibody-dependent cellular cytotoxicity (ADCC) and/or antibody-dependent cellular phagocytosis (ADCP) against betacoronavirus-infected cells. Methods and uses of the antibodies, antigen-binding fragments thereof, nucleic acid(s) or compositions, including therapeutic, diagnostic, and preventative methods and uses for betacoronavirus infections and related diseases such as COVID-19, are also described.