-
公开(公告)号：US09422358B2
公开(公告)日：2016-08-23
申请号：US13541296
申请日：2012-07-03
IPC分类号： A61K39/00 , C07K14/705 , A61K39/395 , C07K16/28
CPC分类号： C07K16/28 , A61K9/0019 , A61K39/39558 , A61K47/6803 , A61K47/6817 , A61K47/6849 , A61K51/1018 , C07K14/705 , C07K2317/22 , C07K2317/569
摘要： The present invention relates to plexin D1 for use as a targetable protein in the treatment or diagnosis of disorders that involve expression of plexin D1. Diagnosis is suitably effected by detecting the presence of plexin D1 in the body or a bodily tissue or fluid, whereas treatment is effected by targeting plexin D1 for delivery of therapeutics to the site where treatment is needed. The invention further relates to the use of molecules that bind plexin D1, a nucleic acid encoding plexine D1 or a ligand of plexin D1 for the preparation of a therapeutical composition for the treatment or diagnosis of disorders that involve expression of plexin D1. The disorders comprise disorders in which plexin D1 is expressed on tumor cells, tumor blood vessels or activated macrophages.
摘要翻译： 本发明涉及在涉及plexin D1表达的疾病的治疗或诊断中用作可靶向蛋白质的丛状蛋白D1。 通过检测身体或身体组织或液体中plexin D1的存在适当地进行诊断，而通过靶向plexin D1来实现治疗，以将治疗剂递送至需要治疗的部位。 本发明进一步涉及与plexin D1结合的分子的使用，编码plexin D1或plexin D1的配体的核酸用于制备用于治疗或诊断涉及plexin D1表达的病症的治疗组合物。 这些疾病包括其中plexin D1在肿瘤细胞，肿瘤血管或活化的巨噬细胞上表达的疾病。
-
公开(公告)号：US20120321554A1
公开(公告)日：2012-12-20
申请号：US13541296
申请日：2012-07-03
IPC分类号： A61K39/395 , C07K16/28 , C07K2/00 , C07H21/04 , C07H21/02 , A61K38/02 , A61K31/711 , A61K31/7105 , A61K31/713 , A61K31/7125 , G01N33/53 , A61K51/00 , A61K33/24 , A61K38/14 , A61K9/127 , A61P35/00 , A61P29/00 , A61P25/00 , A61P37/08 , C07K14/705
CPC分类号： C07K16/28 , A61K9/0019 , A61K39/39558 , A61K47/6803 , A61K47/6817 , A61K47/6849 , A61K51/1018 , C07K14/705 , C07K2317/22 , C07K2317/569
摘要： The present invention relates to plexin D1 for use as a targetable protein in the treatment or diagnosis of disorders that involve expression of plexin D1. Diagnosis is suitably effected by detecting the presence of plexin D1 in the body or a bodily tissue or fluid, whereas treatment is effected by targeting plexin D1 for delivery of therapeutics to the site where treatment is needed. The invention further relates to the use of molecules that bind plexin D1, a nucleic acid encoding plexine D1 or a ligand of plexin D1 for the preparation of a therapeutical composition for the treatment or diagnosis of disorders that involve expression of plexin D1. The disorders comprise disorders in which plexin D1 is expressed on tumor cells, tumor blood vessels or activated macrophages.
摘要翻译： 本发明涉及在涉及plexin D1表达的疾病的治疗或诊断中用作可靶向蛋白质的丛状蛋白D1。 通过检测身体或身体组织或液体中plexin D1的存在适当地进行诊断，而通过靶向plexin D1来实现治疗，以将治疗剂递送至需要治疗的部位。 本发明进一步涉及与plexin D1结合的分子的使用，编码plexin D1或plexin D1的配体的核酸用于制备用于治疗或诊断涉及plexin D1表达的病症的治疗组合物。 障碍包括其中plexin D1在肿瘤细胞，肿瘤血管或活化的巨噬细胞上表达的疾病。
-
公开(公告)号：US20100119445A1
公开(公告)日：2010-05-13
申请号：US11996166
申请日：2006-07-20
IPC分类号： A61K51/00 , A61K9/127 , A61K39/395 , C12Q1/68 , G01N33/53 , A61K38/00 , A61K38/16 , A61K31/7088 , A01N57/00 , C07K14/00 , C07K16/00
CPC分类号： C07K16/28 , A61K9/0019 , A61K39/39558 , A61K47/6803 , A61K47/6817 , A61K47/6849 , A61K51/1018 , C07K14/705 , C07K2317/22 , C07K2317/569
摘要： The present invention relates to plexin D1 for use as a targetable protein in the treatment or diagnosis of disorders that involve expression of plexin D1. Diagnosis is suitably effected by detecting the presence of plexin D1 in the body or a bodily tissue or fluid, whereas treatment is effected by targeting plexin D1 for delivery of therapeutics to the site where treatment is needed. The invention further relates to the use of molecules that bind plexin D1, a nucleic acid encoding plexine D1 or a ligand of plexin D1 for the preparation of a therapeutical composition for the treatment or diagnosis of disorders that involve expression of plexin D1. The disorders comprise disorders in which plexin D1 is expressed on tumor cells, tumor blood vessels or activated macrophages.
摘要翻译： 本发明涉及在涉及plexin D1表达的疾病的治疗或诊断中用作可靶向蛋白质的丛状蛋白D1。 通过检测身体或身体组织或液体中plexin D1的存在适当地进行诊断，而通过靶向plexin D1来实现治疗，以将治疗剂递送至需要治疗的部位。 本发明进一步涉及与plexin D1结合的分子的使用，编码plexin D1或plexin D1的配体的核酸用于制备用于治疗或诊断涉及plexin D1表达的病症的治疗组合物。 障碍包括其中plexin D1在肿瘤细胞，肿瘤血管或活化的巨噬细胞上表达的疾病。
-
公开(公告)号：US09718877B2
公开(公告)日：2017-08-01
申请号：US12737075
申请日：2009-06-04
CPC分类号： C07K16/40 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K14/4713 , C07K16/18 , C07K16/44 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/622 , C07K2317/92
摘要： This invention is in the field of treating or preventing inflammation in humans and animals and relates to pharmaceutical compositions and methods for treating or preventing various inflammatory conditions. In particular, the invention relates to compositions and methods for treating or preventing inflammatory conditions such as citrulline-related inflammatory diseases. The invention provides specific binding molecules directed against citrulline-containing epitopes for use in the therapy and prevention of inflammatory conditions.
-
公开(公告)号：US20110243945A1
公开(公告)日：2011-10-06
申请号：US12737075
申请日：2009-06-04
IPC分类号： A61K39/395 , A61K38/10 , C07K14/47 , C07H21/00 , A61K39/00 , A61P29/00 , A61P25/28 , A61P17/06 , A61P25/16 , A61P25/00 , A61P19/08 , A61P19/02
CPC分类号： C07K16/40 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K14/4713 , C07K16/18 , C07K16/44 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/622 , C07K2317/92
摘要： This invention is in the field of treating or preventing inflammation in humans and animals and relates to pharmaceutical compositions and methods for treating or preventing various inflammatory conditions. In particular, the invention relates to compositions and methods for treating or preventing inflammatory conditions such as citrulline related inflammatory diseases. The invention provides specific binding molecules directed against citrulline-containing epitopes for use in the therapy and prevention of inflammatory conditions.
摘要翻译： 本发明涉及治疗或预防人和动物炎症的领域，涉及用于治疗或预防各种炎性病症的药物组合物和方法。 特别地，本发明涉及用于治疗或预防炎性病症如瓜氨酸相关的炎性疾病的组合物和方法。 本发明提供了针对含有瓜氨酸的表位的特异性结合分子，用于治疗和预防炎性病症。
-
公开(公告)号：US20110142868A1
公开(公告)日：2011-06-16
申请号：US12965536
申请日：2010-12-10
申请人： Richard Hendrik Blaauw , Gerardus Jozef Maria Pruijn , Jozef Maria Hendrik Raats , Floris Petrus Johannes Theodorus Rutjes , Jan Wouter Drijfhout
发明人： Richard Hendrik Blaauw , Gerardus Jozef Maria Pruijn , Jozef Maria Hendrik Raats , Floris Petrus Johannes Theodorus Rutjes , Jan Wouter Drijfhout
CPC分类号： C07K7/06 , A61K38/00 , C07K7/08 , C07K14/47 , C07K14/4713
摘要： The invention relates to PAD inhibitors that are suitable to be used as a medicament against an autoimmune disease such as RA.
摘要翻译： 本发明涉及适合用作抗自身免疫疾病如RA的药物的PAD抑制剂。
-
7.发明授权Peptides immunoreactive with autoantibodies from patients suffering from rheumatoid arthritis 失效与患有类风湿性关节炎患者的自身抗体免疫反应的肽公开(公告)号：US08772448B2
公开(公告)日：2014-07-08
申请号：US11834557
申请日：2007-08-06
申请人： Waltherus Jacobus Wilhelmus Van Venrooij , Gerardus Antonius Schellekens , Jozef Maria Hendrik Raats , Rene Michael Antonius Hoet
发明人： Waltherus Jacobus Wilhelmus Van Venrooij , Gerardus Antonius Schellekens , Jozef Maria Hendrik Raats , Rene Michael Antonius Hoet
CPC分类号： G01N33/6893 , C07K14/47 , C07K14/4713 , C07K16/18 , G01N33/564 , G01N2333/46 , G01N2800/10 , G01N2800/102 , G01N2800/24
摘要： The invention relates to a peptide derived from an antigen recognized by autoantibodies, which peptide is reactive with autoimmune antibodies from a patient suffering from rheumatoid arthritis. The peptide according to the invention possesses a modified arginine residue. The invention also relates to antibodies against the peptide and a method of detecting autoimmune antibodies.
摘要翻译： 本发明涉及由自身抗体识别的抗原衍生的肽，该肽与患有类风湿性关节炎的患者的自身免疫抗体反应。 根据本发明的肽具有修饰的精氨酸残基。 本发明还涉及针对肽的抗体和检测自身免疫抗体的方法。
-
公开(公告)号：US20120321631A1
公开(公告)日：2012-12-20
申请号：US13514923
申请日：2010-12-10
IPC分类号： A61K39/395 , C12N15/13 , A61P29/00 , C07K16/18
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/44 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/622
摘要： This invention is in the field of treating or preventing inflammation in humans and animals and relates to pharmaceutical compositions and methods for treating or preventing various inflammatory conditions. In particular, the invention relates to compositions and methods for treating or preventing inflammatory conditions such as citrulline related inflammatory diseases. The invention provides specific binding molecules directed against citrulline-containing epitopes for use in the therapy and prevention of inflammatory conditions.
摘要翻译： 本发明涉及治疗或预防人和动物炎症的领域，涉及用于治疗或预防各种炎性病症的药物组合物和方法。 特别地，本发明涉及用于治疗或预防炎性病症如瓜氨酸相关的炎性疾病的组合物和方法。 本发明提供了针对含有瓜氨酸的表位的特异性结合分子，用于治疗和预防炎性病症。
-
公开(公告)号：US09109019B2
公开(公告)日：2015-08-18
申请号：US13514923
申请日：2010-12-10
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/44 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/622
摘要： This invention is in the field of treating or preventing inflammation in humans and animals and relates to pharmaceutical compositions and methods for treating or preventing various inflammatory conditions. In particular, the invention relates to compositions and methods for treating or preventing inflammatory conditions such as citrulline-related inflammatory diseases. The invention provides specific binding molecules directed against citrulline-containing epitopes for use in the therapy and prevention of inflammatory conditions.
摘要翻译： 本发明涉及治疗或预防人和动物炎症的领域，涉及用于治疗或预防各种炎性病症的药物组合物和方法。 特别地，本发明涉及用于治疗或预防炎性病症如瓜氨酸相关炎性疾病的组合物和方法。 本发明提供了针对含有瓜氨酸的表位的特异性结合分子，用于治疗和预防炎性病症。
-
公开(公告)号：US08404647B2
公开(公告)日：2013-03-26
申请号：US12965536
申请日：2010-12-10
申请人： Richard Hendrik Blaauw , Gerardus Jozef Maria Pruijn , Jozef Maria Hendrik Raats , Floris Petrus Johannes Theodorus Rutjes , Jan Wouter Drijfhout
发明人： Richard Hendrik Blaauw , Gerardus Jozef Maria Pruijn , Jozef Maria Hendrik Raats , Floris Petrus Johannes Theodorus Rutjes , Jan Wouter Drijfhout
CPC分类号： C07K7/06 , A61K38/00 , C07K7/08 , C07K14/47 , C07K14/4713
摘要： The invention relates to PAD inhibitors that are suitable to be used as a medicament against an autoimmune disease such as RA.
摘要翻译： 本发明涉及适合用作抗自身免疫疾病如RA的药物的PAD抑制剂。
-
-
-
-
-
-
-
-
-
搜索结果
12 条记录 (耗时 0.029 秒)
